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    Apeh acylpeptide hydrolase [ Mus musculus (house mouse) ]

    Gene ID: 235606, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Apehprovided by MGI
    Official Full Name
    acylpeptide hydrolaseprovided by MGI
    Primary source
    MGI:MGI:88041
    See related
    Ensembl:ENSMUSG00000032590 AllianceGenome:MGI:88041
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Summary
    Predicted to enable identical protein binding activity; omega peptidase activity; and serine-type endopeptidase activity. Predicted to be involved in amyloid-beta metabolic process and proteolysis. Predicted to be located in cytosol and nuclear membrane. Is expressed in dorsal root ganglion and liver lobe. Orthologous to human APEH (acylaminoacyl-peptide hydrolase). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in kidney adult (RPKM 71.8), liver E14.5 (RPKM 55.5) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Apeh in Genome Data Viewer
    Location:
    9 F1; 9 59.07 cM
    Exon count:
    22
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (107962613..107971736, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (108085413..108094490, complement)

    Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E3859 Neighboring gene ring finger protein 123 Neighboring gene adhesion molecule with Ig like domain 3 Neighboring gene microRNA 7088 Neighboring gene STARR-positive B cell enhancer ABC_E2914 Neighboring gene macrophage stimulating 1 (hepatocyte growth factor-like) Neighboring gene bassoon Neighboring gene RIKEN cDNA 4930447F24 gene Neighboring gene glycine cleavage system protein H (aminomethyl carrier) pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Acyl Peptide Enzyme Hydrolase (APEH) activity is inhibited by lipid metabolites and peroxidation products. Tyler K, et al. Chem Biol Interact, 2021 Oct 1. PMID 34508712
    2. Characterization of the mouse cDNA and gene coding for a hepatocyte growth factor-like protein: expression during development. Degen SJ, et al. Biochemistry, 1991 Oct 8. PMID 1832957
    3. Ectopic expression of DNA methyltransferases DNMT3A2 and DNMT3L leads to aberrant hypermethylation and postnatal lethality in mice. Sasaki K, et al. Mol Reprod Dev, 2019 Jun. PMID 30834655, Free PMC Article
    4. Report of the sixth international workshop on human chromosome 3 mapping 1995. Naylor SL, et al. Cytogenet Cell Genet, 1996. PMID 8641130
    5. Fv2 encodes a truncated form of the Stk receptor tyrosine kinase. Persons DA, et al. Nat Genet, 1999 Oct. PMID 10508511

    See all (25) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Acyl Peptide Enzyme Hydrolase (APEH) activity is inhibited by lipid metabolites and peroxidation products.
      Title: Acyl Peptide Enzyme Hydrolase (APEH) activity is inhibited by lipid metabolites and peroxidation products.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (2) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC38101

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables identical protein binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables omega peptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables omega peptidase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables serine-type endopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables serine-type endopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables serine-type endopeptidase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in amyloid-beta metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in amyloid-beta metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in proteolysis ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nuclear membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nuclear membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    acylamino-acid-releasing enzyme
    Names
    AARE
    APH
    N-acylaminoacyl peptide hydrolase
    acyl-peptide hydrolase
    acylaminoacyl-peptidase
    NP_001397427.1
    NP_001397428.1
    NP_001397429.1
    NP_666338.2
    XP_030100204.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001410498.1 → NP_001397427.1  acylamino-acid-releasing enzyme isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC137678
      Related
      ENSMUSP00000080058.9, ENSMUST00000081309.13

    2. NM_001410499.1 → NP_001397428.1  acylamino-acid-releasing enzyme isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC137678

    3. NM_001410500.1 → NP_001397429.1  acylamino-acid-releasing enzyme isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC137678

    4. NM_146226.3 → NP_666338.2  acylamino-acid-releasing enzyme isoform 1

      See identical proteins and their annotated locations for NP_666338.2

      Status: VALIDATED

      Source sequence(s)
      AC137678
      Consensus CDS
      CCDS52923.1
      UniProtKB/Swiss-Prot
      G3X9I2, Q8K029, Q8R0M9, Q8R146
      UniProtKB/TrEMBL
      A0A0R4J107
      Related
      ENSMUSP00000141856.2, ENSMUST00000193254.6
      Conserved Domains (2) summary
      pfam00561
      Location:501 → 713
      Abhydrolase_1; alpha/beta hydrolase fold
      cl21494
      Location:510 → 707
      Abhydrolase; alpha/beta hydrolases

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000075.7 Reference GRCm39 C57BL/6J

      Range
      107962613..107971736 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030244344.2 → XP_030100204.1  acylamino-acid-releasing enzyme isoform X2

      Conserved Domains (1) summary
      COG1506
      Location:22 → 597
      DAP2; Dipeptidyl aminopeptidase/acylaminoacyl peptidase [Amino acid transport and metabolism]
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8R146.3 GenPept UniProtKB/Swiss-Prot:Q8R146

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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