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    TCF4 transcription factor 4 [ Homo sapiens (human) ]

    Gene ID: 6925, updated on 2-Nov-2024

    Summary

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    Official Symbol
    TCF4provided by HGNC
    Official Full Name
    transcription factor 4provided by HGNC
    Primary source
    HGNC:HGNC:11634
    See related
    Ensembl:ENSG00000196628 MIM:602272; AllianceGenome:HGNC:11634
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    E2-2; FCD2; ITF2; PTHS; SEF2; CDG2T; FECD3; ITF-2; SEF-2; TCF-4; SEF2-1; SEF2-1A; SEF2-1B; SEF2-1D; bHLHb19
    Summary
    This gene encodes transcription factor 4, a basic helix-loop-helix transcription factor. The encoded protein recognizes an Ephrussi-box ('E-box') binding site ('CANNTG') - a motif first identified in immunoglobulin enhancers. This gene is broadly expressed, and may play an important role in nervous system development. Defects in this gene are a cause of Pitt-Hopkins syndrome. In addition, an intronic CTG repeat normally numbering 10-37 repeat units can expand to >50 repeat units and cause Fuchs endothelial corneal dystrophy. Multiple alternatively spliced transcript variants that encode different proteins have been described. [provided by RefSeq, Jul 2016]
    Annotation information
    Note: TCF4 (Gene ID: 6925) and TCF7L2 (Gene ID: 6934) loci share the TCF4 symbol/alias in common. TCF4 is a widely used alternative name for T-cell-specific transcription factor 4 (TCF7L2) conflicting with the official symbol for transcription factor 4 (TCF4). [08 Feb 2019]
    Expression
    Ubiquitous expression in brain (RPKM 17.0), fat (RPKM 14.9) and 24 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See TCF4 in Genome Data Viewer
    Location:
    18q21.2
    Exon count:
    32
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 18 NC_000018.10 (55222185..55635957, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 18 NC_060942.1 (55425274..55839077, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 18 NC_000018.9 (52889416..53303188, complement)

    Chromosome 18 - NC_000018.10Genomic Context describing neighboring genes Neighboring gene long intergenic non-protein coding RNA 1929 Neighboring gene RNA, 5S ribosomal pseudogene 459 Neighboring gene NANOG hESC enhancer GRCh37_chr18:52881645-52882231 Neighboring gene Sharpr-MPRA regulatory region 5538 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13352 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13353 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13354 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13355 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13356 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13357 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13358 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9473 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr18:52936433-52937632 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9474 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr18:53017604-53018299 Neighboring gene VISTA enhancer hs1537 Neighboring gene VISTA enhancer hs376 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr18:53106079-53106856 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr18:53155630-53156322 Neighboring gene TCF4 antisense RNA 1 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr18:53176779-53177297 Neighboring gene microRNA 4529 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr18:53249412-53250006 Neighboring gene transcription factor 4 repeat instability region Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13360 Neighboring gene uncharacterized LOC105372126 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr18:53295077-53295576 Neighboring gene uncharacterized LOC105372130 Neighboring gene ribosomal protein L21 pseudogene 126 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr18:53388528-53389317 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr18:53420614-53421813 Neighboring gene Sharpr-MPRA regulatory region 1296 Neighboring gene long intergenic non-protein coding RNA 1415 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr18:53500200-53501399 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr18:53517802-53518302 Neighboring gene uncharacterized LOC107985183 Neighboring gene H3K27ac hESC enhancer GRCh37_chr18:53525319-53525818

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. TCF4 (e2-2; ITF2): a schizophrenia-associated gene with pleiotropic effects on human disease. Navarrete K, et al. Am J Med Genet B Neuropsychiatr Genet, 2013 Jan. PMID 23129290
    2. Disease-causing variants in TCF4 are a frequent cause of intellectual disability: lessons from large-scale sequencing approaches in diagnosis. Mary L, et al. Eur J Hum Genet, 2018 Jul. PMID 29695756, Free PMC Article
    3. TCF4 gene polymorphism and cognitive performance in patients with first episode psychosis. Albanna A, et al. Schizophr Res, 2014 Jan. PMID 24275585
    4. Absence of low frequency variants associated with schizophrenia at the ultraconserved non-coding region of TCF4. González-Penas J, et al. Psychiatry Res, 2014 Jan 30. PMID 24210665
    5. Building a schizophrenia genetic network: transcription factor 4 regulates genes involved in neuronal development and schizophrenia risk. Xia H, et al. Hum Mol Genet, 2018 Sep 15. PMID 29905862, Free PMC Article

