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    Tcea2 transcription elongation factor A (SII), 2 [ Mus musculus (house mouse) ]

    Gene ID: 21400, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Tcea2provided by MGI
    Official Full Name
    transcription elongation factor A (SII), 2provided by MGI
    Primary source
    MGI:MGI:107368
    See related
    Ensembl:ENSMUSG00000059540 AllianceGenome:MGI:107368
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Tceat; SII-T1; S-II-T1
    Summary
    Predicted to enable DNA binding activity and zinc ion binding activity. Predicted to be involved in positive regulation of transcription by RNA polymerase II. Predicted to be located in centrosome and nucleoplasm. Predicted to be active in nucleus. Is expressed in several structures, including central nervous system; genitourinary system; inner ear; lung epithelium; and spleen. Orthologous to human TCEA2 (transcription elongation factor A2). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in testis adult (RPKM 125.6), cortex adult (RPKM 23.3) and 8 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Tcea2 in Genome Data Viewer
    Location:
    2 H4; 2 103.72 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (181322090..181329860)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (181680297..181688067)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene predicted gene, 25879 Neighboring gene SRY (sex determining region Y)-box 18 Neighboring gene regulator of G-protein signaling 19 Neighboring gene LKAAEAR motif containing 1 (IKAAEAR murine motif)

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Spermatocyte-specific expression of the gene for mouse testis-specific transcription elongation factor S-II. Ito T, et al. FEBS Lett, 1996 Apr 29. PMID 8641458
    2. The RNA polymerase II general elongation factors. Reines D, et al. Trends Biochem Sci, 1996 Sep. PMID 8870500, Free PMC Article
    3. Restricted expression of a member of the transcription elongation factor S-II family in testicular germ cells during and after meiosis. Umehara T, et al. J Biochem, 1997 Mar. PMID 9133631
    4. Transcription factor genes and the developing eye: a genetic perspective. Freund C, et al. Hum Mol Genet, 1996. PMID 8875254
    5. Gene organization and chromosome mapping of the testis-specific S-II. Ito T, et al. Mamm Genome, 1998 Nov. PMID 9799847

    See all (28) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. role in regulating GRIP1tau
      Title: GRIP1tau, a novel PDZ domain-containing transcriptional activator, cooperates with the testis-specific transcription elongation factor SII-T1.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in transcription elongation by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in centrosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in centrosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    transcription elongation factor A protein 2
    Names
    testis-specific S-II
    transcription elongation factor S-II protein 2
    transcription elongation factor TFIIS.l

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001356342.1 → NP_001343271.1  transcription elongation factor A protein 2 isoform b

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate splice junction in the 5' end compared to variant 1. The resulting isoform (b) is shorter at the N-terminus compared to isoform a. Variants 2 and 3 both encode the same isoform (b).
      Source sequence(s)
      AK137527, AL844529, BE990349
      UniProtKB/TrEMBL
      Q3UV78
      Related
      ENSMUSP00000119646.2, ENSMUST00000129745.8
      Conserved Domains (1) summary
      TIGR01385
      Location:1 → 273
      TFSII; transcription elongation factor S-II

    2. NM_001356343.1 → NP_001343272.1  transcription elongation factor A protein 2 isoform b

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) uses an alternate splice junction in the 5' end compared to variant 1. The resulting isoform (b) is shorter at the N-terminus compared to isoform a. Variants 2 and 3 both encode the same isoform (b).
      Source sequence(s)
      AL844529
      UniProtKB/TrEMBL
      Q3UV78
      Conserved Domains (1) summary
      TIGR01385
      Location:1 → 273
      TFSII; transcription elongation factor S-II

    3. NM_009326.3 → NP_033352.1  transcription elongation factor A protein 2 isoform a

      See identical proteins and their annotated locations for NP_033352.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (a).
      Source sequence(s)
      BC049617, BE990349, BY143976
      Consensus CDS
      CCDS17219.1
      UniProtKB/Swiss-Prot
      O08667, Q9QVN7
      UniProtKB/TrEMBL
      Q3UV78, Q6P072, Q810R3
      Related
      ENSMUSP00000099331.4, ENSMUST00000103042.10
      Conserved Domains (5) summary
      cd00183
      Location:4 → 80
      TFIIS_I; N-terminal domain (domain I) of transcription elongation factor S-II (TFIIS); similar to a domain found in elongin A and CRSP70; likely to be involved in transcription; domain I from TFIIS interacts with RNA polymerase II holoenzyme
      cd13749
      Location:252 → 298
      Zn-ribbon_TFIIS; domain III/zinc ribbon domain of Transcription Factor IIS
      TIGR01385
      Location:5 → 299
      TFSII; transcription elongation factor S-II
      pfam07500
      Location:136 → 243
      TFIIS_M; Transcription factor S-II (TFIIS), central domain
      pfam15223
      Location:87 → 148
      DUF4584; Domain of unknown function (DUF4584)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      181322090..181329860
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9QVN7.2 GenPept UniProtKB/Swiss-Prot:Q9QVN7

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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