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    Mcc mutated in colorectal cancers [ Mus musculus (house mouse) ]

    Gene ID: 328949, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Mccprovided by MGI
    Official Full Name
    mutated in colorectal cancersprovided by MGI
    Primary source
    MGI:MGI:96930
    See related
    Ensembl:ENSMUSG00000071856 AllianceGenome:MGI:96930
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    E330037C19; D18Ertd451e
    Summary
    Predicted to be involved in several processes, including negative regulation of canonical Wnt signaling pathway; negative regulation of epithelial cell migration; and negative regulation of epithelial cell proliferation. Predicted to be located in cytosol; nucleoplasm; and plasma membrane. Predicted to be active in cytoplasm. Is expressed in several structures, including embryo mesenchyme; gut; nervous system; primitive streak; and sensory organ. Human ortholog(s) of this gene implicated in colorectal cancer. Orthologous to human MCC (MCC regulator of WNT signaling pathway). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in lung adult (RPKM 10.4), cerebellum adult (RPKM 5.0) and 24 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Mcc in Genome Data Viewer
    Location:
    18 B3; 18 23.74 cM
    Exon count:
    25
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 18 NC_000084.7 (44558127..44945573, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 18 NC_000084.6 (44425060..44812182, complement)

    Chromosome 18 - NC_000084.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_44459 Neighboring gene STARR-seq mESC enhancer starr_44461 Neighboring gene STARR-positive B cell enhancer ABC_E9976 Neighboring gene myotilin Neighboring gene decapping mRNA 2 Neighboring gene STARR-seq mESC enhancer starr_44470 Neighboring gene predicted gene, 52347 Neighboring gene STARR-seq mESC enhancer starr_44475 Neighboring gene STARR-seq mESC enhancer starr_44477 Neighboring gene RIKEN cDNA A930012L18 gene Neighboring gene STARR-seq mESC enhancer starr_44478 Neighboring gene STARR-seq mESC enhancer starr_44479 Neighboring gene STARR-seq mESC enhancer starr_44481 Neighboring gene YTH domain containing 2 Neighboring gene STARR-seq mESC enhancer starr_44482 Neighboring gene STARR-seq mESC enhancer starr_44483 Neighboring gene STARR-seq mESC enhancer starr_44484 Neighboring gene STARR-seq mESC enhancer starr_44486 Neighboring gene predicted gene, 31706 Neighboring gene mortality factor 4 like 1 pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Mouse Model of Mutated in Colorectal Cancer Gene Deletion Reveals Novel Pathways in Inflammation and Cancer. Currey N, et al. Cell Mol Gastroenterol Hepatol, 2019. PMID 30831321, Free PMC Article
    2. Mutated in colorectal cancer (Mcc), a candidate tumor suppressor, is dynamically expressed during mouse embryogenesis. Young T, et al. Dev Dyn, 2011 Sep. PMID 22016184
    3. Mutated in colorectal cancer (MCC) is a novel oncogene in B lymphocytes. Edwards SK, et al. J Hematol Oncol, 2014 Sep 9. PMID 25200342, Free PMC Article
    4. Identification of a gene located at chromosome 5q21 that is mutated in colorectal cancers. Kinzler KW, et al. Science, 1991 Mar 15. PMID 1848370
    5. Mapping of multiple intestinal neoplasia (Min) to proximal chromosome 18 of the mouse. Luongo C, et al. Genomics, 1993 Jan. PMID 8094372

    See all (28) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Loss of Mcc may promote cancer through a failure to repair inflammation-induced DNA damage.
      Title: Mouse Model of Mutated in Colorectal Cancer Gene Deletion Reveals Novel Pathways in Inflammation and Cancer.
    2. Our results indicate that in sharp contrast to its tumor suppressive role in colorectal cancer, MCC functions as an oncogene in B cells
      Title: Mutated in colorectal cancer (MCC) is a novel oncogene in B lymphocytes.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Gene trapped (3) 
    • Targeted (3)  1 citation

