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    Msmb beta-microseminoprotein [ Mus musculus (house mouse) ]

    Gene ID: 17695, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Msmbprovided by MGI
    Official Full Name
    beta-microseminoproteinprovided by MGI
    Primary source
    MGI:MGI:97166
    See related
    Ensembl:ENSMUSG00000021907 AllianceGenome:MGI:97166
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    PIP; PSP94; beta-MSP
    Summary
    Predicted to be located in extracellular region. Is expressed in male reproductive gland or organ. Used to study prostate cancer. Orthologous to human MSMB (microseminoprotein beta). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Low expression observed in reference dataset See more
    Orthologs
    human all
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    Genomic context

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    See Msmb in Genome Data Viewer
    Location:
    14 B; 14 19.4 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (31863980..31880284)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (32142023..32158327)

    Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_36333 Neighboring gene diphthamine biosynthesis 3 Neighboring gene oxidoreductase NAD-binding domain containing 1 Neighboring gene STARR-seq mESC enhancer starr_36334 Neighboring gene STARR-seq mESC enhancer starr_36335 Neighboring gene predicted gene, 57612 Neighboring gene STARR-seq mESC enhancer starr_36337 Neighboring gene STARR-seq mESC enhancer starr_36339 Neighboring gene predicted gene, 41127 Neighboring gene eukaryotic translation initiation factor 5 pseudogene Neighboring gene nuclear receptor coactivator 4 Neighboring gene translocase of inner mitochondrial membrane 23 Neighboring gene predicted gene, 23946

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. cDNA, genomic cloning, and gene expression analysis of mouse PSP94 (prostate secretory protein of 94 amino acids). Xuan JW, et al. DNA Cell Biol, 1999 Jan. PMID 10025505
    2. High milk consumption does not affect prostate tumor progression in two mouse models of benign and neoplastic lesions. Bernichtein S, et al. PLoS One, 2015. PMID 25938513, Free PMC Article
    3. Mouse PSP94 expression is prostate tissue-specific as demonstrated by a comparison of multiple antibodies against recombinant proteins. Thota A, et al. J Cell Biochem, 2003 Apr 1. PMID 12616537
    4. Disulfide pairings and secondary structure of porcine beta-microseminoprotein. Wang I, et al. FEBS Lett, 2003 Apr 24. PMID 12706823
    5. Knockin of SV40 Tag oncogene in a mouse adenocarcinoma of the prostate model demonstrates advantageous features over the transgenic model. Duan W, et al. Oncogene, 2005 Feb 24. PMID 15674347

    See all (19) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Establishment and characterization of PSP94 antibodies contribute to the potential for PSP94 as a new vector gene for prostate cancer gene therapy
      Title: Mouse PSP94 expression is prostate tissue-specific as demonstrated by a comparison of multiple antibodies against recombinant proteins.
    2. knock-in mutation provides model for prostatic neoplasm
      Title: A novel knock-in prostate cancer model demonstrates biology similar to that of human prostate cancer and suitable for preclinical studies.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 
    • Gene trapped (2) 
    • Targeted (3)  1 citation

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    beta-microseminoprotein
    Names
    PSP-94
    beta-inhibin
    prostate secreted seminal plasma protein
    prostate secretory protein of 94 amino acids
    prostatic inhibin protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_020597.3 → NP_065622.1  beta-microseminoprotein precursor

      See identical proteins and their annotated locations for NP_065622.1

      Status: VALIDATED

      Source sequence(s)
      AC154532
      Consensus CDS
      CCDS36862.1
      UniProtKB/Swiss-Prot
      O08540
      Related
      ENSMUSP00000022464.7, ENSMUST00000022464.14
      Conserved Domains (1) summary
      pfam05825
      Location:21 → 113
      PSP94; Beta-microseminoprotein (PSP-94)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000080.7 Reference GRCm39 C57BL/6J

      Range
      31863980..31880284
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017315907.2 → XP_017171396.1  beta-microseminoprotein isoform X1

      Conserved Domains (1) summary
      pfam05825
      Location:96 → 188
      PSP94; Beta-microseminoprotein (PSP-94)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O08540.1 GenPept UniProtKB/Swiss-Prot:O08540

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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