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    WDR25 WD repeat domain 25 [ Homo sapiens (human) ]

    Gene ID: 79446, updated on 19-Sep-2024

    Summary

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    Official Symbol
    WDR25provided by HGNC
    Official Full Name
    WD repeat domain 25provided by HGNC
    Primary source
    HGNC:HGNC:21064
    See related
    Ensembl:ENSG00000176473 MIM:618059; AllianceGenome:HGNC:21064
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    C14orf67
    Summary
    This gene encodes a protein containing 7 WD repeats. WD repeats are approximately 30 to 40-amino acid domains containing several conserved residues, typically having a Tryptophan-Aspartic acid dipeptide (WD) at the C-terminal end. WD domains are involved in protein-protein interactions in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2017]
    Expression
    Ubiquitous expression in thyroid (RPKM 3.8), testis (RPKM 2.7) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See WDR25 in Genome Data Viewer
    Location:
    14q32.2
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 14 NC_000014.9 (100376485..100530303)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 14 NC_060938.1 (94609583..94764104)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (100842822..100996640)

    Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9038 Neighboring gene solute carrier family 25 member 47 Neighboring gene tryptophanyl-tRNA synthetase 1 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:100837597-100838513 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9039 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9040 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6090 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6091 Neighboring gene NADH:ubiquinone oxidoreductase subunit B3 pseudogene 4 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:100848141-100849101 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:100849328-100849837 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:100860083-100860587 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr14:100863901-100865100 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:100870227-100870728 Neighboring gene uncharacterized LOC105370664 Neighboring gene H3K27ac hESC enhancer GRCh37_chr14:100876203-100876704 Neighboring gene H3K27ac hESC enhancer GRCh37_chr14:100876705-100877204 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:100885967-100886468 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:100886469-100886968 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:100893614-100894278 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr14:100904917-100906116 Neighboring gene Sharpr-MPRA regulatory region 12420 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:100913795-100914295 Neighboring gene uncharacterized LOC124903383 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:100932314-100933219 Neighboring gene high mobility group nucleosome binding domain 1 pseudogene 25 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:100966138-100966638 Neighboring gene RN7SK pseudogene 92 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:100989077-100989737 Neighboring gene uncharacterized LOC124903382 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9041 Neighboring gene uncharacterized LOC124903384 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:101021873-101022628 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:101022629-101023385 Neighboring gene brain enriched guanylate kinase associated

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. A novel human gene (WDR25) encoding a 7-WD40-containing protein maps on 14q32. Jin F, et al. Biochem Genet, 2004 Dec. PMID 15587985
    2. Notch3 interactome analysis identified WWP2 as a negative regulator of Notch3 signaling in ovarian cancer. Jung JG, et al. PLoS Genet, 2014 Oct. PMID 25356737, Free PMC Article
    3. Parent-of-origin-specific allelic associations among 106 genomic loci for age at menarche. Perry JR, et al. Nature, 2014 Oct 2. PMID 25231870, Free PMC Article
    4. The Eyes Absent family members EYA4 and EYA1 promote PLK1 activation and successful mitosis through tyrosine dephosphorylation. Nelson CB, et al. Nat Commun, 2024 Feb 15. PMID 38360978, Free PMC Article
    5. A Role for Mitochondrial Translation in Promotion of Viability in K-Ras Mutant Cells. Martin TD, et al. Cell Rep, 2017 Jul 11. PMID 28700943, Free PMC Article

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    Parent-of-origin-specific allelic associations among 106 genomic loci for age at menarche.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC4645

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    WD repeat-containing protein 25
    Names
    epididymis secretory sperm binding protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_053195.1 RefSeqGene

      Range
      5076..158894
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001161476.3 → NP_001154948.1  WD repeat-containing protein 25 isoform a

      See identical proteins and their annotated locations for NP_001154948.1

      Status: REVIEWED

      Source sequence(s)
      AL135838, AL845552
      Consensus CDS
      CCDS32157.1
      UniProtKB/Swiss-Prot
      A8K7E5, Q64LD2, Q6NVV6, Q86TQ4, Q9BTK5
      UniProtKB/TrEMBL
      A0A384NPW5
      Related
      ENSP00000385540.3, ENST00000402312.8
      Conserved Domains (2) summary
      sd00039
      Location:251 → 290
      7WD40; WD40 repeat [structural motif]
      cl29593
      Location:239 → 543
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    2. NM_001350947.2 → NP_001337876.1  WD repeat-containing protein 25 isoform a

      Status: REVIEWED

      Source sequence(s)
      AL135838, AL845552
      Consensus CDS
      CCDS32157.1
      UniProtKB/Swiss-Prot
      A8K7E5, Q64LD2, Q6NVV6, Q86TQ4, Q9BTK5
      UniProtKB/TrEMBL
      A0A384NPW5
      Conserved Domains (2) summary
      sd00039
      Location:251 → 290
      7WD40; WD40 repeat [structural motif]
      cl29593
      Location:239 → 543
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    3. NM_001350948.2 → NP_001337877.1  WD repeat-containing protein 25 isoform a

      Status: REVIEWED

      Source sequence(s)
      AL135838, AL845552
      Consensus CDS
      CCDS32157.1
      UniProtKB/Swiss-Prot
      A8K7E5, Q64LD2, Q6NVV6, Q86TQ4, Q9BTK5
      UniProtKB/TrEMBL
      A0A384NPW5
      Related
      ENSP00000450661.1, ENST00000554998.5
      Conserved Domains (2) summary
      sd00039
      Location:251 → 290
      7WD40; WD40 repeat [structural motif]
      cl29593
      Location:239 → 543
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    4. NM_001350949.2 → NP_001337878.1  WD repeat-containing protein 25 isoform b

      Status: REVIEWED

      Source sequence(s)
      AL135838, AL845552
      Conserved Domains (2) summary
      sd00039
      Location:46 → 80
      7WD40; WD40 repeat [structural motif]
      cl29593
      Location:15 → 293
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    5. NM_001387351.1 → NP_001374280.1  WD repeat-containing protein 25 isoform b

      Status: REVIEWED

      Source sequence(s)
      AL135838, AL845552
      Related
      ENSP00000441903.2, ENST00000542471.2
      Conserved Domains (2) summary
      sd00039
      Location:46 → 80
      7WD40; WD40 repeat [structural motif]
      cl29593
      Location:15 → 293
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    6. NM_024515.6 → NP_078791.3  WD repeat-containing protein 25 isoform a

      See identical proteins and their annotated locations for NP_078791.3

      Status: REVIEWED

      Source sequence(s)
      AL135838, AL845552, AY295082, BG705426, HY044677
      Consensus CDS
      CCDS32157.1
      UniProtKB/Swiss-Prot
      A8K7E5, Q64LD2, Q6NVV6, Q86TQ4, Q9BTK5
      UniProtKB/TrEMBL
      A0A384NPW5
      Related
      ENSP00000334148.6, ENST00000335290.10
      Conserved Domains (2) summary
      sd00039
      Location:251 → 290
      7WD40; WD40 repeat [structural motif]
      cl29593
      Location:239 → 543
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000014.9 Reference GRCh38.p14 Primary Assembly

      Range
      100376485..100530303
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047431772.1 → XP_047287728.1  WD repeat-containing protein 25 isoform X1

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060938.1 Alternate T2T-CHM13v2.0

      Range
      94609583..94764104
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001350950.1: Suppressed sequence

      Description
      NM_001350950.1: This RefSeq was removed because currently there is support for the transcript but not for the protein.
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q64LD2.3 GenPept UniProtKB/Swiss-Prot:Q64LD2

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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