LSR lipolysis stimulated lipoprotein receptor [Homo sapiens (human)] - Gene

Summary

Official Symbol: LSRprovided by HGNC
Official Full Name: lipolysis stimulated lipoprotein receptorprovided by HGNC
Primary source: HGNC:HGNC:29572
See related: Ensembl:ENSG00000105699 MIM:616582; AllianceGenome:HGNC:29572
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: ILDR3; LISCH7
Summary: Predicted to be involved in several processes, including establishment of skin barrier; protein localization to tricellular tight junction; and tricellular tight junction assembly. Located in plasma membrane and tight junction. [provided by Alliance of Genome Resources, Nov 2024]
Expression: Broad expression in stomach (RPKM 52.0), colon (RPKM 51.5) and 22 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 19q13.12

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	19	NC_000019.10 (35249002..35267964)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	19	NC_060943.1 (37793654..37812636)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	19	NC_000019.9 (35739905..35758867)

Chromosome 19 - NC_000019.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Downregulation of angulin-1/LSR induces malignancy via upregulation of EGF-dependent claudin-2 and TGF-beta-dependent cell metabolism in human lung adenocarcinoma A549 cells.
Title: Downregulation of angulin-1/LSR induces malignancy via upregulation of EGF-dependent claudin-2 and TGF-β-dependent cell metabolism in human lung adenocarcinoma A549 cells.
LSR Promotes Cell Proliferation and Invasion in Lung Cancer.
Title: LSR Promotes Cell Proliferation and Invasion in Lung Cancer.
Translocation of LSR from tricellular corners causes macropinocytosis at cell-cell interface as a trigger for breaking out of contact inhibition.
Title: Translocation of LSR from tricellular corners causes macropinocytosis at cell-cell interface as a trigger for breaking out of contact inhibition.
Potentiation of cancerous progression by LISCH7 via direct stimulation of TGFB1 transcription in triple-negative breast cancer.
Title: Potentiation of cancerous progression by LISCH7 via direct stimulation of TGFB1 transcription in triple-negative breast cancer.
LSR promotes epithelial ovarian cancer cell survival under energy stress through the LKB1-AMPK pathway.
Title: LSR promotes epithelial ovarian cancer cell survival under energy stress through the LKB1-AMPK pathway.
Leptin Downregulates Angulin-1 in Active Crohn's Disease via STAT3.
Title: Leptin Downregulates Angulin-1 in Active Crohn's Disease via STAT3.
HMGB1-downregulated angulin-1/LSR induces epithelial barrier disruption via claudin-2 and cellular metabolism via AMPK in airway epithelial Calu-3 cells.
Title: HMGB1-downregulated angulin-1/LSR induces epithelial barrier disruption via claudin-2 and cellular metabolism via AMPK in airway epithelial Calu-3 cells.
ASPP2 suppression promotes malignancy via LSR and YAP in human endometrial cancer.
Title: ASPP2 suppression promotes malignancy via LSR and YAP in human endometrial cancer.
Localization of Tricellular Tight Junction Molecule LSR at Midbody and Centrosome During Cytokinesis in Human Epithelial Cells.
Title: Localization of Tricellular Tight Junction Molecule LSR at Midbody and Centrosome During Cytokinesis in Human Epithelial Cells.
In pancreatic cancer, LSR contributes to the epithelial barrier and malignancy via growth factors and may be a potential targeting molecule in the therapy.
Title: Tricellular tight junction protein LSR/angulin-1 contributes to the epithelial barrier and malignancy in human pancreatic cancer cell line.

Submit: New GeneRIF Correction See all GeneRIFs (22)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH48421 (e-PCR)
- UniSTS:46921

RH68134 (e-PCR)
- UniSTS:19117

Gene Ontology Provided by GOA

Process	Evidence Code	Pubs
involved_in epithelial structure maintenance	ISS Inferred from Sequence or Structural Similarity more info
involved_in establishment of blood-brain barrier	IBA Inferred from Biological aspect of Ancestor more info
involved_in establishment of blood-brain barrier	ISS Inferred from Sequence or Structural Similarity more info
involved_in establishment of skin barrier	ISS Inferred from Sequence or Structural Similarity more info
involved_in liver development	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within maintenance of blood-brain barrier	NAS Non-traceable Author Statement more info	PubMed
involved_in protein localization to tricellular tight junction	ISS Inferred from Sequence or Structural Similarity more info
involved_in tricellular tight junction assembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in tricellular tight junction assembly	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in bicellular tight junction	IEA Inferred from Electronic Annotation more info
located_in cell junction	IDA Inferred from Direct Assay more info
part_of chylomicron	IEA Inferred from Electronic Annotation more info
located_in extracellular exosome	HDA more info	PubMed
part_of low-density lipoprotein particle	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in tight junction	IDA Inferred from Direct Assay more info	PubMed
is_active_in tricellular tight junction	IBA Inferred from Biological aspect of Ancestor more info
located_in tricellular tight junction	ISS Inferred from Sequence or Structural Similarity more info
part_of very-low-density lipoprotein particle	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: lipolysis-stimulated lipoprotein receptor

Names: LISCH protein; angulin-1; immunoglobulin-like domain containing receptor 3; lipolysis-stimulated remnant; liver-specific bHLH-Zip transcription factor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001260489.2 → NP_001247418.2 lipolysis-stimulated lipoprotein receptor isoform 4 precursor

Status: VALIDATED

Description

Transcript Variant: This variant (4) uses an alternate splice site in the coding region, but maintains the reading frame, compared to variant 1. The encoded isoform (4) is shorter than isoform 1.

