CtsL1 Cathepsin L1 [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: CtsL1provided by FlyBase
Official Full Name: Cathepsin L1provided by FlyBase
Primary source: FLYBASE:FBgn0013770
Locus tag: Dmel_CG6692
See related: AllianceGenome:FB:FBgn0013770
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: Cath L; CathL; CatL; CATL_DROME; CG6692; CL; cp1; Cp1; CP1; CT20780; Cts1; Cts2; CtsL; CTSL; CysP-1; Dcp-1; DCP-1; Dcp1; DCP1; Dmel\CG6692; fs(2)50Ca
Summary: Enables cysteine-type endopeptidase activity. Involved in proteolysis. Located in fusome and lysosome. Is expressed in several structures, including central nervous system; circulatory system; dorsal closure embryo; embryonic/larval digestive system; and gonad. Human ortholog(s) of this gene implicated in hypertrophic cardiomyopathy. Orthologous to human CTSL (cathepsin L) and CTSV (cathepsin V). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: all
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Genomic context

Location:: 50C18-50C20; 2-68 cM

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2R	NT_033778.4 (13960675..13967981)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2R	NT_033778.3 (9848180..9855486)

Chromosome 2R - NT_033778.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Cp1 and cortex glia have roles in in alcohol-related behaviors in Drosophila
Title: Alcohol sedation in adult Drosophila is regulated by Cysteine proteinase-1 in cortex glia.
Data show that cysteine proteinase 1 (CP1) is expressed in air sac primordium (ASP) and knockdown of CP1 results in suppression of migratory and invasive behavior observed during ASP development.
Title: A Cathepsin-L is required for invasive behavior during Air Sac Primordium development in Drosophila melanogaster.
Data show the models of the tertiary structures of cathepsin L constructed by using homology modeling methods.
Title: Structural and functional conservation profiles of novel cathepsin L-like proteins identified in the Drosophila melanogaster genome.
Premature activation of the effector caspase, dcp1, resulted in a disappearance of filamentous actin, rather than the formation of actin bundles, suggesting that dcp-1 activity must be restrained in late oogenesis.
Title: Stage-specific regulation of caspase activity in drosophila oogenesis.
Drosophila decapping protein 1, dDcp1, is a posterior group gene required for the transport of osk mRNA.
Title: Drosophila decapping protein 1, dDcp1, is a component of the oskar mRNP complex and directs its posterior localization in the oocyte.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables cysteine-type endopeptidase activator activity involved in apoptotic process	IBA Inferred from Biological aspect of Ancestor more info
enables cysteine-type endopeptidase activity	IBA Inferred from Biological aspect of Ancestor more info
enables cysteine-type endopeptidase activity	IDA Inferred from Direct Assay more info	PubMed
enables cysteine-type peptidase activity	IDA Inferred from Direct Assay more info	PubMed
enables cysteine-type peptidase activity	IEA Inferred from Electronic Annotation more info
enables peptidase activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in immune response	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of apoptotic signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of peptidase activity	IBA Inferred from Biological aspect of Ancestor more info
involved_in proteolysis	IDA Inferred from Direct Assay more info	PubMed
involved_in proteolysis	IEA Inferred from Electronic Annotation more info
involved_in proteolysis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in proteolysis involved in protein catabolic process	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in autolysosome	IMP Inferred from Mutant Phenotype more info	PubMed
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in fusome	IDA Inferred from Direct Assay more info	PubMed
located_in late endosome	IDA Inferred from Direct Assay more info	PubMed
is_active_in lysosome	IBA Inferred from Biological aspect of Ancestor more info
located_in lysosome	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: cathepsin L1

Names: CG6692-PA; CG6692-PC; CG6692-PD; CG6692-PE; Cathepsin-L; Cathepsin-L-like protease; CathepsinL; CtsL1-PA; CtsL1-PC; CtsL1-PD; CtsL1-PE; L-like cysteine protease; cathepsin L; cysteine proteinase 1; cysteine proteinase-1; drosophila cysteine proteinase-1

NP_001188921.1

EC 3.4.-.-

EC 3.4.22.-

NP_523735.2

EC 3.4.-.-

EC 3.4.22.-

NP_725347.1

EC 3.4.-.-

EC 3.4.22.-

NP_725348.2

EC 3.4.-.-

EC 3.4.22.-

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033778.4 Reference assembly

Range

13960675..13967981

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_166026.3 → NP_725347.1 cathepsin L1, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_725347.1

Status: REVIEWED

UniProtKB/TrEMBL

C6SV44

Related

FBpp0086718

Conserved Domains (2) summary

smart00848
Location:29 → 88

Inhibitor_I29; Cathepsin propeptide inhibitor domain (I29)

pfam00112
Location:124 → 340

Peptidase_C1; Papain family cysteine protease
NM_079011.3 → NP_523735.2 cathepsin L1, isoform C [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_523735.2

Status: REVIEWED

UniProtKB/Swiss-Prot

O97431, Q5U121, Q95029

UniProtKB/TrEMBL

C6SV44

Related

FBpp0086719

Conserved Domains (2) summary

smart00848
Location:59 → 118

Inhibitor_I29; Cathepsin propeptide inhibitor domain (I29)

pfam00112
Location:154 → 370

Peptidase_C1; Papain family cysteine protease
NM_166027.3 → NP_725348.2 cathepsin L1, isoform E [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_725348.2

Status: REVIEWED

UniProtKB/TrEMBL

C6SV44

Conserved Domains (2) summary

smart00848
Location:32 → 85

Inhibitor_I29; Cathepsin propeptide inhibitor domain (I29)

pfam00112
Location:121 → 337

Peptidase_C1; Papain family cysteine protease
NM_001201992.1 → NP_001188921.1 cathepsin L1, isoform D [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001188921.1

Status: REVIEWED

UniProtKB/TrEMBL

A0A0B4JD48

Conserved Domains (1) summary

pfam00112
Location:32 → 248

Peptidase_C1; Papain family cysteine protease