Rspo3 R-spondin 3 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Rspo3provided by MGI
Official Full Name: R-spondin 3provided by MGI
Primary source: MGI:MGI:1920030
See related: Ensembl:ENSMUSG00000019880 AllianceGenome:MGI:1920030
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Thsd2; Cristin1; 2810459H04Rik
Summary: Enables frizzled binding activity and heparin binding activity. Involved in blood vessel remodeling; positive regulation of non-canonical Wnt signaling pathway; and sprouting angiogenesis. Acts upstream of or within angiogenesis; branching involved in labyrinthine layer morphogenesis; and positive regulation of canonical Wnt signaling pathway. Located in extracellular region. Is expressed in several structures, including embryo ectoderm; genitourinary system; heart; limb; and skeleton. Orthologous to human RSPO3 (R-spondin 3). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Broad expression in adrenal adult (RPKM 11.5), ovary adult (RPKM 5.6) and 20 other tissues See more
Orthologs: human all
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Genomic context

Location:: 10 A4; 10 16.64 cM

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	10	NC_000076.7 (29329102..29411863, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	10	NC_000076.6 (29453106..29535867, complement)

Chromosome 10 - NC_000076.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Endothelial RSPO3 mediates pulmonary endothelial regeneration by LGR4-dependent activation of beta-catenin and ILK signaling pathways after inflammatory vascular injury.
Title: Endothelial RSPO3 mediates pulmonary endothelial regeneration by LGR4-dependent activation of β-catenin and ILK signaling pathways after inflammatory vascular injury.
Rspo1 and Rspo3 are required for sensory lineage neural crest formation in mouse embryos.
Title: Rspo1 and Rspo3 are required for sensory lineage neural crest formation in mouse embryos.
Increased R-spondin 3 contributes to aerobic exercise-induced protection against renal vascular endothelial hyperpermeability and acute kidney injury.
Title: Increased R-spondin 3 contributes to aerobic exercise-induced protection against renal vascular endothelial hyperpermeability and acute kidney injury.
R-spondin-3 promotes proliferation and invasion of breast cancer cells independently of Wnt signaling.
Title: R-spondin-3 promotes proliferation and invasion of breast cancer cells independently of Wnt signaling.
R-spondin 3/LGR4 (Leucine-Rich Repeat-Containing G Protein-Coupled Receptor 4) Axis Is a Novel Inflammatory and Neurite Outgrowth Signaling System in the Ischemic Brain in Mice.
Title: R-spondin 3/LGR4 (Leucine-Rich Repeat-Containing G Protein-Coupled Receptor 4) Axis Is a Novel Inflammatory and Neurite Outgrowth Signaling System in the Ischemic Brain in Mice.
R-spondin/YAP axis promotes gastric oxyntic gland regeneration and Helicobacter pylori-associated metaplasia in mice.
Title: R-spondin/YAP axis promotes gastric oxyntic gland regeneration and Helicobacter pylori-associated metaplasia in mice.
R-spondin 3 deletion induces Erk phosphorylation to enhance Wnt signaling and promote bone formation in the appendicular skeleton.
Title: R-spondin 3 deletion induces Erk phosphorylation to enhance Wnt signaling and promote bone formation in the appendicular skeleton.
R-spondin-3 is an oncogenic driver of poorly differentiated invasive breast cancer.
Title: R-spondin-3 is an oncogenic driver of poorly differentiated invasive breast cancer.
R-spondin3 is a myokine that differentiates myoblasts to type I fibres.
Title: R-spondin3 is a myokine that differentiates myoblasts to type I fibres.
Synergistic roles of Wnt modulators R-spondin2 and R-spondin3 in craniofacial morphogenesis and dental development.
Title: Synergistic roles of Wnt modulators R-spondin2 and R-spondin3 in craniofacial morphogenesis and dental development.

Submit: New GeneRIF Correction See all GeneRIFs (30)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)
Targeted (6) 1 citation

General gene information

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Markers

Rspo3 (e-PCR), detects polymorphism
- UniSTS:532287

AW742308 (e-PCR)
- UniSTS:208506

Rspo3 (e-PCR), detects polymorphism
- UniSTS:497309

NoName (e-PCR)
- UniSTS:491996

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables frizzled binding	IBA Inferred from Biological aspect of Ancestor more info
enables frizzled binding	IPI Inferred from Physical Interaction more info	PubMed
enables heparin binding	IDA Inferred from Direct Assay more info	PubMed
enables signaling receptor binding	IPI Inferred from Physical Interaction more info	PubMed
enables signaling receptor binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within angiogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in blood vessel remodeling	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within branching involved in labyrinthine layer morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of canonical Wnt signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in limb development	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of Wnt signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of canonical Wnt signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within positive regulation of canonical Wnt signaling pathway	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within positive regulation of canonical Wnt signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of non-canonical Wnt signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in sprouting angiogenesis	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in extracellular region	IDA Inferred from Direct Assay more info	PubMed
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: R-spondin-3

Names: R-spondin 3 homolog; cabriolet; cristin 1; cysteine-rich and single thrombospondin domain-containing protein 1; nucleopondin; roof plate-specific spondin-3; thrombospondin, type I, domain 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_028351.3 → NP_082627.3 R-spondin-3 precursor

See identical proteins and their annotated locations for NP_082627.3

Status: VALIDATED

Source sequence(s)

AK133916, BC103794

Consensus CDS

CCDS23761.1

UniProtKB/Swiss-Prot

A6H6M4, Q2TJ95, Q3SYI9, Q5R2V4, Q8BVW2, Q9CSB2

Related

ENSMUSP00000090287.4, ENSMUST00000092623.5

Conserved Domains (3) summary

smart00209
Location:151 → 202

TSP1; Thrombospondin type 1 repeats

cd00064
Location:97 → 143

FU; Furin-like repeats. Cysteine rich region. Exact function of the domain is not known. Furin is a serine-kinase dependent proprotein processor. Other members of this family include endoproteases and cell surface receptors.

pfam15913
Location:42 → 144

Furin-like_2; Furin-like repeat, cysteine-rich