    See all (306) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. MALAT1/miR-7-5p/TCF4 Axis Regulating Menstrual Blood Mesenchymal Stem Cells Improve Thin Endometrium Fertility by the Wnt Signaling Pathway.
      Title: MALAT1/miR-7-5p/TCF4 Axis Regulating Menstrual Blood Mesenchymal Stem Cells Improve Thin Endometrium Fertility by the Wnt Signaling Pathway.
    2. Circ_0004674 regulation of glycolysis and proliferation mechanism of osteosarcoma through miR-140-3p/TCF4 pathway.
      Title: Circ_0004674 regulation of glycolysis and proliferation mechanism of osteosarcoma through miR-140-3p/TCF4 pathway.
    3. CTG18.1 expansion in transcription factor 4 (TCF4) in corneal graft failure: preliminary study.
      Title: CTG18.1 expansion in transcription factor 4 (TCF4) in corneal graft failure: preliminary study.
    4. Deciphering novel TCF4-driven mechanisms underlying a common triplet repeat expansion-mediated disease.
      Title: Deciphering novel TCF4-driven mechanisms underlying a common triplet repeat expansion-mediated disease.
    5. DNA methylation episignature and comparative epigenomic profiling for Pitt-Hopkins syndrome caused by TCF4 variants.
      Title: DNA methylation episignature and comparative epigenomic profiling for Pitt-Hopkins syndrome caused by TCF4 variants.
    6. Dysregulation of the TCF4 Isoform in Corneal Endothelial Cells of Patients With Fuchs Endothelial Corneal Dystrophy.
      Title: Dysregulation of the TCF4 Isoform in Corneal Endothelial Cells of Patients With Fuchs Endothelial Corneal Dystrophy.
    7. Transcription factor 4 promotes increased corneal endothelial cellular migration by altering microtubules in Fuchs endothelial corneal dystrophy.
      Title: Transcription factor 4 promotes increased corneal endothelial cellular migration by altering microtubules in Fuchs endothelial corneal dystrophy.
    8. AMD1 promotes breast cancer aggressiveness via a spermidine-eIF5A hypusination-TCF4 axis.
      Title: AMD1 promotes breast cancer aggressiveness via a spermidine-eIF5A hypusination-TCF4 axis.
    9. Suppression of TCF4 promotes a ZC3H12A-mediated self-sustaining inflammatory feedback cycle involving IL-17RA/IL-17RE epidermal signaling.
      Title: Suppression of TCF4 promotes a ZC3H12A-mediated self-sustaining inflammatory feedback cycle involving IL-17RA/IL-17RE epidermal signaling.
    10. TCF4 Mutations Disrupt Synaptic Function Through Dysregulation of RIMBP2 in Patient-Derived Cortical Neurons.
      Title: TCF4 Mutations Disrupt Synaptic Function Through Dysregulation of RIMBP2 in Patient-Derived Cortical Neurons.
    Submit: New GeneRIF Correction See all GeneRIFs (183)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Associated conditions

    Description Tests
    Corneal dystrophy, Fuchs endothelial, 3
    MedGen: C2750451 OMIM: 613267 GeneReviews: Not available
    		not available
    Pitt-Hopkins syndrome
    MedGen: C1970431 OMIM: 610954 GeneReviews: Pitt-Hopkins Syndrome
    		not available

    Copy number response

    Description
    Copy number response
    Triplosensitivity

    No evidence available (Last evaluated 2020-07-08)

    ClinGen Genome Curation Page
    Haploinsufficency

    Sufficient evidence for dosage pathogenicity (Last evaluated 2020-07-08)

    ClinGen Genome Curation PagePubMed

    EBI GWAS Catalog

    Description
    A comprehensive family-based replication study of schizophrenia genes.
    EBI GWAS Catalog
    Biological insights from 108 schizophrenia-associated genetic loci.
    EBI GWAS Catalog
    Common polygenic variation contributes to risk of schizophrenia and bipolar disorder.
    EBI GWAS Catalog
    Common variants conferring risk of schizophrenia.
    EBI GWAS Catalog
    E2-2 protein and Fuchs's corneal dystrophy.
    EBI GWAS Catalog
    Genome-wide association analysis identifies 13 new risk loci for schizophrenia.
    EBI GWAS Catalog
    Genome-wide association analysis in primary sclerosing cholangitis and ulcerative colitis identifies risk loci at GPR35 and TCF4.
    EBI GWAS Catalog
    Genome-wide association study identifies five new schizophrenia loci.
    EBI GWAS Catalog
    Genome-wide association study in a Swedish population yields support for greater CNV and MHC involvement in schizophrenia compared with bipolar disorder.
    EBI GWAS Catalog
    Genome-wide meta-analysis for severe diabetic retinopathy.
    EBI GWAS Catalog
    Genome-wide SNP and CNV analysis identifies common and low-frequency variants associated with severe early-onset obesity.
    EBI GWAS Catalog
    Identification of risk loci with shared effects on five major psychiatric disorders: a genome-wide analysis.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC149723, MGC149724

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables DNA-binding transcription activator activity, RNA polymerase II-specific ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables DNA-binding transcription factor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables DNA-binding transcription factor activity, RNA polymerase II-specific ISA
    Inferred from Sequence Alignment
    more info
    		  
    enables DNA-binding transcription factor activity, RNA polymerase II-specific ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables E-box binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables TFIIB-class transcription factor binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables beta-catenin binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein heterodimerization activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables sequence-specific double-stranded DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cell differentiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in nervous system development IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of DNA-templated transcription IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of neuron differentiation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in positive regulation of transcription by RNA polymerase II ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    involved_in protein-DNA complex assembly ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of beta-catenin-TCF complex IPI
    Inferred from Physical Interaction
    more info
    		  
    part_of beta-catenin-TCF7L2 complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in chromatin IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in chromatin IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in chromatin ISA
    Inferred from Sequence Alignment
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of transcription regulator complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of transcription regulator complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    transcription factor 4
    Names
    SL3-3 enhancer factor 2
    class B basic helix-loop-helix protein 19
    immunoglobulin transcription factor 2

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_011716.2 RefSeqGene

      Range
      52802..418809
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001083962.2 → NP_001077431.1  transcription factor 4 isoform a

