Dcun1d1 defective in cullin neddylation 1 domain containing 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Dcun1d1provided by MGI
Official Full Name: defective in cullin neddylation 1 domain containing 1provided by MGI
Primary source: MGI:MGI:2150386
See related: Ensembl:ENSMUSG00000027708 AllianceGenome:MGI:2150386
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Rp42; Tes3; DCNL1; SCCRO; pTes3
Summary: Predicted to enable cullin family protein binding activity; ubiquitin conjugating enzyme binding activity; and ubiquitin-like protein binding activity. Predicted to be involved in positive regulation of protein neddylation; protein neddylation; and regulation of protein ubiquitination. Predicted to be located in cytosol and nucleoplasm. Predicted to be part of ubiquitin ligase complex. Is expressed in several structures, including central nervous system; genitourinary system; liver; lung; and spleen. Orthologous to human DCUN1D1 (defective in cullin neddylation 1 domain containing 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Broad expression in testis adult (RPKM 11.9), liver E14 (RPKM 6.9) and 21 other tissues See more
Orthologs: human all
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Genomic context

Location:: 3 B; 3 17.41 cM

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	3	NC_000069.7 (35946254..35991626, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	3	NC_000069.6 (35892105..35937472, complement)

Chromosome 3 - NC_000069.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

DCUN1D1, a new molecule involved in depigmentation via upregulating CXCL10.
Title: DCUN1D1, a new molecule involved in depigmentation via upregulating CXCL10.
Spermatozoa in DCUN1D1-/- mice had multiple abnormalities, including globozoospermia, macrocephaly, and multiple flagella.
Title: Mouse DCUN1D1 (SCCRO) is required for spermatogenetic individualization.
Data (including data from studies using cells cultured from knockout mice) suggest that Sccro neddylates Cul3 with Nedd8, promoting Cul3/Klhl21 complex formation and localization of Cul3 during telophase. (Sccro = squamous cell carcinoma-related oncogene; Cul3 = cullin 3; Nedd8 = neural precursor cell expressed, developmentally down-regulated protein 8; Klhl21 = kelch-like protein 21)
Title: Squamous cell carcinoma-related oncogene (SCCRO) neddylates Cul3 protein to selectively promote midbody localization and activity of Cul3(KLHL21) protein complex during abscission.
SCCRO family members cooperatively regulate neddylation and cell proliferation.
Title: Squamous Cell Carcinoma-related Oncogene (SCCRO) Family Members Regulate Cell Growth and Proliferation through Their Cooperative and Antagonistic Effects on Cullin Neddylation.
The ubiquitin-associated (UBA) domain of SCCRO/DCUN1D1 protein serves as a feedback regulator of biochemical and oncogenic activity.
Title: The ubiquitin-associated (UBA) domain of SCCRO/DCUN1D1 protein serves as a feedback regulator of biochemical and oncogenic activity.
in the nucleus, SCCRO enhances recruitment of Ubc12 to Cul1 to promote neddylation
Title: SCCRO (DCUN1D1) promotes nuclear translocation and assembly of the neddylation E3 complex.
SCCRO promotes glioma formation and malignant progression.
Title: SCCRO promotes glioma formation and malignant progression in mice.
SCCRO recruits Ubc12 approximately NEDD8 to the CAND1-Cul1-ROC1 complex but that this is not sufficient to dissociate or overcome the inhibitory effects of CAND1 on cullin neddylation
Title: SCCRO (DCUN1D1) is an essential component of the E3 complex for neddylation.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)
Gene trapped (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

