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    Pdk4 pyruvate dehydrogenase kinase, isoenzyme 4 [ Mus musculus (house mouse) ]

    Gene ID: 27273, updated on 11-Nov-2024

    Summary

    Official Symbol
    Pdk4provided by MGI
    Official Full Name
    pyruvate dehydrogenase kinase, isoenzyme 4provided by MGI
    Primary source
    MGI:MGI:1351481
    See related
    Ensembl:ENSMUSG00000019577 AllianceGenome:MGI:1351481
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Summary
    Predicted to enable ATP binding activity and pyruvate dehydrogenase (acetyl-transferring) kinase activity. Involved in several processes, including insulin receptor signaling pathway; regulation of bone resorption; and regulation of fatty acid metabolic process. Located in mitochondrial inner membrane. Is expressed in several structures, including brain; genitourinary system; gut; hemolymphoid system gland; and skin. Orthologous to human PDK4 (pyruvate dehydrogenase kinase 4). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in heart adult (RPKM 42.2), adrenal adult (RPKM 18.7) and 12 other tissues See more
    Orthologs
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    Genomic context

    See Pdk4 in Genome Data Viewer
    Location:
    6 A1; 6 2.06 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (5483351..5496278, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (5483351..5496278, complement)

    Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_15042 Neighboring gene predicted gene, 38762 Neighboring gene STARR-seq mESC enhancer starr_15044 Neighboring gene ankyrin repeat and SOCS box-containing 4 Neighboring gene STARR-seq mESC enhancer starr_15047 Neighboring gene STARR-seq mESC enhancer starr_15048 Neighboring gene STARR-seq mESC enhancer starr_15049 Neighboring gene STARR-seq mESC enhancer starr_15050 Neighboring gene STARR-seq mESC enhancer starr_15051 Neighboring gene STARR-seq mESC enhancer starr_15052 Neighboring gene predicted gene, 34470 Neighboring gene predicted gene, 46983

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (6) 
    • Targeted (4)  1 citation

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables ATP binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein serine/threonine/tyrosine kinase activity TAS
    Traceable Author Statement
    more info
    PubMed 
    enables pyruvate dehydrogenase (acetyl-transferring) kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables pyruvate dehydrogenase (acetyl-transferring) kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables pyruvate dehydrogenase (acetyl-transferring) kinase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Process Evidence Code Pubs
    involved_in cellular response to fatty acid ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular response to fatty acid ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in cellular response to starvation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular response to starvation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in glucose homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in insulin receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in insulin receptor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in insulin receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of anoikis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of anoikis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in phosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in reactive oxygen species metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in reactive oxygen species metabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in regulation of acetyl-CoA biosynthetic process from pyruvate IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in regulation of acetyl-CoA biosynthetic process from pyruvate IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of acetyl-CoA biosynthetic process from pyruvate ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within regulation of acetyl-CoA biosynthetic process from pyruvate TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in regulation of bone resorption IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of cellular ketone metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of fatty acid biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of fatty acid biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of fatty acid oxidation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of glucose metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in regulation of glucose metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of glucose metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of pH IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in response to starvation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in mitochondrial inner membrane HDA PubMed 
    located_in mitochondrial matrix IEA
    Inferred from Electronic Annotation
    more info
     
    located_in mitochondrion HDA PubMed 
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 4, mitochondrial
    Names
    [Pyruvate dehydrogenase [lipoamide]] kinase isozyme 4, mitochondrial
    pyruvate dehydrogenase kinase 4
    NP_038771.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_013743.2NP_038771.1  [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 4, mitochondrial

      See identical proteins and their annotated locations for NP_038771.1

      Status: PROVISIONAL

      Source sequence(s)
      AC023174
      Consensus CDS
      CCDS19902.1
      UniProtKB/Swiss-Prot
      O70571
      UniProtKB/TrEMBL
      Q544J2
      Related
      ENSMUSP00000019721.5, ENSMUST00000019721.7
      Conserved Domains (3) summary
      smart00387
      Location:245365
      HATPase_c; Histidine kinase-like ATPases
      COG0642
      Location:245373
      BaeS; Signal transduction histidine kinase [Signal transduction mechanisms]
      pfam10436
      Location:34195
      BCDHK_Adom3; Mitochondrial branched-chain alpha-ketoacid dehydrogenase kinase

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000072.7 Reference GRCm39 C57BL/6J

      Range
      5483351..5496278 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)