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    Tbc1d14 TBC1 domain family, member 14 [ Mus musculus (house mouse) ]

    Gene ID: 100855, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Tbc1d14provided by MGI
    Official Full Name
    TBC1 domain family, member 14provided by MGI
    Primary source
    MGI:MGI:1098708
    See related
    Ensembl:ENSMUSG00000029192 AllianceGenome:MGI:1098708
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    mKIAA1322; D5Ertd110e; 2810413P16Rik
    Summary
    Predicted to enable GTPase activator activity and protein kinase binding activity. Predicted to be involved in negative regulation of autophagy; recycling endosome to Golgi transport; and regulation of autophagosome assembly. Predicted to be located in Golgi apparatus and nucleoplasm. Predicted to be active in autophagosome and recycling endosome. Is expressed in cortical plate and metanephros. Orthologous to human TBC1D14 (TBC1 domain family member 14). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in CNS E18 (RPKM 21.3), testis adult (RPKM 18.7) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Tbc1d14 in Genome Data Viewer
    Location:
    5 B3; 5 19.15 cM
    Exon count:
    22
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (36647948..36743611, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (36490604..36586271, complement)

    Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene GrpE-like 1, mitochondrial Neighboring gene STARR-positive B cell enhancer ABC_E3572 Neighboring gene transcriptional adaptor 2B Neighboring gene coiled-coil domain containing 96 Neighboring gene predicted gene, 32528 Neighboring gene CapStarr-seq enhancer MGSCv37_chr5:36872352-36872539 Neighboring gene STARR-positive B cell enhancer ABC_E6323 Neighboring gene STARR-positive B cell enhancer ABC_E10317 Neighboring gene STARR-positive B cell enhancer ABC_E4753 Neighboring gene DNA segment, Chr 5, ERATO Doi 579, expressed Neighboring gene predicted gene, 32584 Neighboring gene predicted gene, 24878

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. CLICK: one-step generation of conditional knockout mice. Miyasaka Y, et al. BMC Genomics, 2018 May 2. PMID 29720086, Free PMC Article
    2. High resolution mapping and positional cloning of ENU-induced mutations in the Rw region of mouse chromosome 5. Ching YH, et al. BMC Genet, 2010 Nov 30. PMID 21118569, Free PMC Article
    3. Random mutagenesis of proximal mouse chromosome 5 uncovers predominantly embryonic lethal mutations. Wilson L, et al. Genome Res, 2005 Aug. PMID 16024820, Free PMC Article
    4. Prediction of the coding sequences of mouse homologues of KIAA gene: I. The complete nucleotide sequences of 100 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. Okazaki N, et al. DNA Res, 2002 Oct 31. PMID 12465718
    5. BioID screening of biotinylation sites using the avidin-like protein Tamavidin 2-REV identifies global interactors of stimulator of interferon genes (STING). Motani K, et al. J Biol Chem, 2020 Aug 7. PMID 32554809, Free PMC Article

    See all (23) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC102624

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables GTPase activator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GTPase activator activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein kinase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in negative regulation of autophagy ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in recycling endosome to Golgi transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of autophagosome assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of autophagosome assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in autophagosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in autophagosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in recycling endosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in recycling endosome ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    TBC1 domain family member 14

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001113362.1 → NP_001106833.1  TBC1 domain family member 14 isoform a

      See identical proteins and their annotated locations for NP_001106833.1

      Status: VALIDATED

      Source sequence(s)
      AK029986, BC086316, BC096446
      Consensus CDS
      CCDS51480.1
      UniProtKB/Swiss-Prot
      Q3V2L6, Q4VAC6, Q8CGA2, Q8CHA5
      UniProtKB/TrEMBL
      G3UVU5
      Related
      ENSMUSP00000116519.2, ENSMUST00000130417.8
      Conserved Domains (2) summary
      smart00164
      Location:419 → 651
      TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs
      pfam15346
      Location:350 → 392
      ARGLU; Arginine and glutamate-rich 1

    2. NM_001113364.1 → NP_001106835.1  TBC1 domain family member 14 isoform c

      See identical proteins and their annotated locations for NP_001106835.1

      Status: VALIDATED

      Source sequence(s)
      AB064521, BC086316, BC096446, BQ745653
      Consensus CDS
      CCDS51479.1
      UniProtKB/TrEMBL
      E9PYB1, Q76LY3
      Related
      ENSMUSP00000131876.2, ENSMUST00000171385.8
      Conserved Domains (2) summary
      smart00164
      Location:118 → 350
      TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs
      pfam17664
      Location:9 → 88
      DUF5526; Family of unknown function (DUF5526)

    3. NM_133910.3 → NP_598671.3  TBC1 domain family member 14 isoform b

      See identical proteins and their annotated locations for NP_598671.3

      Status: VALIDATED

      Source sequence(s)
      BC086316, BC096446, BQ769916
      Consensus CDS
      CCDS19240.2
      UniProtKB/Swiss-Prot
      Q3V2L6, Q4VAC6, Q8CGA2, Q8CHA5
      UniProtKB/TrEMBL
      E9Q8K4
      Related
      ENSMUSP00000031094.9, ENSMUST00000031094.15
      Conserved Domains (2) summary
      smart00164
      Location:399 → 631
      TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs
      pfam15346
      Location:330 → 369
      ARGLU; Arginine and glutamate-rich 1

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000071.7 Reference GRCm39 C57BL/6J

      Range
      36647948..36743611 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006503645.1 → XP_006503708.1  TBC1 domain family member 14 isoform X5

      See identical proteins and their annotated locations for XP_006503708.1

      UniProtKB/TrEMBL
      E9PYB1, Q76LY3
      Related
      ENSMUSP00000114508.2, ENSMUST00000126077.8
      Conserved Domains (2) summary
      smart00164
      Location:118 → 350
      TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs
      pfam17664
      Location:9 → 88
      DUF5526; Family of unknown function (DUF5526)

    2. XM_006503640.4 → XP_006503703.1  TBC1 domain family member 14 isoform X1

      See identical proteins and their annotated locations for XP_006503703.1

      UniProtKB/Swiss-Prot
      Q3V2L6, Q4VAC6, Q8CGA2, Q8CHA5
      UniProtKB/TrEMBL
      G3UVU5
      Related
      ENSMUSP00000117414.2, ENSMUST00000124036.8
      Conserved Domains (2) summary
      smart00164
      Location:419 → 651
      TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs
      pfam15346
      Location:350 → 392
      ARGLU; Arginine and glutamate-rich 1

    3. XM_006503641.5 → XP_006503704.1  TBC1 domain family member 14 isoform X3

      See identical proteins and their annotated locations for XP_006503704.1

      UniProtKB/Swiss-Prot
      Q3V2L6, Q4VAC6, Q8CGA2, Q8CHA5
      UniProtKB/TrEMBL
      E9Q8K4
      Related
      ENSMUSP00000121516.2, ENSMUST00000140607.8
      Conserved Domains (2) summary
      smart00164
      Location:399 → 631
      TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs
      pfam15346
      Location:330 → 369
      ARGLU; Arginine and glutamate-rich 1

    4. XM_036164700.1 → XP_036020593.1  TBC1 domain family member 14 isoform X3

      UniProtKB/Swiss-Prot
      Q3V2L6, Q4VAC6, Q8CGA2, Q8CHA5
      UniProtKB/TrEMBL
      E9Q8K4
      Conserved Domains (2) summary
      smart00164
      Location:399 → 631
      TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs
      pfam15346
      Location:330 → 369
      ARGLU; Arginine and glutamate-rich 1

    5. XM_006503642.5 → XP_006503705.1  TBC1 domain family member 14 isoform X3

      See identical proteins and their annotated locations for XP_006503705.1

      UniProtKB/Swiss-Prot
      Q3V2L6, Q4VAC6, Q8CGA2, Q8CHA5
      UniProtKB/TrEMBL
      E9Q8K4
      Conserved Domains (2) summary
      smart00164
      Location:399 → 631
      TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs
      pfam15346
      Location:330 → 369
      ARGLU; Arginine and glutamate-rich 1

    6. XM_036164699.1 → XP_036020592.1  TBC1 domain family member 14 isoform X2

      UniProtKB/Swiss-Prot
      Q3V2L6, Q4VAC6, Q8CGA2, Q8CHA5
      Related
      ENSMUSP00000115467.2, ENSMUST00000136189.8
      Conserved Domains (1) summary
      smart00164
      Location:399 → 607
      TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs

    7. XM_036164703.1 → XP_036020596.1  TBC1 domain family member 14 isoform X7

      UniProtKB/TrEMBL
      Q76LY3, Q921M0
      Conserved Domains (1) summary
      smart00164
      Location:58 → 290
      TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs

    8. XM_006503644.5 → XP_006503707.1  TBC1 domain family member 14 isoform X4

      See identical proteins and their annotated locations for XP_006503707.1

      UniProtKB/TrEMBL
      Q76LY3
      Conserved Domains (1) summary
      smart00164
      Location:169 → 401
      TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs

    9. XM_036164702.1 → XP_036020595.1  TBC1 domain family member 14 isoform X6

      UniProtKB/TrEMBL
      Q76LY3
      Conserved Domains (1) summary
      smart00164
      Location:118 → 326
      TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs

    10. XM_036164704.1 → XP_036020597.1  TBC1 domain family member 14 isoform X7

      UniProtKB/TrEMBL
      Q76LY3, Q921M0
      Conserved Domains (1) summary
      smart00164
      Location:58 → 290
      TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs

    11. XM_006503647.5 → XP_006503710.1  TBC1 domain family member 14 isoform X7

      See identical proteins and their annotated locations for XP_006503710.1

      UniProtKB/TrEMBL
      Q76LY3, Q921M0
      Conserved Domains (1) summary
      smart00164
      Location:58 → 290
      TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs

    RNA

    1. XR_004942417.1 RNA Sequence

    2. XR_376793.3 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8CGA2.2 GenPept UniProtKB/Swiss-Prot:Q8CGA2

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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