Lgr4 leucine-rich repeat-containing G protein-coupled receptor 4 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Lgr4provided by MGI
Official Full Name: leucine-rich repeat-containing G protein-coupled receptor 4provided by MGI
Primary source: MGI:MGI:1891468
See related: Ensembl:ENSMUSG00000050199 AllianceGenome:MGI:1891468
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Gpr48; 9130225G07; A330106J01Rik; A930009A08Rik
Summary: Enables transmembrane signaling receptor activity. Involved in several processes, including metanephric nephron development; regulation of gene expression; and regulation of signal transduction. Acts upstream of or within several processes, including epithelial cell proliferation involved in renal tubule morphogenesis; intestinal stem cell homeostasis; and male genitalia development. Located in plasma membrane. Is expressed in several structures, including alimentary system; eye; integumental system; metanephros; and telencephalon. Used to study glaucoma. Orthologous to human LGR4 (leucine rich repeat containing G protein-coupled receptor 4). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in kidney adult (RPKM 25.0), colon adult (RPKM 21.8) and 25 other tissues See more
Orthologs: human all
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Genomic context

Location:: 2 E3; 2 56.65 cM

Exon count:: 18

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	2	NC_000068.8 (109747919..109844602)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	2	NC_000068.7 (109917647..110014257)

Chromosome 2 - NC_000068.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

LGR signaling mediates muscle-adipose tissue crosstalk and protects against diet-induced insulin resistance.
Title: LGR signaling mediates muscle-adipose tissue crosstalk and protects against diet-induced insulin resistance.
Endothelial RSPO3 mediates pulmonary endothelial regeneration by LGR4-dependent activation of beta-catenin and ILK signaling pathways after inflammatory vascular injury.
Title: Endothelial RSPO3 mediates pulmonary endothelial regeneration by LGR4-dependent activation of β-catenin and ILK signaling pathways after inflammatory vascular injury.
Reduction of specific enterocytes from loss of intestinal LGR4 improves lipid metabolism in mice.
Title: Reduction of specific enterocytes from loss of intestinal LGR4 improves lipid metabolism in mice.
Hepatic LGR4 aggravates cholestasis-induced liver injury in mice.
Title: Hepatic LGR4 aggravates cholestasis-induced liver injury in mice.
Rspo2-LGR4 exacerbates hepatocellular carcinoma progression via activation of Wnt/beta-catenin signaling pathway.
Title: Rspo2-LGR4 exacerbates hepatocellular carcinoma progression via activation of Wnt/β-catenin signaling pathway.
R-spondin 3/LGR4 (Leucine-Rich Repeat-Containing G Protein-Coupled Receptor 4) Axis Is a Novel Inflammatory and Neurite Outgrowth Signaling System in the Ischemic Brain in Mice.
Title: R-spondin 3/LGR4 (Leucine-Rich Repeat-Containing G Protein-Coupled Receptor 4) Axis Is a Novel Inflammatory and Neurite Outgrowth Signaling System in the Ischemic Brain in Mice.
Loss of LGR4/GPR48 causes severe neonatal salt wasting due to disrupted WNT signaling altering adrenal zonation.
Title: Loss of LGR4/GPR48 causes severe neonatal salt wasting due to disrupted WNT signaling altering adrenal zonation.
SOX2 suppresses osteoblast differentiation of MC3T3-E1 cells through activating the transcription of LGR4.
Title: SOX2 suppresses osteoblast differentiation of MC3T3-E1 cells through activating the transcription of LGR4.
Loss of Hepatic Leucine-Rich Repeat-Containing G-Protein Coupled Receptors 4 and 5 Promotes Nonalcoholic Fatty Liver Disease.
Title: Loss of Hepatic Leucine-Rich Repeat-Containing G-Protein Coupled Receptors 4 and 5 Promotes Nonalcoholic Fatty Liver Disease.
Lgr4 promotes aerobic glycolysis and differentiation in osteoblasts via the canonical Wnt/beta-catenin pathway.
Title: Lgr4 promotes aerobic glycolysis and differentiation in osteoblasts via the canonical Wnt/β-catenin pathway.

Submit: New GeneRIF Correction See all GeneRIFs (69)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (4) 1 citation
Gene trapped (4) 1 citation
Targeted (8) 1 citation

General gene information

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Markers

01.MMHAP6FLA1.seq (e-PCR)
- UniSTS:122669

D2Jcs2 (e-PCR), detects polymorphism
- UniSTS:472889

D2Mit480 (e-PCR), detects polymorphism
- UniSTS:129397

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
NOT enables G protein-coupled receptor activity	IDA Inferred from Direct Assay more info	PubMed
enables Roundabout binding	IBA Inferred from Biological aspect of Ancestor more info
enables heparin binding	IBA Inferred from Biological aspect of Ancestor more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein-hormone receptor activity	IEA Inferred from Electronic Annotation more info
enables transmembrane signaling receptor activity	IDA Inferred from Direct Assay more info	PubMed
enables transmembrane signaling receptor activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in G protein-coupled receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in Wnt signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in axon guidance	IBA Inferred from Biological aspect of Ancestor more info
involved_in bone mineralization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in bone remodeling	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in circadian regulation of gene expression	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in circadian rhythm	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within digestive tract development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within epithelial cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within epithelial cell proliferation involved in renal tubule morphogenesis	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within hair follicle development	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within hair follicle development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in innate immune response	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within intestinal stem cell homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within male genitalia development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in metanephric glomerulus development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in metanephric nephron tubule morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative chemotaxis	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of cold-induced thermogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of cytokine production	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of toll-like receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in osteoblast differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of branching involved in ureteric bud morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of canonical Wnt signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of canonical Wnt signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of canonical Wnt signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in spermatogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within tube morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: leucine-rich repeat-containing G-protein coupled receptor 4

Names: G protein-coupled receptor GPR48; G-protein coupled receptor 48

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_172671.2 → NP_766259.2 leucine-rich repeat-containing G-protein coupled receptor 4 precursor

See identical proteins and their annotated locations for NP_766259.2

Status: VALIDATED

Source sequence(s)

AK033699, BE861913, BE987673, BU520309, CA527305, CF164628, CJ093786, CN456468, CN667965

Consensus CDS

CCDS38195.1

UniProtKB/Swiss-Prot

A2ARI3, A2ARI4, Q6PHA3, Q80T31, Q8BXS9

Related

ENSMUSP00000047325.8, ENSMUST00000046548.14

Conserved Domains (6) summary

smart00370
Location:388 → 410

LRR; Leucine-rich repeats, outliers

smart00013
Location:29 → 61

LRRNT; Leucine rich repeat N-terminal domain

cd00116
Location:83 → 375

LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...

sd00033
Location:59 → 82

LRR_RI; leucine-rich repeat [structural motif]

pfam00001
Location:556 → 801

7tm_1; 7 transmembrane receptor (rhodopsin family)

pfam13855
Location:177 → 237

LRR_8; Leucine rich repeat

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000068.8 Reference GRCm39 C57BL/6J

Range

109747919..109844602

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036157249.1 → XP_036013142.1 leucine-rich repeat-containing G-protein coupled receptor 4 isoform X1

Conserved Domains (4) summary

smart00013
Location:29 → 61

LRRNT; Leucine rich repeat N-terminal domain

sd00033
Location:59 → 82

LRR_RI; leucine-rich repeat [structural motif]

cd15361
Location:515 → 788

7tmA_LGR4; leucine-rich repeats-containing G protein-coupled receptor 4, member of the class A family of seven-transmembrane G protein-coupled receptors

NF033189
Location:89 → 439

internalin_A; class 1 internalin InlA