C85469 (e-PCR)
- UniSTS:165248

24.MMHAP12FLH3.seq (e-PCR)
- UniSTS:159105

UniSTS:234659 (e-PCR)
- UniSTS:234659

Tes3-ps (e-PCR), detects polymorphism
- UniSTS:233945

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables cullin family protein binding	IBA Inferred from Biological aspect of Ancestor more info
enables cullin family protein binding	ISO Inferred from Sequence Orthology more info
enables cullin family protein binding	ISS Inferred from Sequence or Structural Similarity more info
enables ubiquitin conjugating enzyme binding	IBA Inferred from Biological aspect of Ancestor more info
enables ubiquitin-like protein binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in positive regulation of protein neddylation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein neddylation	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein neddylation	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of protein neddylation	ISO Inferred from Sequence Orthology more info
involved_in regulation of protein neddylation	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of protein ubiquitination	ISO Inferred from Sequence Orthology more info
involved_in regulation of protein ubiquitination	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info
part_of ubiquitin ligase complex	IBA Inferred from Biological aspect of Ancestor more info
part_of ubiquitin ligase complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: DCN1-like protein 1

Names: DCN1, defective in cullin neddylation 1, domain containing 1; DCUN1 domain-containing protein 1; defective in cullin neddylation protein 1-like protein 1; squamous cell carcinoma-related oncogene; testis derived transcript 3; testis-specific protein 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001205361.1 → NP_001192290.1 DCN1-like protein 1 isoform 1

See identical proteins and their annotated locations for NP_001192290.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (1).

Source sequence(s)

AC116677, AK008657

Consensus CDS

CCDS57207.1

UniProtKB/Swiss-Prot

Q3TMX2, Q8CDZ7, Q9QZ73

UniProtKB/TrEMBL

Q3TMV8

Related

ENSMUSP00000103817.6, ENSMUST00000108182.10

Conserved Domains (2) summary

cd14411
Location:1 → 51

UBA_DCNL1; UBA-like domain found in DCN1-like protein 1 (DCNL1) and similar proteins

pfam03556
Location:136 → 246

Cullin_binding; Cullin binding
NM_001205362.1 → NP_001192291.1 DCN1-like protein 1 isoform 2

See identical proteins and their annotated locations for NP_001192291.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region and uses a downstream, in-frame start codon, compared to variant 1. The encoded isoform (2) has a shorter N-terminus, compared to isoform 1. Variants 2 and 3 encode the same isoform (2).

Source sequence(s)

AC116677

Consensus CDS

CCDS17306.1

UniProtKB/TrEMBL

Q3TMV8, Q3UT23

Related

ENSMUSP00000137324.2, ENSMUST00000178098.8

Conserved Domains (2) summary

pfam03556
Location:121 → 231

Cullin_binding; Cullin binding

cl21463
Location:1 → 36

UBA_like_SF; UBA domain-like superfamily
NM_033623.6 → NP_296372.3 DCN1-like protein 1 isoform 2

See identical proteins and their annotated locations for NP_296372.3

Status: VALIDATED

Description

Transcript Variant: This variant (3) differs in the 5' UTR, lacks a portion of the 5' coding region and uses a downstream, in-frame start codon, compared to variant 1. The encoded isoform (2) has a shorter N-terminus, compared to isoform 1. Variants 2 and 3 encode the same isoform (2).

Source sequence(s)

AC116677, AK139845

Consensus CDS

CCDS17306.1

UniProtKB/TrEMBL

Q3TMV8, Q3UT23

Related

ENSMUSP00000143243.2, ENSMUST00000198389.5

Conserved Domains (2) summary

pfam03556
Location:121 → 231

Cullin_binding; Cullin binding

cl21463
Location:1 → 36

UBA_like_SF; UBA domain-like superfamily

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000069.7 Reference GRCm39 C57BL/6J

Range

35946254..35991626 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006535374.4 → XP_006535437.1 DCN1-like protein 1 isoform X1

See identical proteins and their annotated locations for XP_006535437.1

UniProtKB/TrEMBL

Q3TMV8, Q3UT23

Related

ENSMUSP00000115420.4, ENSMUST00000148465.8

Conserved Domains (2) summary

pfam03556
Location:121 → 231

Cullin_binding; Cullin binding

cl21463
Location:1 → 36

UBA_like_SF; UBA domain-like superfamily
XM_036162862.1 → XP_036018755.1 DCN1-like protein 1 isoform X2

Conserved Domains (2) summary

pfam03556
Location:136 → 173

Cullin_binding; Cullin binding

cl21463
Location:1 → 51

UBA_like_SF; UBA domain-like superfamily