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    Cd248 CD248 antigen, endosialin [ Mus musculus (house mouse) ]

    Gene ID: 70445, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Cd248provided by MGI
    Official Full Name
    CD248 antigen, endosialinprovided by MGI
    Primary source
    MGI:MGI:1917695
    See related
    Ensembl:ENSMUSG00000056481 AllianceGenome:MGI:1917695
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Tem1; Cd164l1; 2610111G01Rik
    Summary
    Enables extracellular matrix binding activity. Acts upstream of or within several processes, including fibroblast migration; lymph node development; and positive regulation of endothelial cell apoptotic process. Located in cytoplasm. Is expressed in several structures, including alimentary system; genitourinary system; hemolymphoid system; integumental system; and skeleton. Orthologous to human CD248 (CD248 molecule). [provided by Alliance of Genome Resources, Nov 2024]
    Orthologs
    human all
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    Genomic context

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    See Cd248 in Genome Data Viewer
    Location:
    19 A; 19 4.24 cM
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (5118106..5120668)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (5068078..5070640)

    Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene CapStarr-seq enhancer MGSCv37_chr19:5041192-5041379 Neighboring gene breast cancer metastasis-suppressor 1 Neighboring gene Ras and Rab interactor 1 Neighboring gene STARR-positive B cell enhancer ABC_E1968 Neighboring gene uncharacterized LOC132660285 Neighboring gene STARR-positive B cell enhancer ABC_E7627 Neighboring gene transmembrane protein 151A Neighboring gene Yip1 interacting factor homolog A (S. cerevisiae) Neighboring gene cornichon family AMPA receptor auxiliary protein 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Genetic Deletion of the Stromal Cell Marker CD248 (Endosialin) Protects against the Development of Renal Fibrosis. Smith SW, et al. Nephron, 2015. PMID 26633297, Free PMC Article
    2. Hepatic stellate cells limit hepatocellular carcinoma progression through the orphan receptor endosialin. Mogler C, et al. EMBO Mol Med, 2017 Jun. PMID 28373218, Free PMC Article
    3. Tumor Endothelial Marker 1 (TEM1/Endosialin/CD248) Enhances Wound Healing by Interacting with Platelet-Derived Growth Factor Receptors. Hong YK, et al. J Invest Dermatol, 2019 Oct. PMID 30986375
    4. CD248 and its cytoplasmic domain: a therapeutic target for arthritis. Maia M, et al. Arthritis Rheum, 2010 Dec. PMID 20722022
    5. CD248 facilitates tumor growth via its cytoplasmic domain. Maia M, et al. BMC Cancer, 2011 May 8. PMID 21549007, Free PMC Article

    See all (58) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Regulation of matrix reloading by tumor endothelial marker 1 protects against abdominal aortic aneurysm.
      Title: Regulation of matrix reloading by tumor endothelial marker 1 protects against abdominal aortic aneurysm.
    2. IL-8 from CD248-expressing cancer-associated fibroblasts generates cisplatin resistance in non-small cell lung cancer.
      Title: IL-8 from CD248-expressing cancer-associated fibroblasts generates cisplatin resistance in non-small cell lung cancer.
    3. TEM1/endosialin/CD248 promotes pathologic scarring and TGF-beta activity through its receptor stability in dermal fibroblasts.
      Title: TEM1/endosialin/CD248 promotes pathologic scarring and TGF-β activity through its receptor stability in dermal fibroblasts.
    4. CD248 promotes insulin resistance by binding to the insulin receptor and dampening its insulin-induced autophosphorylation.
      Title: CD248 promotes insulin resistance by binding to the insulin receptor and dampening its insulin-induced autophosphorylation.
    5. Endosialin-positive tumor-derived pericytes promote tumor progression through impeding the infiltration of CD8[+] T cells in clear cell renal cell carcinoma.
      Title: Endosialin-positive tumor-derived pericytes promote tumor progression through impeding the infiltration of CD8(+) T cells in clear cell renal cell carcinoma.
    6. Sex-specific effects of CD248 on metabolism and the adipose tissue lipidome.
      Title: Sex-specific effects of CD248 on metabolism and the adipose tissue lipidome.
    7. CD248 induces a maladaptive unfolded protein response in diabetic kidney disease.
      Title: CD248 induces a maladaptive unfolded protein response in diabetic kidney disease.
    8. CD248 Regulates Wnt Signaling in Pericytes to Promote Angiogenesis and Tumor Growth in Lung Cancer.
      Title: CD248 Regulates Wnt Signaling in Pericytes to Promote Angiogenesis and Tumor Growth in Lung Cancer.
    9. Tumor endothelial marker 1 is upregulated in heart after cardiac injury and participates in cardiac remodeling.
      Title: Tumor endothelial marker 1 is upregulated in heart after cardiac injury and participates in cardiac remodeling.
    10. Efficacy of piperacillin-tazobactam and cefotaxime against Escherichia coli hyperproducing TEM-1 in a mouse peritonitis infection model.
      Title: Efficacy of piperacillin-tazobactam and cefotaxime against Escherichia coli hyperproducing TEM-1 in a mouse peritonitis infection model.
    Submit: New GeneRIF Correction See all GeneRIFs (26)

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 
    • Targeted (4)  1 citation

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables carbohydrate binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables extracellular matrix binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables extracellular matrix binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables extracellular matrix protein binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within anatomical structure regression IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cell migration IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of endothelial cell apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within fibroblast migration IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of fibroblast proliferation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within lymph node development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within positive regulation of endothelial cell apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within positive regulation of fibroblast proliferation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in external side of plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    endosialin
    Names
    CD164 sialomucin-like 1
    tumor endothelial marker 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_054042.2 → NP_473383.1  endosialin precursor

      See identical proteins and their annotated locations for NP_473383.1

      Status: VALIDATED

      Source sequence(s)
      BC046318
      Consensus CDS
      CCDS29448.1
      UniProtKB/Swiss-Prot
      Q3UMV6, Q91V98, Q91ZV1
      UniProtKB/TrEMBL
      A0A172Q386
      Related
      ENSMUSP00000070847.7, ENSMUST00000070630.8
      Conserved Domains (4) summary
      cd03600
      Location:29 → 160
      CLECT_thrombomodulin_like; C-type lectin-like domain (CTLD) of the type found in human thrombomodulin(TM), Endosialin, C14orf27, and C1qR
      smart00179
      Location:312 → 350
      EGF_CA; Calcium-binding EGF-like domain
      pfam01826
      Location:269 → 316
      TIL; Trypsin Inhibitor like cysteine rich domain
      pfam14670
      Location:235 → 271
      FXa_inhibition; Coagulation Factor Xa inhibitory site

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000085.7 Reference GRCm39 C57BL/6J

      Range
      5118106..5120668
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q91V98.1 GenPept UniProtKB/Swiss-Prot:Q91V98

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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