      See identical proteins and their annotated locations for NP_001077431.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) differs in the 5' UTR and coding sequence compared to variant 3. The resulting isoform (a, also known as TCF4-B+) is shorter at the N-terminus compared to isoform c.
      Source sequence(s)
      AC091103, AK122765, BC125084, BJ989626
      Consensus CDS
      CCDS42438.1
      UniProtKB/TrEMBL
      B3KVA4
      Related
      ENSP00000346440.3, ENST00000354452.8
      Conserved Domains (1) summary
      cd18945
      Location:562 → 646
      bHLH_E-protein_TCF4_E2-2; basic helix-loop-helix (bHLH) domain found in transcription factor 4 (TCF-4) and similar proteins

    2. NM_001243226.3 → NP_001230155.2  transcription factor 4 isoform c precursor

      See identical proteins and their annotated locations for NP_001230155.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) encodes the longest isoform (c).
      Source sequence(s)
      AC091103, AK315074, BC031056, BC125085, HY051304
      Consensus CDS
      CCDS58631.1
      UniProtKB/TrEMBL
      A0A1B0GVR6, E9PH57
      Related
      ENSP00000381382.1, ENST00000398339.5
      Conserved Domains (1) summary
      smart00353
      Location:676 → 729
      HLH; helix loop helix domain

    3. NM_001243227.2 → NP_001230156.1  transcription factor 4 isoform d

      See identical proteins and their annotated locations for NP_001230156.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR and coding sequence compared to variant 3. The resulting isoform (d) is shorter at the N-terminus compared to isoform c.
      Source sequence(s)
      AC091103, AK299169
      Consensus CDS
      CCDS58629.1
      UniProtKB/TrEMBL
      B3KVA4
      Related
      ENSP00000440731.1, ENST00000537578.5
      Conserved Domains (1) summary
      cd18945
      Location:538 → 622
      bHLH_E-protein_TCF4_E2-2; basic helix-loop-helix (bHLH) domain found in transcription factor 4 (TCF-4) and similar proteins

    4. NM_001243228.2 → NP_001230157.1  transcription factor 4 isoform e

      See identical proteins and their annotated locations for NP_001230157.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) differs in the 5' UTR and coding sequence and uses an alternate in-frame splice site at the 5' end of an exon compared to variant 3. The resulting isoform (e) is shorter at the N-terminus and contains an alternate internal segment compared to isoform c.
      Source sequence(s)
      AC091103, AK299169, AK315074
      Consensus CDS
      CCDS58630.1
      UniProtKB/TrEMBL
      B3KVA4, H3BTP3
      Related
      ENSP00000457263.1, ENST00000564403.6
      Conserved Domains (1) summary
      smart00353
      Location:580 → 633
      HLH; helix loop helix domain

    5. NM_001243230.2 → NP_001230159.1  transcription factor 4 isoform f

      See identical proteins and their annotated locations for NP_001230159.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (6) differs in the 5' UTR and coding sequence and uses an alternate in-frame splice site at the 3' end of an exon compared to variant 3. The resulting isoform (f, also known as TCF4-E-) has a shorter and distinct N-terminus and lacks an alternate internal segment compared to isoform c.
      Source sequence(s)
      AC091103, AK122765, FR748216
      Consensus CDS
      CCDS59321.1
      UniProtKB/TrEMBL
      B3KVA4
      Related
      ENSP00000455418.2, ENST00000566286.5
      Conserved Domains (1) summary
      smart00353
      Location:567 → 620
      HLH; helix loop helix domain

    6. NM_001243231.2 → NP_001230160.1  transcription factor 4 isoform g

      See identical proteins and their annotated locations for NP_001230160.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (7) differs in the 5' UTR and coding sequence and uses an alternate in-frame splice site at the 3' end of an exon compared to variant 3. The resulting isoform (g) has a shorter and distinct N-terminus and lacks an alternate internal segment compared to isoform c.
      Source sequence(s)
      AC018994, AC091103, AK096862
      Consensus CDS
      CCDS58628.1
      UniProtKB/TrEMBL
      B3KVA4
      Related
      ENSP00000439656.1, ENST00000543082.5
      Conserved Domains (1) summary
      cd18945
      Location:516 → 600
      bHLH_E-protein_TCF4_E2-2; basic helix-loop-helix (bHLH) domain found in transcription factor 4 (TCF-4) and similar proteins

    7. NM_001243232.1 → NP_001230161.1  transcription factor 4 isoform h

      See identical proteins and their annotated locations for NP_001230161.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (8) differs in the 5' UTR and coding sequence and uses an alternate in-frame splice site at the 5' end of an exon compared to variant 3. The resulting isoform (h) has a shorter and distinct N-terminus and contains an alternate internal segment compared to isoform c.
      Source sequence(s)
      AC091103, AK095041
      Consensus CDS
      CCDS58627.1
      UniProtKB/TrEMBL
      B3KVA4
      Related
      ENSP00000441562.2, ENST00000544241.6
      Conserved Domains (1) summary
      cd18945
      Location:491 → 575
      bHLH_E-protein_TCF4_E2-2; basic helix-loop-helix (bHLH) domain found in transcription factor 4 (TCF-4) and similar proteins