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Process Evidence Code Pubs
    involved_in establishment of protein localization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of canonical Wnt signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of canonical Wnt signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of epithelial cell migration ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of epithelial cell proliferation ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    colorectal mutant cancer protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001085373.1 → NP_001078842.1  colorectal mutant cancer protein isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (1).
      Source sequence(s)
      AC137150, AC147551, AK054528, AK158266, BU756994
      Consensus CDS
      CCDS50277.1
      UniProtKB/TrEMBL
      E9PWI3, Q3TYX4
      Related
      ENSMUSP00000087318.6, ENSMUST00000089874.9
      Conserved Domains (4) summary
      cd00051
      Location:24 → 80
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
      pfam10506
      Location:577 → 640
      MCC-bdg_PDZ; PDZ domain of MCC-2 bdg protein for Usher syndrome
      pfam13499
      Location:25 → 78
      EF-hand_7; EF-hand domain pair
      pfam16046
      Location:146 → 271
      FAM76; FAM76 protein

    2. NM_001085374.1 → NP_001078843.1  colorectal mutant cancer protein isoform 2

      See identical proteins and their annotated locations for NP_001078843.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks a portion of the 5' coding region, and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (2) has a distinct N-terminus and is shorter than isoform 1.
      Source sequence(s)
      AC147551, AK054528, BU756994
      Consensus CDS
      CCDS50276.1
      UniProtKB/TrEMBL
      G3UW40, Q3TYX4
      Related
      ENSMUSP00000128032.2, ENSMUST00000164666.6
      Conserved Domains (2) summary
      pfam10506
      Location:402 → 465
      MCC-bdg_PDZ; PDZ domain of MCC-2 bdg protein for Usher syndrome
      cl23720
      Location:13 → 134
      RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000084.7 Reference GRCm39 C57BL/6J

      Range
      44558127..44945573 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036161179.1 → XP_036017072.1  colorectal mutant cancer protein isoform X1

      UniProtKB/TrEMBL
      Q3TYX4
      Conserved Domains (2) summary
      COG1196
      Location:615 → 877
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam10506
      Location:459 → 523
      MCC-bdg_PDZ; PDZ domain of MCC-2 bdg protein for Usher syndrome

    2. XM_006526024.4 → XP_006526087.1  colorectal mutant cancer protein isoform X3

      See identical proteins and their annotated locations for XP_006526087.1

      Conserved Domains (2) summary
      COG1196
      Location:495 → 757
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam10506
      Location:339 → 403
      MCC-bdg_PDZ; PDZ domain of MCC-2 bdg protein for Usher syndrome

    3. XM_030250510.2 → XP_030106370.1  colorectal mutant cancer protein isoform X3

      Conserved Domains (2) summary
      COG1196
      Location:495 → 757
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam10506
      Location:339 → 403
      MCC-bdg_PDZ; PDZ domain of MCC-2 bdg protein for Usher syndrome

    4. XM_006526026.5 → XP_006526089.1  colorectal mutant cancer protein isoform X3

      See identical proteins and their annotated locations for XP_006526089.1

      Conserved Domains (2) summary
      COG1196
      Location:495 → 757
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam10506
      Location:339 → 403
      MCC-bdg_PDZ; PDZ domain of MCC-2 bdg protein for Usher syndrome

    5. XM_006526025.5 → XP_006526088.1  colorectal mutant cancer protein isoform X3

      See identical proteins and their annotated locations for XP_006526088.1

      Conserved Domains (2) summary
      COG1196
      Location:495 → 757
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam10506
      Location:339 → 403
      MCC-bdg_PDZ; PDZ domain of MCC-2 bdg protein for Usher syndrome

    6. XM_036161181.1 → XP_036017074.1  colorectal mutant cancer protein isoform X3

      Conserved Domains (2) summary
      COG1196
      Location:495 → 757
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam10506
      Location:339 → 403
      MCC-bdg_PDZ; PDZ domain of MCC-2 bdg protein for Usher syndrome

    7. XM_006526023.5 → XP_006526086.1  colorectal mutant cancer protein isoform X2

      UniProtKB/TrEMBL
      Q3TYX4
      Conserved Domains (3) summary
      COG1196
      Location:587 → 849
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      TIGR02169
      Location:36 → 323
      SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type
      pfam10506
      Location:431 → 494
      MCC-bdg_PDZ; PDZ domain of MCC-2 bdg protein for Usher syndrome

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001033406.1: Suppressed sequence

      Description
      NM_001033406.1: This RefSeq was permanently suppressed because it is primarily UTR sequence.
    Nucleotide Protein Strain
    Heading Accession and Version

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