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    MAP3K6 mitogen-activated protein kinase kinase kinase 6 [ Homo sapiens (human) ]

    Gene ID: 9064, updated on 2-Nov-2024

    Summary

    Official Symbol
    MAP3K6provided by HGNC
    Official Full Name
    mitogen-activated protein kinase kinase kinase 6provided by HGNC
    Primary source
    HGNC:HGNC:6858
    See related
    Ensembl:ENSG00000142733 MIM:604468; AllianceGenome:HGNC:6858
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    ASK2; MEKK6; MAPKKK6
    Summary
    This gene encodes a serine/threonine protein kinase that forms a component of protein kinase-mediated signal transduction cascades. The encoded kinase participates in the regulation of vascular endothelial growth factor (VEGF) expression. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]
    Expression
    Broad expression in skin (RPKM 18.7), fat (RPKM 11.6) and 21 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See MAP3K6 in Genome Data Viewer
    Location:
    1p36.11
    Exon count:
    30
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (27355184..27366961, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (27196422..27208199, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (27681675..27693452, complement)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene transmembrane protein 222 Neighboring gene actin gamma 1 pseudogene 20 Neighboring gene RNA, U6 small nuclear 48, pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid active region 543 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 544 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:27669148-27669765 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 545 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:27673548-27674088 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:27674089-27674627 Neighboring gene synaptotagmin like 1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 508 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 509 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:27685945-27686480 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:27686481-27687016 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 546 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 510 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 511 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:27692433-27693376 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:27693377-27694318 Neighboring gene ficolin 3 Neighboring gene CD164 molecule like 2

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • MGC20114, MGC125653

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables ATP binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables MAP kinase kinase kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables MAP kinase kinase kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables magnesium ion binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein serine kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in JNK cascade IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in MAPK cascade IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in p38MAPK cascade IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in protein phosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in signal transduction TAS
    Traceable Author Statement
    more info
    PubMed 

    General protein information

    Preferred Names
    mitogen-activated protein kinase kinase kinase 6
    Names
    apoptosis signal-regulating kinase 2
    NP_001284538.1
    NP_004663.3
    XP_016858261.1
    XP_047289645.1
    XP_047289648.1
    XP_047289651.1
    XP_054195489.1
    XP_054195490.1
    XP_054195491.1
    XP_054195492.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_051309.1 RefSeqGene

      Range
      6077..17854
      Download
      GenBank, FASTA, Sequence Viewer (Graphics), LRG_1086

    mRNA and Protein(s)

    1. NM_001297609.2NP_001284538.1  mitogen-activated protein kinase kinase kinase 6 isoform 2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 5' coding region, compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
      Source sequence(s)
      AB208805, AI658745, AW771625, FO393419
      Consensus CDS
      CCDS72738.1
      UniProtKB/Swiss-Prot
      O95382
      Related
      ENSP00000363152.2, ENST00000374040.7
      Conserved Domains (3) summary
      smart00220
      Location:645898
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd06624
      Location:631898
      STKc_ASK; Catalytic domain of the Serine/Threonine Kinase, Apoptosis signal-regulating kinase
      pfam13281
      Location:129498
      DUF4071; Domain of unknown function (DUF4071)
    2. NM_004672.5NP_004663.3  mitogen-activated protein kinase kinase kinase 6 isoform 1

      See identical proteins and their annotated locations for NP_004663.3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AB167411, AF100318, AW771625, FO393419
      Consensus CDS
      CCDS299.1
      UniProtKB/Swiss-Prot
      A2ACE8, A2VDG4, A2VDG5, O95382, Q59HF4, Q5SSD4, Q75PK3, Q96B75
      Related
      ENSP00000350195.2, ENST00000357582.3
      Conserved Domains (3) summary
      smart00220
      Location:653906
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd06624
      Location:639906
      STKc_ASK; Catalytic domain of the Serine/Threonine Kinase, Apoptosis signal-regulating kinase
      pfam13281
      Location:129506
      DUF4071; Domain of unknown function (DUF4071)

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

      Range
      27355184..27366961 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047433689.1XP_047289645.1  mitogen-activated protein kinase kinase kinase 6 isoform X1

      Related
      ENST00000493901.6
    2. XM_047433695.1XP_047289651.1  mitogen-activated protein kinase kinase kinase 6 isoform X3

    3. XM_047433692.1XP_047289648.1  mitogen-activated protein kinase kinase kinase 6 isoform X2

    4. XM_017002772.2XP_016858261.1  mitogen-activated protein kinase kinase kinase 6 isoform X4

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060925.1 Alternate T2T-CHM13v2.0

      Range
      27196422..27208199 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054339514.1XP_054195489.1  mitogen-activated protein kinase kinase kinase 6 isoform X1

    2. XM_054339516.1XP_054195491.1  mitogen-activated protein kinase kinase kinase 6 isoform X3

    3. XM_054339515.1XP_054195490.1  mitogen-activated protein kinase kinase kinase 6 isoform X2

    4. XM_054339517.1XP_054195492.1  mitogen-activated protein kinase kinase kinase 6 isoform X4

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_145319.1: Suppressed sequence

      Description
      NM_145319.1: This RefSeq record was removed by NCBI staff. Contact info@ncbi.nlm.nih.gov for further information.