    8. NM_001243233.2 → NP_001230162.1  transcription factor 4 isoform i

      See identical proteins and their annotated locations for NP_001230162.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (9) differs in the 5' UTR and coding sequence and uses an alternate in-frame splice site at the 3' end of an exon compared to variant 3. The resulting isoform (i) is shorter at the N-terminus and lacks an alternate internal segment compared to isoform c.
      Source sequence(s)
      AC091103, AK300612
      Consensus CDS
      CCDS58626.1
      UniProtKB/TrEMBL
      B3KVA4
      Related
      ENSP00000455179.1, ENST00000561992.5
      Conserved Domains (1) summary
      cd18945
      Location:428 → 512
      bHLH_E-protein_TCF4_E2-2; basic helix-loop-helix (bHLH) domain found in transcription factor 4 (TCF-4) and similar proteins

    9. NM_001243234.2 → NP_001230163.1  transcription factor 4 isoform j

      See identical proteins and their annotated locations for NP_001230163.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (10) differs in the 5' UTR and coding sequence compared to variant 3. The resulting isoform (j, also known as TCF4-A+) has a shorter and distinct N-terminus compared to isoform c.
      Source sequence(s)
      AC091103, AK300038, DC298029, FR748220
      Consensus CDS
      CCDS58624.1
      UniProtKB/Swiss-Prot
      P15884
      Related
      ENSP00000409447.2, ENST00000457482.7
      Conserved Domains (1) summary
      cd18945
      Location:402 → 486
      bHLH_E-protein_TCF4_E2-2; basic helix-loop-helix (bHLH) domain found in transcription factor 4 (TCF-4) and similar proteins

    10. NM_001243235.2 → NP_001230164.1  transcription factor 4 isoform k

      See identical proteins and their annotated locations for NP_001230164.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (11) differs in the 5' UTR and coding sequence and uses an alternate in-frame splice site at the 3' end of an exon compared to variant 3. The resulting isoform (k, also known as TCF4-A-) has a shorter and distinct N-terminus and lacks an alternate internal segment compared to isoform c.
      Source sequence(s)
      AC091103, AK300038, DC298029, FR748221
      Consensus CDS
      CCDS58625.1
      UniProtKB/Swiss-Prot
      P15884
      Related
      ENSP00000455763.1, ENST00000570287.6
      Conserved Domains (1) summary
      cd18945
      Location:398 → 482
      bHLH_E-protein_TCF4_E2-2; basic helix-loop-helix (bHLH) domain found in transcription factor 4 (TCF-4) and similar proteins

    11. NM_001243236.2 → NP_001230165.1  transcription factor 4 isoform l

      See identical proteins and their annotated locations for NP_001230165.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (12) differs in the 5' UTR and coding sequence and uses an alternate in-frame splice site at the 3' end of an exon compared to variant 3. The resulting isoform (l) has a shorter and distinct N-terminus and lacks an alternate internal segment compared to isoform c.
      Source sequence(s)
      AC091103, AK300038, AL518903, FR748222
      Consensus CDS
      CCDS58623.1
      UniProtKB/Swiss-Prot
      P15884
      Related
      ENSP00000457765.1, ENST00000561831.7
      Conserved Domains (1) summary
      cd18945
      Location:398 → 482
      bHLH_E-protein_TCF4_E2-2; basic helix-loop-helix (bHLH) domain found in transcription factor 4 (TCF-4) and similar proteins

    12. NM_001306207.1 → NP_001293136.1  transcription factor 4 isoform m

      See identical proteins and their annotated locations for NP_001293136.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (13) differs in the 5' UTR and coding sequence, and uses an alternate in-frame splice site in the 3' coding region, compared to variant 3. The encoded isoform (m) has a shorter N-terminus compared to isoform c.
      Source sequence(s)
      AC091103, AK301144, BP293388
      Consensus CDS
      CCDS77192.1
      UniProtKB/TrEMBL
      B3KVA4
      Related
      ENSP00000445202.1, ENST00000540999.5
      Conserved Domains (1) summary
      cd18945
      Location:534 → 618
      bHLH_E-protein_TCF4_E2-2; basic helix-loop-helix (bHLH) domain found in transcription factor 4 (TCF-4) and similar proteins

    13. NM_001306208.1 → NP_001293137.1  transcription factor 4 isoform n

      See identical proteins and their annotated locations for NP_001293137.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (14) differs in the 5' UTR and coding sequence, and uses two alternate in-frame splice sites in the coding region, compared to variant 3. The encoded isoform (n) has a shorter and distinct N-terminus compared to isoform c.
      Source sequence(s)
      AC091103, AK095041, FR748219
      Consensus CDS
      CCDS77191.1
      UniProtKB/TrEMBL
      B3KVA4
      Related
      ENSP00000455261.1, ENST00000564228.5
      Conserved Domains (1) summary
      cd18945
      Location:487 → 571
      bHLH_E-protein_TCF4_E2-2; basic helix-loop-helix (bHLH) domain found in transcription factor 4 (TCF-4) and similar proteins

    14. NM_001330604.3 → NP_001317533.1  transcription factor 4 isoform o

      Status: REVIEWED

      Description
      Transcript Variant: This variant (15) differs in the 5' UTR, lacks a portion of the 5' coding region, initiates translation at a downstream start codon, and uses an alternate in-frame splice site in the central coding region, compared to variant 3. The resulting isoform (o) is shorter at the N-terminus and lacks an internal aa compared to isoform c.
      Source sequence(s)
      AC013587, AC018994, AC090684, AC091103
      UniProtKB/TrEMBL
      B3KVA4
      Related
      ENSP00000490625.2, ENST00000638154.3
      Conserved Domains (1) summary
      cd18945
      Location:561 → 645
      bHLH_E-protein_TCF4_E2-2; basic helix-loop-helix (bHLH) domain found in transcription factor 4 (TCF-4) and similar proteins

