Klra2 killer cell lectin-like receptor, subfamily A, member 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Klra2provided by MGI
Official Full Name: killer cell lectin-like receptor, subfamily A, member 2provided by MGI
Primary source: MGI:MGI:101906
See related: Ensembl:ENSMUSG00000030187 AllianceGenome:MGI:101906
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Ly49b; Klra30
Summary: The gene is a member of the large lectin-like type 2 transmembrane receptor family of the natural killer gene complex. The gene is located distantly telomeric to its family's gene cluster on chromosome 6. The gene differs from the other genes in its cluster as its promoter region contains long and short interspersed repetitive elements suggesting a possible rearrangement or gene conversion. It is unknown whether this gene's encoded protein is involved with natural killer cell differentiation as are its other family members. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2010]
Expression: Low expression observed in reference dataset See more
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Genomic context

Location:: 6 F3; 6 63.44 cM

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	6	NC_000072.7 (131196190..131224679, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	6	NC_000072.6 (131198970..131247716, complement)

Chromosome 6 - NC_000072.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

BALB/c, but not the C57, isoform of Ly49B displays promiscuous MHC class I binding.
Title: Mutagenesis of Ly49B reveals key structural elements required for promiscuous binding to MHC class I molecules and new insights into the molecular evolution of Ly49s.
Ly49B is expressed at low levels on approximately 1.5% of spleen cells, none which are NK cells or T cells but which instead belong to several distinct subpopulations of myeloid cells.
Title: Ly49B is expressed on multiple subpopulations of myeloid cells.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)

General gene information

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Markers

U10304 (e-PCR)
- UniSTS:179476

Klra2 (e-PCR), detects polymorphism
- UniSTS:186752

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables carbohydrate binding	IEA Inferred from Electronic Annotation more info
enables signaling receptor activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in cell adhesion	IEA Inferred from Electronic Annotation more info
involved_in regulation of signal transduction	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in cell surface	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	TAS Traceable Author Statement more info	PubMed

General protein information

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Preferred Names: killer cell lectin-like receptor 2

Names: NK cell inhibitory receptor Klra2; T-cell surface glycoprotein Ly-49B; T-cell surface glycoprotein Ly49b; killer cell lectin-like receptor subfamily A member 30; ly-49b; lymphocyte antigen 49b; membrane protein Ly49b

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001170851.2 → NP_001164322.1 killer cell lectin-like receptor 2 isoform 1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).

Source sequence(s)

AC148326, AC163356

Consensus CDS

CCDS51929.1

UniProtKB/TrEMBL

A0FK58, E9Q433

Related

ENSMUSP00000086252.7, ENSMUST00000088867.7

Conserved Domains (2) summary

cd03593
Location:146 → 294

CLECT_NK_receptors_like; C-type lectin-like domain (CTLD) of the type found in natural killer cell receptors (NKRs)

pfam08391
Location:40 → 159

Ly49; Ly49-like protein, N-terminal region
NM_008462.6 → NP_032488.4 killer cell lectin-like receptor 2 isoform 2

See identical proteins and their annotated locations for NP_032488.4

Status: VALIDATED

Description

Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 3' coding region compared to variant 1. The encoded isoform (2) is shorter compared to isoform 1.

Source sequence(s)

AC148326, AC163356

Consensus CDS

CCDS20603.1

UniProtKB/TrEMBL

Q6P263, Q9D3R1, Q9JHG5

Related

ENSMUSP00000032306.9, ENSMUST00000032306.15

Conserved Domains (2) summary

cd03593
Location:146 → 261

CLECT_NK_receptors_like; C-type lectin-like domain (CTLD) of the type found in natural killer cell receptors (NKRs)

pfam08391
Location:40 → 159

Ly49; Ly49-like protein, N-terminal region

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000072.7 Reference GRCm39 C57BL/6J

Range

131196190..131224679 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036165887.1 → XP_036021780.1 killer cell lectin-like receptor 2 isoform X4

Conserved Domains (2) summary

cd03593
Location:55 → 203

CLECT_NK_receptors_like; C-type lectin-like domain (CTLD) of the type found in natural killer cell receptors (NKRs)

pfam08391
Location:1 → 68

Ly49; Ly49-like protein, N-terminal region
XM_017321416.2 → XP_017176905.1 killer cell lectin-like receptor 2 isoform X1

Conserved Domains (2) summary

cd03593
Location:253 → 401

CLECT_NK_receptors_like; C-type lectin-like domain (CTLD) of the type found in natural killer cell receptors (NKRs)

pfam08391
Location:147 → 266

Ly49; Ly49-like protein, N-terminal region
XM_017321414.2 → XP_017176903.1 killer cell lectin-like receptor 2 isoform X2

Conserved Domains (2) summary

cd03593
Location:253 → 368

CLECT_NK_receptors_like; C-type lectin-like domain (CTLD) of the type found in natural killer cell receptors (NKRs)

pfam08391
Location:147 → 266

Ly49; Ly49-like protein, N-terminal region
XM_017321415.2 → XP_017176904.1 killer cell lectin-like receptor 2 isoform X3

Conserved Domains (1) summary

pfam08391
Location:147 → 248

Ly49; Ly49-like protein, N-terminal region