Cdkn3 cyclin dependent kinase inhibitor 3 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Cdkn3provided by MGI
Official Full Name: cyclin dependent kinase inhibitor 3provided by MGI
Primary source: MGI:MGI:1919641
See related: Ensembl:ENSMUSG00000037628 AllianceGenome:MGI:1919641
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: KAP; 2410006H10Rik
Summary: Predicted to enable protein serine/threonine phosphatase activity and protein tyrosine phosphatase activity. Predicted to be involved in protein dephosphorylation. Predicted to act upstream of or within DNA damage response and regulation of cell cycle. Predicted to be located in cytosol and perinuclear region of cytoplasm. Predicted to be active in cytoplasm and nucleus. Is expressed in axial skeleton; cerebral cortex; cranium; hindlimb long bone; and pelvic girdle skeleton. Human ortholog(s) of this gene implicated in hepatocellular carcinoma. Orthologous to human CDKN3 (cyclin dependent kinase inhibitor 3). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in testis adult (RPKM 55.4), liver E14 (RPKM 19.2) and 6 other tissues See more
Orthologs: human all
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Genomic context

Location:: 14 24.28 cM; 14 C1

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	14	NC_000080.7 (46997912..47008987)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	14	NC_000080.6 (46760461..46771530)

Chromosome 14 - NC_000080.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

NEAT1 may exert a protective effect on HUVECs by regulating the miR-181d-5p/CDKN3A axis
Title: Long non-coding RNA NEAT1 inhibits oxidative stress-induced vascular endothelial cell injury by activating the miR-181d-5p/CDKN3 axis.
Knockdown of CDKN3 expression inhibited prostate cancer tumor growth in the nude mouse model.
Title: Cyclin-dependent kinase inhibitor 3 (CDKN3) plays a critical role in prostate cancer via regulating cell cycle and DNA replication signaling.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3)

General gene information

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Markers

D14Mit141 (e-PCR), detects polymorphism
- UniSTS:127248

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables MAP kinase serine/threonine phosphatase activity	IEA Inferred from Electronic Annotation more info
enables RNA polymerase II CTD heptapeptide repeat S2 phosphatase activity	IEA Inferred from Electronic Annotation more info
enables RNA polymerase II CTD heptapeptide repeat S5 phosphatase activity	IEA Inferred from Electronic Annotation more info
enables RNA polymerase II CTD heptapeptide repeat S7 phosphatase activity	IEA Inferred from Electronic Annotation more info
enables RNA polymerase II CTD heptapeptide repeat T4 phosphatase activity	IEA Inferred from Electronic Annotation more info
enables RNA polymerase II CTD heptapeptide repeat Y1 phosphatase activity	IEA Inferred from Electronic Annotation more info
enables calmodulin-dependent protein phosphatase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AXS140 phosphatase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AXY142 phosphatase activity	IEA Inferred from Electronic Annotation more info
enables myosin phosphatase activity	IEA Inferred from Electronic Annotation more info
enables non-membrane spanning protein tyrosine phosphatase activity	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein serine/threonine phosphatase activity	ISO Inferred from Sequence Orthology more info
enables protein tyrosine phosphatase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein tyrosine phosphatase activity	ISO Inferred from Sequence Orthology more info
enables protein tyrosine phosphatase activity, metal-dependent	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within DNA damage response	ISO Inferred from Sequence Orthology more info	PubMed
involved_in chromatin remodeling	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of cell cycle	ISO Inferred from Sequence Orthology more info
involved_in regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in perinuclear region of cytoplasm	ISO Inferred from Sequence Orthology more info
located_in perinuclear region of cytoplasm	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: cyclin-dependent kinase inhibitor 3

Names: CDK2-associated dual-specificity phosphatase; kinase-associated phosphatase

NP_001346970.1

EC 3.1.3.16

EC 3.1.3.48

NP_082498.1

EC 3.1.3.16

EC 3.1.3.48

XP_006519656.1

EC 3.1.3.16

EC 3.1.3.48

XP_006519657.1

EC 3.1.3.16

EC 3.1.3.48

XP_030103904.1

EC 3.1.3.16

EC 3.1.3.48

XP_036014748.1

EC 3.1.3.16

EC 3.1.3.48

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001360041.1 → NP_001346970.1 cyclin-dependent kinase inhibitor 3 isoform 1

Status: VALIDATED

Source sequence(s)

AA218046, AA510251, BY084534

Related

ENSMUST00000226621.2

Conserved Domains (1) summary

pfam05706
Location:1 → 168

CDKN3; Cyclin-dependent kinase inhibitor 3 (CDKN3)
NM_028222.2 → NP_082498.1 cyclin-dependent kinase inhibitor 3 isoform 2

See identical proteins and their annotated locations for NP_082498.1

Status: VALIDATED

Source sequence(s)

AA218046, BC049694, BY084534

Consensus CDS

CCDS49466.1

UniProtKB/Swiss-Prot

Q810P3, Q9CWS3

Related

ENSMUSP00000070575.5, ENSMUST00000067426.6

Conserved Domains (1) summary

pfam05706
Location:1 → 167

CDKN3; Cyclin-dependent kinase inhibitor 3 (CDKN3)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000080.7 Reference GRCm39 C57BL/6J

Range

46997912..47008987

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036158855.1 → XP_036014748.1 cyclin-dependent kinase inhibitor 3 isoform X1

UniProtKB/TrEMBL

A0A2I3BPS7

Related

ENSMUSP00000154120.2, ENSMUST00000228106.2

Conserved Domains (1) summary

cl28904
Location:1 → 139

PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily
XM_030248044.1 → XP_030103904.1 cyclin-dependent kinase inhibitor 3 isoform X3

Conserved Domains (1) summary

cl28904
Location:17 → 153

PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily
XM_006519594.4 → XP_006519657.1 cyclin-dependent kinase inhibitor 3 isoform X2

See identical proteins and their annotated locations for XP_006519657.1

Conserved Domains (1) summary

cl28904
Location:17 → 154

PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily
XM_006519593.3 → XP_006519656.1 cyclin-dependent kinase inhibitor 3 isoform X2

See identical proteins and their annotated locations for XP_006519656.1

Conserved Domains (1) summary

cl28904
Location:17 → 154

PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily