MOGAT2 monoacylglycerol O-acyltransferase 2 [Homo sapiens (human)] - Gene

Summary

Official Symbol: MOGAT2provided by HGNC
Official Full Name: monoacylglycerol O-acyltransferase 2provided by HGNC
Primary source: HGNC:HGNC:23248
See related: Ensembl:ENSG00000166391 MIM:610270; AllianceGenome:HGNC:23248
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: hDC5; MGAT2; DGAT2L5; DGAT2L5.
Summary: The protein encoded by this gene is an enzyme that catalyzes the synthesis of diacylglycerol from 2-monoacylglycerol and fatty acyl-CoA. The encoded protein is important in the uptake of dietary fat by the small intestine. This protein forms a complex with diacylglycerol O-acyltransferase 2 in the endoplasmic reticulum, and this complex catalyzes the synthesis of triacylglycerol. [provided by RefSeq, Dec 2015]
Annotation information: Note: MGAT2 (Gene ID: 4247) and MOGAT2 (Gene ID: 80168) share the MGAT2 symbol/alias in common. MGAT2 is a widely used alternative name for monoacylglycerol O-acyltransferase 2 (MOGAT2), which can be confused with the official symbol for MGAT2, mannosyl (alpha-1,6-)-glycoprotein beta-1,2-N-acetylglucosaminyltransferase. [25 Jun 2018]
Expression: Biased expression in small intestine (RPKM 52.4), duodenum (RPKM 48.1) and 2 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 11q13.5

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	11	NC_000011.10 (75717838..75732953)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	11	NC_060935.1 (75647254..75662376)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	11	NC_000011.9 (75428883..75443998)

Chromosome 11 - NC_000011.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

MGAT2 is a monoacylglycerol acyltransferase expressed in the small intestine
Title: MGAT2, a monoacylglycerol acyltransferase expressed in the small intestine.
MGAT2 functions as a dimeric or tetrameric protein and selectively heterodimerizes with DGAT1 in mammalian cells
Title: Monoacylglycerol acyltransferase-2 is a tetrameric enzyme that selectively heterodimerizes with diacylglycerol acyltransferase-1.
Mogat2(IKO) mice increased energy expenditure although to a lesser degree than Mogat2(-/-) mice and were protected against diet-induced weight gain and associated comorbidities
Title: Intestine-specific deletion of acyl-CoA:monoacylglycerol acyltransferase (MGAT) 2 protects mice from diet-induced obesity and glucose intolerance.
The described cell-based assay adds a new methodology for the development and evaluation of MGAT2 inhibitors for the treatment of obesity and type 2 diabetes
Title: Cell-based assay of MGAT2-driven diacylglycerol synthesis for profiling inhibitors: use of a stable isotope-labeled substrate and high-resolution LC/MS.
Diacylglycerol acyltransferase-2 and monoacylglycerol acyltransferase-2 are ubiquitinated proteins that are degraded by the 26S proteasome
Title: Diacylglycerol acyltransferase-2 and monoacylglycerol acyltransferase-2 are ubiquitinated proteins that are degraded by the 26S proteasome.
The use of 1-oleoyl-glycerol-d5 and (U13)C-TG oil followed by LC/ESI/MS/MS detection of stable-isotopic labeled DAG, TG, or glycerol provides a wide range of applications to study pathophysiological regulation of the monoacylglycerol pathway and MGAT2 activity.
Title: Metabolic tracing of monoacylglycerol acyltransferase-2 activity in vitro and in vivo.
MGAT2 in the intestine plays an indispensable role in enhancing metabolic efficiency but also raise the possibility that MGAT2 in other tissues may contribute to the regulation of energy metabolism.
Title: Intestine-specific expression of MOGAT2 partially restores metabolic efficiency in Mogat2-deficient mice.
MGAT2 may play an important role in dietary fat absorption
Title: Cloning and functional characterization of a mouse intestinal acyl-CoA:monoacylglycerol acyltransferase, MGAT2.

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Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Discovery and refinement of loci associated with lipid levels. EBI GWAS Catalog EBI GWAS CatalogPubMed
Genome-wide association study of plasma N6 polyunsaturated fatty acids within the cohorts for heart and aging research in genomic epidemiology consortium. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

NoName (e-PCR)
- UniSTS:484048

SHGC-32865 (e-PCR)
- UniSTS:56795

RH47251 (e-PCR)
- UniSTS:56796

FB16B8 (e-PCR)
- UniSTS:7678

Clone Names

FLJ22644, MGC119183, MGC119184, MGC119185

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables 2-acylglycerol O-acyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables 2-acylglycerol O-acyltransferase activity	IDA Inferred from Direct Assay more info	PubMed
enables 2-acylglycerol O-acyltransferase activity	TAS Traceable Author Statement more info
enables acetyltransferase activity	IEA Inferred from Electronic Annotation more info
enables diacylglycerol O-acyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in diacylglycerol biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in glycerol metabolic process	IEA Inferred from Electronic Annotation more info
involved_in intestinal absorption	IEA Inferred from Electronic Annotation more info
involved_in monoacylglycerol biosynthetic process	IDA Inferred from Direct Assay more info	PubMed
involved_in triglyceride biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in triglyceride biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in triglyceride biosynthetic process	TAS Traceable Author Statement more info

Component	Evidence Code	Pubs
located_in endoplasmic reticulum	IDA Inferred from Direct Assay more info	PubMed
is_active_in endoplasmic reticulum membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in endoplasmic reticulum membrane	TAS Traceable Author Statement more info
located_in perinuclear endoplasmic reticulum membrane	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: 2-acylglycerol O-acyltransferase 2

Names: acyl-CoA:monoacylglycerol acyltransferase 2; diacylglycerol O-acyltransferase candidate 5; diacylglycerol acyltransferase 2-like protein 5

NP_079374.2

EC 2.3.1.20

EC 2.3.1.22

XP_011543569.1

EC 2.3.1.20

EC 2.3.1.22

XP_024304464.1

EC 2.3.1.20

EC 2.3.1.22

XP_054226012.1

EC 2.3.1.20

EC 2.3.1.22

XP_054226013.1

EC 2.3.1.20

EC 2.3.1.22

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_025098.4 → NP_079374.2 2-acylglycerol O-acyltransferase 2

See identical proteins and their annotated locations for NP_079374.2

Status: REVIEWED

Source sequence(s)

AK000245, AK291998, DA922421

Consensus CDS

CCDS8240.1

UniProtKB/Swiss-Prot

A8K7I3, Q3SYC1, Q3SYC2, Q6ZQZ2, Q86UH6, Q9H630

Related

ENSP00000198801.5, ENST00000198801.10

Conserved Domains (1) summary

cl17185
Location:41 → 333

LPLAT; Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000011.10 Reference GRCh38.p14 Primary Assembly

Range

75717838..75732953

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_011545267.2 → XP_011543569.1 2-acylglycerol O-acyltransferase 2 isoform X1

Conserved Domains (1) summary

cl17185
Location:41 → 297

LPLAT; Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis
XM_024448696.2 → XP_024304464.1 2-acylglycerol O-acyltransferase 2 isoform X2

Conserved Domains (1) summary

cl17185
Location:3 → 215

LPLAT; Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis