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    Pip4k2c phosphatidylinositol-5-phosphate 4-kinase, type II, gamma [ Mus musculus (house mouse) ]

    Gene ID: 117150, updated on 14-Nov-2024

    Summary

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    Official Symbol
    Pip4k2cprovided by MGI
    Official Full Name
    phosphatidylinositol-5-phosphate 4-kinase, type II, gammaprovided by MGI
    Primary source
    MGI:MGI:2152214
    See related
    Ensembl:ENSMUSG00000025417 AllianceGenome:MGI:2152214
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Pip5k2c
    Summary
    Predicted to enable 1-phosphatidylinositol-4-phosphate 5-kinase activity; 1-phosphatidylinositol-5-phosphate 4-kinase activity; and identical protein binding activity. Predicted to be involved in 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate biosynthetic process; negative regulation of insulin receptor signaling pathway; and positive regulation of autophagosome assembly. Predicted to be located in autophagosome; cytosol; and nucleoplasm. Predicted to be active in plasma membrane. Is expressed in several structures, including alimentary system; brain; eye; genitourinary system; and immune system. Orthologous to human PIP4K2C (phosphatidylinositol-5-phosphate 4-kinase type 2 gamma). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in kidney adult (RPKM 43.6), genital fat pad adult (RPKM 30.5) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Pip4k2c in Genome Data Viewer
    Location:
    10 D3; 10 74.5 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (127032936..127047508, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (127197067..127211628, complement)

    Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene Rho guanine nucleotide exchange factor 25 Neighboring gene RIKEN cDNA F420014N23 gene Neighboring gene deltex 3, E3 ubiquitin ligase Neighboring gene STARR-seq mESC enhancer starr_28215 Neighboring gene kinesin family member 5A Neighboring gene STARR-positive B cell enhancer ABC_E9810 Neighboring gene predicted gene, 40800 Neighboring gene dynactin 2 Neighboring gene methyl-CpG binding domain protein 6

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Therapeutic Delivery of Pip4k2c-Modified mRNA Attenuates Cardiac Hypertrophy and Fibrosis in the Failing Heart. Magadum A, et al. Adv Sci (Weinh), 2021 May. PMID 34026458, Free PMC Article
    2. Deletion of the gene Pip4k2c, a novel phosphatidylinositol kinase, results in hyperactivation of the immune system. Shim H, et al. Proc Natl Acad Sci U S A, 2016 Jul 5. PMID 27313209, Free PMC Article
    3. Localization of phosphatidylinositol phosphate kinase IIgamma in kidney to a membrane trafficking compartment within specialized cells of the nephron. Clarke JH, et al. Am J Physiol Renal Physiol, 2008 Nov. PMID 18753295, Free PMC Article
    4. Distribution and neuronal expression of phosphatidylinositol phosphate kinase IIgamma in the mouse brain. Clarke JH, et al. J Comp Neurol, 2009 Nov 20. PMID 19757494, Free PMC Article
    5. Altered phenotypes due to genetic interaction between the mouse phosphoinositide biosynthesis genes Fig4 and Pip4k2c. Cao X, et al. G3 (Bethesda), 2023 Aug 9. PMID 36691351, Free PMC Article