    15. NM_001330605.3 → NP_001317534.1  transcription factor 4 isoform p

      Status: REVIEWED

      Description
      Transcript Variant: This variant (16) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream start codon, compared to variant 3. The resulting isoform (p) is shorter at the N-terminus compared to isoform c. Variants 16 and 19 encode the same isoform (p).
      Source sequence(s)
      AC013587, AC091103
      Consensus CDS
      CCDS82255.1
      UniProtKB/TrEMBL
      A0A1B0GWD5, B3KVA4
      Related
      ENSP00000494380.1, ENST00000643689.1
      Conserved Domains (1) summary
      cd18945
      Location:432 → 516
      bHLH_E-protein_TCF4_E2-2; basic helix-loop-helix (bHLH) domain found in transcription factor 4 (TCF-4) and similar proteins

    16. NM_001348211.2 → NP_001335140.1  transcription factor 4 isoform q

      Status: REVIEWED

      Description
      Transcript Variant: This variant (17) contains an alternate exon in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at an alternate start codon, compared to variant 3. The resulting isoform (q) is shorter at the N-terminus compared to isoform c.
      Source sequence(s)
      AC018994, AC091103, AK096862, BM011452
      UniProtKB/TrEMBL
      B3KVA4
      Conserved Domains (1) summary
      cd18945
      Location:520 → 604
      bHLH_E-protein_TCF4_E2-2; basic helix-loop-helix (bHLH) domain found in transcription factor 4 (TCF-4) and similar proteins

    17. NM_001348212.2 → NP_001335141.1  transcription factor 4 isoform i

      Status: REVIEWED

      Description
      Transcript Variant: This variant (18) differs in the 5' UTR, lacks a portion of the 5' coding region, initiates translation at a downstream start codon, and uses an alternate in-frame splice site in the 3' coding region, compared to variant 3. The resulting isoform (i) is shorter at the N-terminus and lacks a small internal segment compared to isoform c. Variants 9 and 18 encode the same isoform (i).
      Source sequence(s)
      AC091103, AK300612, DC358599
      Consensus CDS
      CCDS58626.1
      UniProtKB/TrEMBL
      B3KVA4
      Related
      ENSP00000439827.2, ENST00000537856.7
      Conserved Domains (1) summary
      cd18945
      Location:428 → 512
      bHLH_E-protein_TCF4_E2-2; basic helix-loop-helix (bHLH) domain found in transcription factor 4 (TCF-4) and similar proteins

    18. NM_001348213.2 → NP_001335142.1  transcription factor 4 isoform p

      Status: REVIEWED

      Description
      Transcript Variant: This variant (19) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream start codon, compared to variant 3. The resulting isoform (p) is shorter at the N-terminus compared to isoform c. Variants 16 and 19 encode the same isoform (p).
      Source sequence(s)
      AC091103, AK300612, BM011452, DC358599
      Consensus CDS
      CCDS82255.1
      UniProtKB/TrEMBL
      A0A1B0GWD5, B3KVA4
      Related
      ENSP00000501758.1, ENST00000675707.1
      Conserved Domains (1) summary
      cd18945
      Location:432 → 516
      bHLH_E-protein_TCF4_E2-2; basic helix-loop-helix (bHLH) domain found in transcription factor 4 (TCF-4) and similar proteins

    19. NM_001348214.2 → NP_001335143.1  transcription factor 4 isoform r

      Status: REVIEWED

      Description
      Transcript Variant: This variant (20) contains an alternate exon in the 5' UTR, lacks a portion of the 5' coding region, initiates translation at an alternate start codon, and uses two alternate in-frame splice sites, compared to variant 3. The resulting isoform (r) is shorter at the N-terminus and lacks several internal amino acids compared to isoform c
      Source sequence(s)
      AC091103, AK300038, DC298029, FR748216, FR748221
      UniProtKB/Swiss-Prot
      P15884
      Conserved Domains (1) summary
      smart00353
      Location:409 → 462
      HLH; helix loop helix domain

    20. NM_001348215.2 → NP_001335144.1  transcription factor 4 isoform s

      Status: REVIEWED

      Description
      Transcript Variant: This variant (21) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream start codon, compared to variant 3. The resulting isoform (s) is shorter at the N-terminus compared to isoform c.
      Source sequence(s)
      AC013587, AC091103, AK096862, BM011452
      Consensus CDS
      CCDS86671.1
      UniProtKB/TrEMBL
      A0A1B0GW91
      Related
      ENSP00000490832.1, ENST00000637169.2
      Conserved Domains (1) summary
      cd18945
      Location:346 → 430
      bHLH_E-protein_TCF4_E2-2; basic helix-loop-helix (bHLH) domain found in transcription factor 4 (TCF-4) and similar proteins

    21. NM_001348216.2 → NP_001335145.1  transcription factor 4 isoform t

      Status: REVIEWED

      Description
      Transcript Variant: This variant (22) contains an alternate exon in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at an alternate start codon, compared to variant 3. The resulting isoform (t) is shorter at the N-terminus compared to isoform c.
      Source sequence(s)
      AC091103, AK096862, BM011452, DA664480
      UniProtKB/Swiss-Prot
      P15884
      Conserved Domains (1) summary
      smart00353
      Location:414 → 467
      HLH; helix loop helix domain

