IFITM1 interferon induced transmembrane protein 1 [Homo sapiens (human)] - Gene

Summary

Official Symbol: IFITM1provided by HGNC
Official Full Name: interferon induced transmembrane protein 1provided by HGNC
Primary source: HGNC:HGNC:5412
See related: Ensembl:ENSG00000185885 MIM:604456; AllianceGenome:HGNC:5412
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: 9-27; CD225; IFI17; LEU13; DSPA2a
Summary: Interferon-induced transmembrane (IFITM) proteins are a family of interferon induced antiviral proteins. The family contains five members, including IFITM1, IFITM2 and IFITM3 that belong to the CD225 superfamily. The protein encoded by this gene restricts cellular entry by diverse viral pathogens, such as influenza A virus, Ebola virus and Sars-CoV-2. [provided by RefSeq, Nov 2021]
Annotation information: Note: This gene has been reviewed for its involvement in coronavirus biology, and is involved in immune response or antiviral activity.
Expression: Ubiquitous expression in spleen (RPKM 191.9), endometrium (RPKM 153.8) and 24 other tissues See more
Orthologs: all
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Genomic context

Location:: 11p15.5

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	11	NC_000011.10 (314040..315272)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	11	NC_060935.1 (355743..359591, complement)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	11	NC_000011.9 (314040..315272)

Chromosome 11 - NC_000011.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

IFITM1 and IFITM3 Proteins Inhibit the Infectivity of Progeny HIV-1 without Disrupting Envelope Glycoprotein Clusters.
Title: IFITM1 and IFITM3 Proteins Inhibit the Infectivity of Progeny HIV-1 without Disrupting Envelope Glycoprotein Clusters.
Genome-wide DNA methylation analysis implicates enrichment of interferon pathway in African American patients with Systemic Lupus Erythematosus and European Americans with lupus nephritis.
Title: Genome-wide DNA methylation analysis implicates enrichment of interferon pathway in African American patients with Systemic Lupus Erythematosus and European Americans with lupus nephritis.
Toll-like receptor 3 signaling induces interferon-induced transmembrane protein 1 in BEAS-2B cells.
Title: Toll-like receptor 3 signaling induces interferon-induced transmembrane protein 1 in BEAS-2B cells.
Co-expression of DDR2 and IFITM1 promotes breast cancer cell proliferation, migration and invasion and inhibits apoptosis.
Title: Co-expression of DDR2 and IFITM1 promotes breast cancer cell proliferation, migration and invasion and inhibits apoptosis.
MiR-504-3p Has Tumor-Suppressing Activity and Decreases IFITM1 Expression in Non-Small Cell Lung Cancer Cells.
Title: MiR-504-3p Has Tumor-Suppressing Activity and Decreases IFITM1 Expression in Non-Small Cell Lung Cancer Cells.
Emergent Role of IFITM1/3 towards Splicing Factor (SRSF1) and Antigen-Presenting Molecule (HLA-B) in Cervical Cancer.
Title: Emergent Role of IFITM1/3 towards Splicing Factor (SRSF1) and Antigen-Presenting Molecule (HLA-B) in Cervical Cancer.
Differential Leukocyte Expression of IFITM1 and IFITM3 in Patients with Severe Pandemic Influenza A(H1N1) and COVID-19.
Title: Differential Leukocyte Expression of IFITM1 and IFITM3 in Patients with Severe Pandemic Influenza A(H1N1) and COVID-19.
Interferon-Induced Transmembrane Proteins Inhibit Infection by the Kaposi's Sarcoma-Associated Herpesvirus and the Related Rhesus Monkey Rhadinovirus in a Cell-Specific Manner.
Title: Interferon-Induced Transmembrane Proteins Inhibit Infection by the Kaposi's Sarcoma-Associated Herpesvirus and the Related Rhesus Monkey Rhadinovirus in a Cell-Specific Manner.
Disrupting interferon-alpha and NF-kappaB crosstalk suppresses IFITM1 expression attenuating triple-negative breast cancer progression.
Title: Disrupting interferon-alpha and NF-kappaB crosstalk suppresses IFITM1 expression attenuating triple-negative breast cancer progression.
IFITM1 expression determines extracellular vesicle uptake in colorectal cancer.
Title: IFITM1 expression determines extracellular vesicle uptake in colorectal cancer.

Submit: New GeneRIF Correction See all GeneRIFs (80)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Replication interactions

Interaction	Pubs
HIV-1 incorporates IFITM1 into virions but this incorporation does not strictly correlate with the phenotype of IFITM inhibition of HIV-1 cell-to-cell infection	PubMed
Knockdown of IFITM1/2/3 by siRNA enhances virus transmission to target cells and the production of virions in CD4+ T cells	PubMed
HIV-1 cell-to-cell transmission (Jurkat-to-Jurkat and PBMCs-to-Jurkat) is inhibited by IFITM1	PubMed
HIV-1 cell-to-cell transmission (Jurkat-to-Jurkat) is inhibited by IFITM1 and this inhibition appears to be regulated by the IFITM protein C terminus, is IFITM-species specific and virus-strain specific	PubMed