    See all (33) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Altered phenotypes due to genetic interaction between the mouse phosphoinositide biosynthesis genes Fig4 and Pip4k2c.
      Title: Altered phenotypes due to genetic interaction between the mouse phosphoinositide biosynthesis genes Fig4 and Pip4k2c.
    2. Therapeutic Delivery of Pip4k2c-Modified mRNA Attenuates Cardiac Hypertrophy and Fibrosis in the Failing Heart.
      Title: Therapeutic Delivery of Pip4k2c-Modified mRNA Attenuates Cardiac Hypertrophy and Fibrosis in the Failing Heart.
    3. PI5P4Kgamma plays a role in the regulation of the immune system via mTORC1 signaling.
      Title: Deletion of the gene Pip4k2c, a novel phosphatidylinositol kinase, results in hyperactivation of the immune system.
    4. our data suggest that PIP4Kgamma may have a role in neuron function, specifically in the regulation of vesicular transport, in specific regions of the developed brain
      Title: Distribution and neuronal expression of phosphatidylinositol phosphate kinase IIgamma in the mouse brain.
    5. PIP4Kgamma may have a function in the regulation of vesicular transport in specialized kidney epithelial cells.
      Title: Localization of phosphatidylinositol phosphate kinase IIgamma in kidney to a membrane trafficking compartment within specialized cells of the nephron.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (4) 
    • Targeted (2) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables 1-phosphatidylinositol-4-phosphate 5-kinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables 1-phosphatidylinositol-4-phosphate 5-kinase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables 1-phosphatidylinositol-5-phosphate 4-kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables 1-phosphatidylinositol-5-phosphate 4-kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables identical protein binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate biosynthetic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in negative regulation of insulin receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of insulin receptor signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in phosphatidylinositol phosphate biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of autophagosome assembly IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of autophagosome assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of autophagy ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in autophagosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in autophagosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in intracellular organelle ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    phosphatidylinositol 5-phosphate 4-kinase type-2 gamma
    Names
    PI(5)P 4-kinase type II gamma
    PIP4KII-gamma
    phosphatidylinositol-4-phosphate 5-kinase, type II, gamma
    NP_001346209.1
    NP_473438.1
    XP_006513184.1
    XP_011241590.1
    XP_011241591.1
    XP_036011413.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001359280.1 → NP_001346209.1  phosphatidylinositol 5-phosphate 4-kinase type-2 gamma

      Status: VALIDATED

      Source sequence(s)
      AB054591, AC144852, BB856667, BP766151
      Consensus CDS
      CCDS24232.1
      UniProtKB/Swiss-Prot
      Q3UFU5, Q91XU3, Q99K02
      Conserved Domains (1) summary
      cd17311
      Location:46 → 418
      PIPKc_PIP5K2C; Phosphatidylinositol phosphate kinase (PIPK) catalytic domain found in Phosphatidylinositol 5-phosphate 4-kinase type-2 gamma (PIP5K2C) and similar proteins

    2. NM_054097.3 → NP_473438.1  phosphatidylinositol 5-phosphate 4-kinase type-2 gamma

      See identical proteins and their annotated locations for NP_473438.1

      Status: VALIDATED

      Source sequence(s)
      AB054591, AC144852, BB856667
      Consensus CDS
      CCDS24232.1
      UniProtKB/Swiss-Prot
      Q3UFU5, Q91XU3, Q99K02
      Related
      ENSMUSP00000013970.8, ENSMUST00000013970.9
      Conserved Domains (1) summary
      cd17311
      Location:46 → 418
      PIPKc_PIP5K2C; Phosphatidylinositol phosphate kinase (PIPK) catalytic domain found in Phosphatidylinositol 5-phosphate 4-kinase type-2 gamma (PIP5K2C) and similar proteins

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000076.7 Reference GRCm39 C57BL/6J

      Range
      127032936..127047508 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011243289.4 → XP_011241591.1  phosphatidylinositol 5-phosphate 4-kinase type-2 gamma isoform X3

      Conserved Domains (1) summary
      cl28923
      Location:46 → 291
      PIPKc; Phosphatidylinositol phosphate kinase (PIPK) catalytic domain family

    2. XM_011243288.4 → XP_011241590.1  phosphatidylinositol 5-phosphate 4-kinase type-2 gamma isoform X1

      Conserved Domains (1) summary
      cl28923
      Location:117 → 349
      PIPKc; Phosphatidylinositol phosphate kinase (PIPK) catalytic domain family

    3. XM_006513121.5 → XP_006513184.1  phosphatidylinositol 5-phosphate 4-kinase type-2 gamma isoform X2

      See identical proteins and their annotated locations for XP_006513184.1

      Conserved Domains (1) summary
      cl28923
      Location:117 → 476
      PIPKc; Phosphatidylinositol phosphate kinase (PIPK) catalytic domain family

    4. XM_036155520.1 → XP_036011413.1  phosphatidylinositol 5-phosphate 4-kinase type-2 gamma isoform X2

      Conserved Domains (1) summary
      cl28923
      Location:117 → 476
      PIPKc; Phosphatidylinositol phosphate kinase (PIPK) catalytic domain family

    RNA

    1. XR_871695.3 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q91XU3.1 GenPept UniProtKB/Swiss-Prot:Q91XU3

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