    22. NM_001348217.1 → NP_001335146.1  transcription factor 4 isoform d

      Status: REVIEWED

      Description
      Transcript Variant: This variant (23) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream start codon, compared to variant 3. The resulting isoform (d) is shorter at the N-terminus compared to isoform c. Variants 4, 23 and 24 all encode the same isoform (d).
      Source sequence(s)
      AC091103, AK299169, AK301144, BP293388
      Consensus CDS
      CCDS58629.1
      UniProtKB/TrEMBL
      B3KVA4
      Related
      ENSP00000455135.1, ENST00000568673.5
      Conserved Domains (1) summary
      cd18945
      Location:538 → 622
      bHLH_E-protein_TCF4_E2-2; basic helix-loop-helix (bHLH) domain found in transcription factor 4 (TCF-4) and similar proteins

    23. NM_001348218.2 → NP_001335147.1  transcription factor 4 isoform d

      Status: REVIEWED

      Description
      Transcript Variant: This variant (24) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream start codon, compared to variant 3. The resulting isoform (d) is shorter at the N-terminus compared to isoform c. Variants 4, 23 and 24 all encode the same isoform (d).
      Source sequence(s)
      AC018994, AC091103, AK299169, BP293388
      Consensus CDS
      CCDS58629.1
      UniProtKB/TrEMBL
      B3KVA4
      Conserved Domains (1) summary
      cd18945
      Location:538 → 622
      bHLH_E-protein_TCF4_E2-2; basic helix-loop-helix (bHLH) domain found in transcription factor 4 (TCF-4) and similar proteins

    24. NM_001348219.2 → NP_001335148.1  transcription factor 4 isoform m

      Status: REVIEWED

      Description
      Transcript Variant: This variant (25) differs in the 5' UTR, lacks a portion of the 5' coding region, initiates translation at a downstream start codon, and uses an alternate in-frame splice site in the 3' coding region compared to variant 3. The resulting isoform (m) is shorter at the N-terminus and lacks an alternate internal segment compared to isoform c. Variants 13 and 25 encode the same isoform (m).
      Source sequence(s)
      AC018994, AC091103, AK301144, BP293388
      Consensus CDS
      CCDS77192.1
      UniProtKB/TrEMBL
      B3KVA4
      Conserved Domains (1) summary
      cd18945
      Location:534 → 618
      bHLH_E-protein_TCF4_E2-2; basic helix-loop-helix (bHLH) domain found in transcription factor 4 (TCF-4) and similar proteins

    25. NM_001348220.1 → NP_001335149.1  transcription factor 4 isoform u

      Status: REVIEWED

      Description
      Transcript Variant: This variant (26) differs in the 5' UTR, lacks a portion of the 5' coding region, initiates translation at a downstream start codon, and uses two alternate in-frame splice sites compared to variant 3. The resulting isoform (u) is shorter at the N-terminus and lacks several internal amino acids compared to isoform c.
      Source sequence(s)
      AC091103, AK301144, BP293388
      Consensus CDS
      CCDS86672.1
      UniProtKB/TrEMBL
      B3KVA4, H3BPJ7
      Conserved Domains (1) summary
      cd18945
      Location:533 → 617
      bHLH_E-protein_TCF4_E2-2; basic helix-loop-helix (bHLH) domain found in transcription factor 4 (TCF-4) and similar proteins

    26. NM_001369567.1 → NP_001356496.1  transcription factor 4 isoform a

      Status: REVIEWED

      Source sequence(s)
      AC013587, AC018994, AC090684, AC091103
      Consensus CDS
      CCDS42438.1
      UniProtKB/TrEMBL
      B3KVA4
      Related
      ENSP00000486670.1, ENST00000629387.2
      Conserved Domains (1) summary
      cd18945
      Location:562 → 646
      bHLH_E-protein_TCF4_E2-2; basic helix-loop-helix (bHLH) domain found in transcription factor 4 (TCF-4) and similar proteins

    27. NM_001369568.1 → NP_001356497.1  transcription factor 4 isoform a

      Status: REVIEWED

      Source sequence(s)
      AC013587, AC018994, AC090684, AC091103
      Consensus CDS
      CCDS42438.1
      UniProtKB/TrEMBL
      B3KVA4
      Conserved Domains (1) summary
      cd18945
      Location:562 → 646
      bHLH_E-protein_TCF4_E2-2; basic helix-loop-helix (bHLH) domain found in transcription factor 4 (TCF-4) and similar proteins

    28. NM_001369569.1 → NP_001356498.1  transcription factor 4 isoform v

      Status: REVIEWED

      Source sequence(s)
      AC013587, AC018994, AC090684, AC091103
      UniProtKB/TrEMBL
      B3KVA4
      Related
      ENSP00000456125.1, ENST00000566279.5
      Conserved Domains (1) summary
      cd18945
      Location:561 → 645
      bHLH_E-protein_TCF4_E2-2; basic helix-loop-helix (bHLH) domain found in transcription factor 4 (TCF-4) and similar proteins

    29. NM_001369570.1 → NP_001356499.1  transcription factor 4 isoform v

      Status: REVIEWED

      Source sequence(s)
      AC013587, AC018994, AC090684, AC091103
      UniProtKB/TrEMBL
      B3KVA4
      Conserved Domains (1) summary
      cd18945
      Location:561 → 645
      bHLH_E-protein_TCF4_E2-2; basic helix-loop-helix (bHLH) domain found in transcription factor 4 (TCF-4) and similar proteins

    30. NM_001369571.1 → NP_001356500.1  transcription factor 4 isoform b

      Status: REVIEWED

      Source sequence(s)
      AC013587, AC018994, AC090684, AC091103
      Consensus CDS
      CCDS11960.1
      UniProtKB/Swiss-Prot
      B3KT62, B3KUC0, B4DT37, B4DUG3, B7Z5M6, B7Z6Y1, G0LNT9, G0LNU0, G0LNU1, G0LNU2, G0LNU4, G0LNU5, G0LNU8, G0LNU9, G0LNV0, G0LNV1, G0LNV2, H3BPQ1, P15884, Q08AP2, Q08AP3, Q15439, Q15440, Q15441
      UniProtKB/TrEMBL
      B3KVA4
      Conserved Domains (1) summary
      cd18945
      Location:558 → 642
      bHLH_E-protein_TCF4_E2-2; basic helix-loop-helix (bHLH) domain found in transcription factor 4 (TCF-4) and similar proteins

    31. NM_001369572.1 → NP_001356501.1  transcription factor 4 isoform b

      Status: REVIEWED

      Source sequence(s)
      AC013587, AC018994, AC090684, AC091103
      Consensus CDS
      CCDS11960.1
      UniProtKB/Swiss-Prot
      B3KT62, B3KUC0, B4DT37, B4DUG3, B7Z5M6, B7Z6Y1, G0LNT9, G0LNU0, G0LNU1, G0LNU2, G0LNU4, G0LNU5, G0LNU8, G0LNU9, G0LNV0, G0LNV1, G0LNV2, H3BPQ1, P15884, Q08AP2, Q08AP3, Q15439, Q15440, Q15441
      UniProtKB/TrEMBL
      B3KVA4
      Related
      ENSP00000457649.1, ENST00000564999.5
      Conserved Domains (1) summary
      cd18945
      Location:558 → 642
      bHLH_E-protein_TCF4_E2-2; basic helix-loop-helix (bHLH) domain found in transcription factor 4 (TCF-4) and similar proteins

    32. NM_001369573.1 → NP_001356502.1  transcription factor 4 isoform x

      Status: REVIEWED

      Source sequence(s)
      AC013587, AC018994, AC090684, AC091103
      UniProtKB/TrEMBL
      B3KVA4
      Related
      ENSP00000478549.1, ENST00000616053.4
      Conserved Domains (1) summary
      cd18945
      Location:557 → 641
      bHLH_E-protein_TCF4_E2-2; basic helix-loop-helix (bHLH) domain found in transcription factor 4 (TCF-4) and similar proteins

    33. NM_001369574.1 → NP_001356503.1  transcription factor 4 isoform 27

      Status: REVIEWED

      Source sequence(s)
      AC013587, AC018994, AC090684, AC091103
      UniProtKB/TrEMBL
      B3KVA4
      Conserved Domains (1) summary
      cd18945
      Location:557 → 641
      bHLH_E-protein_TCF4_E2-2; basic helix-loop-helix (bHLH) domain found in transcription factor 4 (TCF-4) and similar proteins

    34. NM_001369575.1 → NP_001356504.1  transcription factor 4 isoform d

      Status: REVIEWED

      Source sequence(s)
      AC013587, AC018994, AC090684, AC091103
      Consensus CDS
      CCDS58629.1
      UniProtKB/TrEMBL
      B3KVA4
      Conserved Domains (1) summary
      cd18945
      Location:538 → 622
      bHLH_E-protein_TCF4_E2-2; basic helix-loop-helix (bHLH) domain found in transcription factor 4 (TCF-4) and similar proteins

    35. NM_001369576.1 → NP_001356505.1  transcription factor 4 isoform y

      Status: REVIEWED

      Source sequence(s)
      AC013587, AC018994, AC090684, AC091103
      UniProtKB/TrEMBL
      B3KVA4
      Conserved Domains (1) summary
      cd18945
      Location:537 → 621
      bHLH_E-protein_TCF4_E2-2; basic helix-loop-helix (bHLH) domain found in transcription factor 4 (TCF-4) and similar proteins

    36. NM_001369577.1 → NP_001356506.1  transcription factor 4 isoform 28

      Status: REVIEWED

      Source sequence(s)
      AC013587, AC018994, AC090684, AC091103
      UniProtKB/TrEMBL
      B3KVA4
      Conserved Domains (1) summary
      cd18945
      Location:537 → 621
      bHLH_E-protein_TCF4_E2-2; basic helix-loop-helix (bHLH) domain found in transcription factor 4 (TCF-4) and similar proteins

    37. NM_001369578.1 → NP_001356507.1  transcription factor 4 isoform y

      Status: REVIEWED

      Source sequence(s)
      AC013587, AC018994, AC090684, AC091103
      UniProtKB/TrEMBL
      B3KVA4
      Conserved Domains (1) summary
      cd18945
      Location:537 → 621
      bHLH_E-protein_TCF4_E2-2; basic helix-loop-helix (bHLH) domain found in transcription factor 4 (TCF-4) and similar proteins

