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    Paqr8 progestin and adipoQ receptor family member VIII [ Mus musculus (house mouse) ]

    Gene ID: 74229, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Paqr8provided by MGI
    Official Full Name
    progestin and adipoQ receptor family member VIIIprovided by MGI
    Primary source
    MGI:MGI:1921479
    See related
    Ensembl:ENSMUSG00000025931 AllianceGenome:MGI:1921479
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    mPR beta; 1700019B16Rik; 3110001D06Rik
    Summary
    Predicted to enable nuclear steroid receptor activity and steroid binding activity. Predicted to be involved in response to steroid hormone. Predicted to be located in Golgi apparatus. Predicted to be active in plasma membrane. Orthologous to human PAQR8 (progestin and adipoQ receptor family member 8). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in cerebellum adult (RPKM 28.5), adrenal adult (RPKM 18.6) and 15 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Paqr8 in Genome Data Viewer
    Location:
    1 A4; 1 6.5 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (20960772..21009874)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (20890548..20939650)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 24723 Neighboring gene STARR-seq mESC enhancer starr_00392 Neighboring gene RIKEN cDNA 6720483E21 gene Neighboring gene STARR-seq mESC enhancer starr_00394 Neighboring gene STARR-seq mESC enhancer starr_00395 Neighboring gene predicted gene, 24171 Neighboring gene STARR-positive B cell enhancer mm9_chr1:20929159-20929460 Neighboring gene predicted gene, 51618 Neighboring gene STARR-seq mESC enhancer starr_00396 Neighboring gene EF-hand domain (C-terminal) containing 1 Neighboring gene STARR-seq mESC enhancer starr_00397 Neighboring gene CapStarr-seq enhancer MGSCv37_chr1:20985434-20985617 Neighboring gene translocating chain-associating membrane protein 2 Neighboring gene STARR-positive B cell enhancer mm9_chr1:21030259-21030560

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. PAQR8 promotes breast cancer recurrence and confers resistance to multiple therapies. Chen S, et al. Breast Cancer Res, 2023 Jan 3. PMID 36597146, Free PMC Article
    2. Genome-Wide Off-Target Analysis in CRISPR-Cas9 Modified Mice and Their Offspring. Dong Y, et al. G3 (Bethesda), 2019 Nov 5. PMID 31492696, Free PMC Article
    3. Progesterone-facilitated lordosis of estradiol-primed mice is attenuated by knocking down expression of membrane progestin receptors in the midbrain. Frye CA, et al. Steroids, 2014 Mar. PMID 24269738, Free PMC Article
    4. A novel gene in the chromosomal region for juvenile myoclonic epilepsy on 6p12 encodes a brain-specific lysosomal membrane protein. Suzuki T, et al. Biochem Biophys Res Commun, 2001 Nov 2. PMID 11676489
    5. Identification, classification, and partial characterization of genes in humans and other vertebrates homologous to a fish membrane progestin receptor. Zhu Y, et al. Proc Natl Acad Sci U S A, 2003 Mar 4. PMID 12601167, Free PMC Article

    See all (26) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Functional Analysis of Mmd2 and Related PAQR Genes During Sex Determination in Mice.
      Title: Functional Analysis of Mmd2 and Related PAQR Genes During Sex Determination in Mice.
    2. PAQR8 promotes breast cancer recurrence and confers resistance to multiple therapies.
      Title: PAQR8 promotes breast cancer recurrence and confers resistance to multiple therapies.
    3. Paqr7 and Paqr8 are expressed in the midbrain ventral tegmental area of proestrous mice.
      Title: Progesterone-facilitated lordosis of estradiol-primed mice is attenuated by knocking down expression of membrane progestin receptors in the midbrain.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables nuclear steroid receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables steroid binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables steroid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in oogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in response to steroid hormone IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    membrane progestin receptor beta
    Names
    lysosomal membrane protein in brain 1
    membrane progesterone P4 receptor beta
    membrane progesterone receptor beta
    progesterone and adipoQ receptor family member 8
    progestin and adipoQ receptor family member 8

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001355122.2 → NP_001342051.1  membrane progestin receptor beta

      Status: VALIDATED

      Source sequence(s)
      AC156980
      Consensus CDS
      CCDS14844.1
      UniProtKB/Swiss-Prot
      Q3UHI5, Q80ZE5, Q8C891, Q8CCW9, Q9DA71
      Related
      ENSMUSP00000069127.8, ENSMUST00000068880.14
      Conserved Domains (1) summary
      pfam03006
      Location:70 → 297
      HlyIII; Haemolysin-III related

    2. NM_001432941.1 → NP_001419870.1  membrane progestin receptor beta

      Status: VALIDATED

      Source sequence(s)
      AC156980
      UniProtKB/Swiss-Prot
      Q3UHI5, Q80ZE5, Q8C891, Q8CCW9, Q9DA71

    3. NM_001432942.1 → NP_001419871.1  membrane progestin receptor beta

      Status: VALIDATED

      Source sequence(s)
      AC156980
      UniProtKB/Swiss-Prot
      Q3UHI5, Q80ZE5, Q8C891, Q8CCW9, Q9DA71

    4. NM_028829.5 → NP_083105.3  membrane progestin receptor beta

      See identical proteins and their annotated locations for NP_083105.3

      Status: VALIDATED

      Source sequence(s)
      AC156980
      Consensus CDS
      CCDS14844.1
      UniProtKB/Swiss-Prot
      Q3UHI5, Q80ZE5, Q8C891, Q8CCW9, Q9DA71
      Related
      ENSMUSP00000141054.2, ENSMUST00000189400.7
      Conserved Domains (1) summary
      pfam03006
      Location:70 → 297
      HlyIII; Haemolysin-III related

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      20960772..21009874
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030243207.2 → XP_030099067.1  membrane progestin receptor beta isoform X1

      Conserved Domains (1) summary
      pfam03006
      Location:70 → 297
      HlyIII; Haemolysin-III related
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q80ZE5.2 GenPept UniProtKB/Swiss-Prot:Q80ZE5

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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