Sis sucrase isomaltase [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Sisprovided by MGI
Official Full Name: sucrase isomaltaseprovided by MGI
Primary source: MGI:MGI:1917233
See related: Ensembl:ENSMUSG00000027790 AllianceGenome:MGI:1917233
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: SI; Si-s; 2010204N08Rik
Summary: Predicted to enable alpha-1,4-glucosidase activity; beta-fructofuranosidase activity; and oligo-1,6-glucosidase activity. Predicted to be involved in sucrose catabolic process. Located in membrane. Is expressed in intestine. Human ortholog(s) of this gene implicated in congenital sucrase-isomaltase deficiency. Orthologous to human SI (sucrase-isomaltase). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in large intestine adult (RPKM 52.6), small intestine adult (RPKM 9.9) and 1 other tissue See more
Orthologs: human all
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Genomic context

Location:: 3 E3; 3 32.59 cM

Exon count:: 48

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	3	NC_000069.7 (72795890..72875196, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	3	NC_000069.6 (72888557..72967863, complement)

Chromosome 3 - NC_000069.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The effect of sucrase-isomaltase deficiency on metabolism, food intake and preferences: protocol for a dietary intervention study.
Title: The effect of sucrase-isomaltase deficiency on metabolism, food intake and preferences: protocol for a dietary intervention study.
Core2 O-glycan structure is essential for expression of SI and DDP-IV during intestinal cell differentiation.
Title: Core2 O-glycan structure is essential for the cell surface expression of sucrase isomaltase and dipeptidyl peptidase-IV during intestinal cell differentiation.
These suggest that induction of SI gene by the diet rich in carbohydrate is associated with acetylation of histone H3 and H4 as well as binding of HNF-1 and Cdx-2 on SI gene.
Title: Carbohydrate/fat ratio in the diet alters histone acetylation on the sucrase-isomaltase gene and its expression in mouse small intestine.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)

General gene information

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Markers

Si-s (e-PCR), detects polymorphism
- UniSTS:144403

NoName (e-PCR)
- UniSTS:548142

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables alpha-1,4-glucosidase activity	IBA Inferred from Biological aspect of Ancestor more info
enables beta-fructofuranosidase activity	ISO Inferred from Sequence Orthology more info
enables oligo-1,6-glucosidase activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in sucrose catabolic process	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in brush border	ISO Inferred from Sequence Orthology more info
located_in brush border	TAS Traceable Author Statement more info	PubMed
located_in membrane	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: sucrase-isomaltase, intestinal

Names: alpha-glucosidase; sucrase isomaltase, structural

NP_001074606.1

EC 3.2.1.10

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001081137.2 → NP_001074606.1 sucrase-isomaltase, intestinal

See identical proteins and their annotated locations for NP_001074606.1

Status: VALIDATED

Source sequence(s)

AC102399, AC164406

Consensus CDS

CCDS38454.1

UniProtKB/TrEMBL

B5THE3, F8VQM5

Related

ENSMUSP00000129116.2, ENSMUST00000167334.8

Conserved Domains (6) summary

smart00018
Location:925 → 971

PD; P or trefoil or TFF domain

cd06602
Location:333 → 697

GH31_MGAM_SI_GAA; maltase-glucoamylase, sucrase-isomaltase, lysosomal acid alpha-glucosidase

cd14752
Location:217 → 333

GH31_N; N-terminal domain of glycosyl hydrolase family 31 (GH31)

pfam00088
Location:60 → 98

Trefoil; Trefoil (P-type) domain

pfam01055
Location:314 → 787

Glyco_hydro_31; Glycosyl hydrolases family 31

pfam16863
Location:115 → 224

NtCtMGAM_N; N-terminal barrel of NtMGAM and CtMGAM, maltase-glucoamylase