Protein interactions

Protein	Gene	Interaction	Pubs
Envelope surface glycoprotein gp120	env	HIV-1 gp120 interacts with IFITM1	PubMed
Envelope surface glycoprotein gp160, precursor	env	Replacement of the Env of HIV-1 BH10 with the counterpart of HIV-1 NL4-3 enables HIV-1 BH10 to replicate in IFITM1-expressing cells, whereas inserting the Env of HIV-1 BH10 into HIV-1 NL4-3 reduces virus replication in the presence of IFITM1	PubMed
	env	HIV-1 NL4-3 Env inhibits IFITM1-mediated restriction of HIV-1 replication by enhancing HIV-1 cell-to-cell transmission	PubMed
	env	Vpu34 (a stop-codon at position 35) and EnvG367E mutations rescue HIV-1 replication in IFITM1-expressing SupT1 cells by enhancing HIV-1 cell-to-cell transmission	PubMed
Envelope transmembrane glycoprotein gp41	env	HIV-1 gp41 interacts with IFITM1	PubMed
Nef	nef	IFITM1 significantly downregulates the expression of HIV-1 Nef by interfering with Tat/TAR-mediated expression	PubMed
Pr55(Gag)	gag	IFITM1, IFITM2, and IFITM3 proteins (IFITMs) co-localize with HIV-1 Gag in virus-producing cells and co-assemble with Gag into budding particles	PubMed
	gag	Endogenous IFITM1/2/3 proteins are upregulated in activated CD4+ T cells and incorporated into HIV-1 Gag/p24-associated virions during infection	PubMed
	gag	IFITM1 significantly downregulates the expression of HIV-1 Gag and CA by interfering with both Rev/RRE- and Tat/TAR-mediated expression	PubMed
Tat	tat	HIV-1 Tat upregulates the expression of interferon induced transmembrane protein 1 (IFITM1) in human primary T cells	PubMed
Vif	vif	IFITM1 significantly downregulates the expression of HIV-1 Vif by interfering with both Rev/RRE- and Tat/TAR-mediated expression	PubMed
Vpr	vpr	HIV-1 gp160 interacts with IFITM1	PubMed
	vpr	HIV-1 Vpr upregulates the expression of IFITM1 in human monocyte-derived dendritic cells	PubMed
	vpr	IFITM1, 2 or 3 marginally inhibit the entry of HIV-1 NL4-3 and SIV Mac into TZM-bl by measuring the cleavage of CCF2 by BlaM-Vpr that enters the cytoplasm together with viral cores	PubMed
Vpu	vpu	Vpu34 (a stop-codon at position 35) and EnvG367E mutations rescue HIV-1 replication in IFITM1-expressing SupT1 cells by enhancing HIV-1 cell-to-cell transmission	PubMed
capsid	gag	IFITM1, IFITM2, and IFITM3 proteins (IFITMs) co-localize with HIV-1 CA in velocity gradients, indicating that IFITMs are virion-associated proteins	PubMed
	gag	Endogenous IFITM1/2/3 proteins are upregulated in activated CD4+ T cells and incorporated into HIV-1 Gag/p24-associated virions during infection	PubMed
	gag	Depletion of IFITM1 expression upregulates HIV-1 CA A92E mutant infectivity in CsA-untreated HeLa cells and downregulates its infectivity in CsA-treated HeLa cells	PubMed
	gag	IFITM1 significantly downregulates the expression of HIV-1 Gag and CA by interfering with both Rev/RRE- and Tat/TAR-mediated expression	PubMed

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH36343 (e-PCR)
- UniSTS:49426

PMC299790P3 (e-PCR)
- UniSTS:272463

PMC299790P4 (e-PCR)
- UniSTS:272464

PMC154027P3 (e-PCR)
- UniSTS:271286

A004R14 (e-PCR)
- UniSTS:56542

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in cell surface receptor signaling pathway	TAS Traceable Author Statement more info	PubMed
involved_in defense response to virus	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of cell population proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of viral entry into host cell	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of viral entry into host cell	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of viral genome replication	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of viral genome replication	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of viral genome replication	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in ossification	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of osteoblast differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to interferon-alpha	IBA Inferred from Biological aspect of Ancestor more info
involved_in response to interferon-alpha	IDA Inferred from Direct Assay more info	PubMed
involved_in response to interferon-beta	IBA Inferred from Biological aspect of Ancestor more info
involved_in response to interferon-beta	IDA Inferred from Direct Assay more info	PubMed
involved_in response to type II interferon	IBA Inferred from Biological aspect of Ancestor more info
involved_in response to type II interferon	IDA Inferred from Direct Assay more info	PubMed
involved_in response to virus	IDA Inferred from Direct Assay more info	PubMed
involved_in type I interferon-mediated signaling pathway	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in lysosomal membrane	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	HDA more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	TAS Traceable Author Statement more info
part_of protein-containing complex	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: interferon-induced transmembrane protein 1

Names: dispanin subfamily A member 2a; interferon-induced protein 17; interferon-inducible protein 9-27; leu-13 antigen

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_003641.5 → NP_003632.4 interferon-induced transmembrane protein 1

Status: REVIEWED

Source sequence(s)

AC136475

Consensus CDS

CCDS41584.1

UniProtKB/Swiss-Prot

P13164, Q15322, Q53XZ0

UniProtKB/TrEMBL

A0A7P0T8E0

Related

ENSP00000386187.3, ENST00000408968.4

Conserved Domains (1) summary

pfam04505
Location:34 → 98

CD225; Interferon-induced transmembrane protein