    38. NM_001369579.1 → NP_001356508.1  transcription factor 4 isoform 28

      Status: REVIEWED

      Source sequence(s)
      AC013587, AC018994, AC090684, AC091103
      UniProtKB/TrEMBL
      B3KVA4
      Conserved Domains (1) summary
      cd18945
      Location:537 → 621
      bHLH_E-protein_TCF4_E2-2; basic helix-loop-helix (bHLH) domain found in transcription factor 4 (TCF-4) and similar proteins

    39. NM_001369580.1 → NP_001356509.1  transcription factor 4 isoform 28

      Status: REVIEWED

      Source sequence(s)
      AC013587, AC018994, AC090684, AC091103
      UniProtKB/TrEMBL
      B3KVA4
      Conserved Domains (1) summary
      cd18945
      Location:537 → 621
      bHLH_E-protein_TCF4_E2-2; basic helix-loop-helix (bHLH) domain found in transcription factor 4 (TCF-4) and similar proteins

    40. NM_001369581.1 → NP_001356510.1  transcription factor 4 isoform y

      Status: REVIEWED

      Source sequence(s)
      AC013587, AC018994, AC090684, AC091103
      UniProtKB/TrEMBL
      B3KVA4
      Conserved Domains (1) summary
      cd18945
      Location:537 → 621
      bHLH_E-protein_TCF4_E2-2; basic helix-loop-helix (bHLH) domain found in transcription factor 4 (TCF-4) and similar proteins

    41. NM_001369582.1 → NP_001356511.1  transcription factor 4 isoform m

      Status: REVIEWED

      Source sequence(s)
      AC013587, AC018994, AC090684, AC091103
      Consensus CDS
      CCDS77192.1
      UniProtKB/TrEMBL
      B3KVA4
      Conserved Domains (1) summary
      cd18945
      Location:534 → 618
      bHLH_E-protein_TCF4_E2-2; basic helix-loop-helix (bHLH) domain found in transcription factor 4 (TCF-4) and similar proteins

    42. NM_001369583.1 → NP_001356512.1  transcription factor 4 isoform m

      Status: REVIEWED

      Source sequence(s)
      AC013587, AC018994, AC090684, AC091103
      Consensus CDS
      CCDS77192.1
      UniProtKB/TrEMBL
      B3KVA4
      Conserved Domains (1) summary
      cd18945
      Location:534 → 618
      bHLH_E-protein_TCF4_E2-2; basic helix-loop-helix (bHLH) domain found in transcription factor 4 (TCF-4) and similar proteins

    43. NM_001369584.1 → NP_001356513.1  transcription factor 4 isoform u

      Status: REVIEWED

      Source sequence(s)
      AC013587, AC018994, AC090684, AC091103
      Consensus CDS
      CCDS86672.1
      UniProtKB/TrEMBL
      B3KVA4, H3BPJ7
      Related
      ENSP00000455346.1, ENST00000568740.5
      Conserved Domains (1) summary
      cd18945
      Location:533 → 617
      bHLH_E-protein_TCF4_E2-2; basic helix-loop-helix (bHLH) domain found in transcription factor 4 (TCF-4) and similar proteins

    44. NM_001369585.1 → NP_001356514.1  transcription factor 4 isoform u

      Status: REVIEWED

      Source sequence(s)
      AC013587, AC018994, AC090684, AC091103
      Consensus CDS
      CCDS86672.1
      UniProtKB/TrEMBL
      B3KVA4, H3BPJ7
      Conserved Domains (1) summary
      cd18945
      Location:533 → 617
      bHLH_E-protein_TCF4_E2-2; basic helix-loop-helix (bHLH) domain found in transcription factor 4 (TCF-4) and similar proteins

    45. NM_001369586.1 → NP_001356515.1  transcription factor 4 isoform z

      Status: REVIEWED

      Source sequence(s)
      AC013587, AC018994, AC090684, AC091103
      UniProtKB/TrEMBL
      B3KVA4
      Conserved Domains (1) summary
      smart00353
      Location:551 → 604
      HLH; helix loop helix domain

    46. NM_003199.3 → NP_003190.1  transcription factor 4 isoform b

      See identical proteins and their annotated locations for NP_003190.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR and coding sequence and uses an alternate in-frame splice site at the 3' end of an exon compared to variant 3. The resulting isoform (b, also known as TCF4-B-) is shorter at the N-terminus and lacks an alternate internal segment compared to isoform c.
      Source sequence(s)
      AC091103, BJ989626, M74719
      Consensus CDS
      CCDS11960.1
      UniProtKB/Swiss-Prot
      B3KT62, B3KUC0, B4DT37, B4DUG3, B7Z5M6, B7Z6Y1, G0LNT9, G0LNU0, G0LNU1, G0LNU2, G0LNU4, G0LNU5, G0LNU8, G0LNU9, G0LNV0, G0LNV1, G0LNV2, H3BPQ1, P15884, Q08AP2, Q08AP3, Q15439, Q15440, Q15441
      UniProtKB/TrEMBL
      B3KVA4
      Related
      ENSP00000348374.4, ENST00000356073.8
      Conserved Domains (1) summary
      cd18945
      Location:558 → 642
      bHLH_E-protein_TCF4_E2-2; basic helix-loop-helix (bHLH) domain found in transcription factor 4 (TCF-4) and similar proteins

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000018.10 Reference GRCh38.p14 Primary Assembly

      Range
      55222185..55635957 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060942.1 Alternate T2T-CHM13v2.0

      Range
      55425274..55839077 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P15884.3 GenPept UniProtKB/Swiss-Prot:P15884

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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