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    Stk31 serine threonine kinase 31 [ Mus musculus (house mouse) ]

    Gene ID: 77485, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Stk31provided by MGI
    Official Full Name
    serine threonine kinase 31provided by MGI
    Primary source
    MGI:MGI:1924735
    See related
    Ensembl:ENSMUSG00000023403 AllianceGenome:MGI:1924735
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    C330007K24Rik
    Summary
    Enables protein kinase activity. Acts upstream of or within protein phosphorylation. Located in acrosomal vesicle. Is expressed in oocyte. Orthologous to human STK31 (serine/threonine kinase 31). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in testis adult (RPKM 3.3) and placenta adult (RPKM 1.7) See more
    Orthologs
    human all
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    Genomic context

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    See Stk31 in Genome Data Viewer
    Location:
    6 B2.3; 6 23.87 cM
    Exon count:
    25
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (49372441..49446440)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (49395506..49469506)

    Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E1321 Neighboring gene coiled-coil domain containing 126 Neighboring gene STARR-seq mESC enhancer starr_15828 Neighboring gene STARR-positive B cell enhancer ABC_E3654 Neighboring gene family with sequence similarity 221, member A Neighboring gene STARR-seq mESC enhancer starr_15829 Neighboring gene STARR-seq mESC enhancer starr_15830 Neighboring gene nucleophosmin 1 pseudogene Neighboring gene STARR-seq mESC enhancer starr_15831 Neighboring gene STARR-seq mESC enhancer starr_15832 Neighboring gene STARR-seq mESC enhancer starr_15833 Neighboring gene 40S ribosomal protein S6 pseudogene Neighboring gene ribosomal protein L19, pseudogene 8

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. STK31/TDRD8, a germ cell-specific factor, is dispensable for reproduction in mice. Zhou J, et al. PLoS One, 2014. PMID 24586802, Free PMC Article
    2. Stk31 is dispensable for embryonic development and spermatogenesis in mice. Bao J, et al. Mol Reprod Dev, 2013 Oct. PMID 23929668, Free PMC Article
    3. STK31(TDRD8) is dynamically regulated throughout mouse spermatogenesis and interacts with MIWI protein. Bao J, et al. Histochem Cell Biol, 2012 Mar. PMID 22205278
    4. Accelerated reproductive aging in females lacking a novel centromere protein SYCP2L. Zhou J, et al. Hum Mol Genet, 2015 Nov 15. PMID 26362258, Free PMC Article
    5. Transgenerational epigenetic effects imposed by neonicotinoid thiacloprid exposure. Dali O, et al. Life Sci Alliance, 2024 Feb. PMID 37973188, Free PMC Article

    See all (22) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The function of STK31 may be redundant with other Tdrd proteins in germ cell development.
      Title: STK31/TDRD8, a germ cell-specific factor, is dispensable for reproduction in mice.
    2. Stk31 is dispensable for both embryonic development and spermatogenesis in mice.
      Title: Stk31 is dispensable for embryonic development and spermatogenesis in mice.
    3. STK31 is expressed in embryonic gonocytes of both sexes and postnatal spermatocytes and round spermatids in males. Disruption of the tudor domain and kinase domain of STK31 respectively does not affect fertility in mice. Our data suggest that the function of STK31 may be redundant with other Tdrd proteins in germ cell development.
      Title: STK31/TDRD8, a germ cell-specific factor, is dispensable for reproduction in mice.
    4. Our findings suggest mouse STK31 could be a potential nuage-associated protein in the cytoplasm of mid-to-late spermatocytes and play pivotal roles related to fertilization.
      Title: STK31(TDRD8) is dynamically regulated throughout mouse spermatogenesis and interacts with MIWI protein.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (6)  1 citation

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2AS1 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein serine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in P granule organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in chromatin remodeling IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in piRNA processing IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within protein phosphorylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in spermatogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in P granule IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in acrosomal vesicle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    serine/threonine-protein kinase 31
    NP_001368889.1
    NP_084192.2
    XP_006506811.1
    XP_030111527.1
    XP_030111528.1
    XP_030111529.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001381960.1 → NP_001368889.1  serine/threonine-protein kinase 31 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC153385
      UniProtKB/TrEMBL
      E9Q260
      Conserved Domains (3) summary
      COG0419
      Location:274 → 670
      SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
      cd20430
      Location:38 → 112
      Tudor_TDRD8; Tudor domain found in Tudor domain-containing protein 8 (TDRD8) and similar proteins
      cl21453
      Location:780 → 899
      PKc_like; Protein Kinases, catalytic domain

    2. NM_029916.2 → NP_084192.2  serine/threonine-protein kinase 31 isoform 1

      See identical proteins and their annotated locations for NP_084192.2

      Status: VALIDATED

      Source sequence(s)
      AC153385
      Consensus CDS
      CCDS39487.1
      UniProtKB/Swiss-Prot
      B2RQM2, E9QLI8, Q99MW1
      UniProtKB/TrEMBL
      E9Q260
      Related
      ENSMUSP00000024171.8, ENSMUST00000024171.14
      Conserved Domains (3) summary
      cd04508
      Location:89 → 129
      TUDOR; Tudor domains are found in many eukaryotic organisms and have been implicated in protein-protein interactions in which methylated protein substrates bind to these domains. For example, the Tudor domain of Survival of Motor Neuron (SMN) binds to ...
      pfam00567
      Location:29 → 147
      TUDOR; Tudor domain
      cl21453
      Location:803 → 922
      PKc_like; Protein Kinases, catalytic domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000072.7 Reference GRCm39 C57BL/6J

      Range
      49372441..49446440
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030255667.2 → XP_030111527.1  serine/threonine-protein kinase 31 isoform X1

      UniProtKB/TrEMBL
      E9Q260
      Conserved Domains (3) summary
      TIGR01612
      Location:231 → 540
      235kDa-fam; reticulocyte binding/rhoptry protein
      pfam00567
      Location:35 → 146
      TUDOR; Tudor domain
      cl21453
      Location:625 → 744
      PKc_like; Protein Kinases, catalytic domain

    2. XM_030255668.2 → XP_030111528.1  serine/threonine-protein kinase 31 isoform X3

      Conserved Domains (3) summary
      TIGR01612
      Location:202 → 448
      235kDa-fam; reticulocyte binding/rhoptry protein
      pfam00567
      Location:35 → 146
      TUDOR; Tudor domain
      cl21453
      Location:533 → 652
      PKc_like; Protein Kinases, catalytic domain

    3. XM_006506748.3 → XP_006506811.1  serine/threonine-protein kinase 31 isoform X2

      See identical proteins and their annotated locations for XP_006506811.1

      UniProtKB/TrEMBL
      E9Q260
      Conserved Domains (3) summary
      COG0419
      Location:274 → 670
      SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
      cd20430
      Location:38 → 112
      Tudor_TDRD8; Tudor domain found in Tudor domain-containing protein 8 (TDRD8) and similar proteins
      cl21453
      Location:780 → 899
      PKc_like; Protein Kinases, catalytic domain

    4. XM_030255669.1 → XP_030111529.1  serine/threonine-protein kinase 31 isoform X4

      Conserved Domains (2) summary
      TIGR01612
      Location:64 → 373
      235kDa-fam; reticulocyte binding/rhoptry protein
      cl21453
      Location:458 → 577
      PKc_like; Protein Kinases, catalytic domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q99MW1.2 GenPept UniProtKB/Swiss-Prot:Q99MW1

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