Source sequence(s)

AC002128, AD000684

Consensus CDS

CCDS59376.2

UniProtKB/TrEMBL

A0A8Z5DL71, Q9BWS2

Related

ENSP00000472569.2, ENST00000602122.5

Conserved Domains (1) summary

PHA03307
Location:243 → 538

PHA03307; transcriptional regulator ICP4; Provisional
NM_001260490.2 → NP_001247419.2 lipolysis-stimulated lipoprotein receptor isoform 5 precursor

Status: VALIDATED

Description

Transcript Variant: This variant (5) lacks two consecutive exons in the coding region, but maintains the reading frame, compared to variant 1. The encoded isoform (5) is shorter than isoform 1.

Source sequence(s)

AC002128, AD000684

Consensus CDS

CCDS92587.1

UniProtKB/TrEMBL

Q9BWS2

Related

ENSP00000394479.1, ENST00000427250.5

Conserved Domains (2) summary

PHA03307
Location:154 → 450

PHA03307; transcriptional regulator ICP4; Provisional

TIGR01622
Location:371 → 485

SF-CC1; splicing factor, CC1-like family
NM_001385215.1 → NP_001372144.1 lipolysis-stimulated lipoprotein receptor isoform 6 precursor

Status: VALIDATED

Source sequence(s)

AC002128, AD000684

UniProtKB/TrEMBL

Q9BWS2

Conserved Domains (1) summary

PHA03307
Location:194 → 489

PHA03307; transcriptional regulator ICP4; Provisional
NM_015925.7 → NP_057009.4 lipolysis-stimulated lipoprotein receptor isoform 1 precursor

Status: VALIDATED

Description

Transcript Variant: This variant (1) encodes isoform 1.

Source sequence(s)

AC002128, AD000684

Consensus CDS

CCDS12449.2

UniProtKB/TrEMBL

A0A8Z5ABK9, Q9BWS2

Related

ENSP00000346976.3, ENST00000354900.7

Conserved Domains (1) summary

PHA03307
Location:243 → 539

PHA03307; transcriptional regulator ICP4; Provisional
NM_205834.4 → NP_991403.2 lipolysis-stimulated lipoprotein receptor isoform 2 precursor

Status: VALIDATED

Description

Transcript Variant: This variant (2) includes an alternate exon in the coding region, but maintains the reading frame, compared to variant 1. The encoded isoform (2) is longer than isoform 1.

Source sequence(s)

AC002128, AD000684

Consensus CDS

CCDS12450.2

UniProtKB/TrEMBL

Q9BWS2, S4R3V8

Related

ENSP00000474797.2, ENST00000605618.6

Conserved Domains (1) summary

PHA03307
Location:262 → 558

PHA03307; transcriptional regulator ICP4; Provisional
NM_205835.4 → NP_991404.2 lipolysis-stimulated lipoprotein receptor isoform 3 precursor

Status: VALIDATED

Description

Transcript Variant: This variant (3) lacks an exon in the coding region, but maintains the reading frame, compared to variant 1. The encoded isoform (3) is shorter than isoform 1.

Source sequence(s)

AC002128, AD000684

Consensus CDS

CCDS12451.2

UniProtKB/TrEMBL

A0A8Z5AA41, Q9BWS2

Related

ENSP00000354034.3, ENST00000360798.7

Conserved Domains (1) summary

PHA03307
Location:194 → 490

PHA03307; transcriptional regulator ICP4; Provisional

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000019.10 Reference GRCh38.p14 Primary Assembly

Range

35249002..35267964

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_005258980.3 → XP_005259037.2 lipolysis-stimulated lipoprotein receptor isoform X1

Related

ENSP00000262627.3, ENST00000347609.8
XM_011527026.3 → XP_011525328.2 lipolysis-stimulated lipoprotein receptor isoform X2
XM_047438920.1 → XP_047294876.1 lipolysis-stimulated lipoprotein receptor isoform X3
XM_047438921.1 → XP_047294877.1 lipolysis-stimulated lipoprotein receptor isoform X4

Alternate T2T-CHM13v2.0

Genomic

NC_060943.1 Alternate T2T-CHM13v2.0

Range

37793654..37812636

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_054321193.1 → XP_054177168.1 lipolysis-stimulated lipoprotein receptor isoform X1
XM_054321194.1 → XP_054177169.1 lipolysis-stimulated lipoprotein receptor isoform X2
XM_054321195.1 → XP_054177170.1 lipolysis-stimulated lipoprotein receptor isoform X3
XM_054321196.1 → XP_054177171.1 lipolysis-stimulated lipoprotein receptor isoform X4