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    Fuom fucose mutarotase [ Mus musculus (house mouse) ]

    Gene ID: 69064, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Fuomprovided by MGI
    Official Full Name
    fucose mutarotaseprovided by MGI
    Primary source
    MGI:MGI:1916314
    See related
    Ensembl:ENSMUSG00000025466 AllianceGenome:MGI:1916314
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Fucu; Le51
    Summary
    Enables L-fucose mutarotase activity and fucose binding activity. Involved in GDP-L-fucose salvage and fucose metabolic process. Acts upstream of or within female mating behavior; fucosylation; and negative regulation of neuron differentiation. Is active in cytosol. Orthologous to human FUOM (fucose mutarotase). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in duodenum adult (RPKM 5.8), kidney adult (RPKM 4.8) and 27 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Fuom in Genome Data Viewer
    Location:
    7 F4; 7 85.11 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (139677724..139684745, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (140097811..140104832, complement)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_20446 Neighboring gene calcyon neuron-specific vesicular protein Neighboring gene STARR-seq mESC enhancer starr_20447 Neighboring gene proline-rich acidic protein 1 Neighboring gene enoyl Coenzyme A hydratase, short chain, 1, mitochondrial Neighboring gene polyamine oxidase (exo-N4-amino) Neighboring gene STARR-positive B cell enhancer ABC_E1747 Neighboring gene mitochondrial ribosome-associated GTPase 1 Neighboring gene shadow of prion protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. A novel system for expressing recombinant proteins over a wide temperature range from 4 to 35 degrees C. Nakashima N, et al. Biotechnol Bioeng, 2004 Apr 20. PMID 15052633
    2. Characterization and role of fucose mutarotase in mammalian cells. Park D, et al. Glycobiology, 2007 Sep. PMID 17602138
    3. Male-like sexual behavior of female mouse lacking fucose mutarotase. Park D, et al. BMC Genet, 2010 Jul 7. PMID 20609214, Free PMC Article
    4. Crystal structures and enzyme mechanisms of a dual fucose mutarotase/ribose pyranase. Lee KH, et al. J Mol Biol, 2009 Aug 7. PMID 19524593
    5. Crystal structures of RbsD leading to the identification of cytoplasmic sugar-binding proteins with a novel folding architecture. Kim MS, et al. J Biol Chem, 2003 Jul 25. PMID 12738765

    See all (17) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (1)  1 citation

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Clone Names

    • 1810014F10Rik

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables L-fucose mutarotase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables fucose binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables fucose binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables fucose binding ISA
    Inferred from Sequence Alignment
    more info
    		 PubMed 
    enables racemase and epimerase activity, acting on carbohydrates and derivatives IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables racemase and epimerase activity, acting on carbohydrates and derivatives IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in GDP-L-fucose salvage IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within female mating behavior IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in fucose metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in fucose metabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in fucose metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in fucosylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within fucosylation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within negative regulation of neuron differentiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of neuron differentiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    fucose mutarotase
    Names
    protein fucU homolog
    NP_001273146.1
    NP_001273147.2
    NP_081204.2
    XP_011248157.1
    XP_030098825.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001286217.2 → NP_001273146.1  fucose mutarotase isoform 2

      See identical proteins and their annotated locations for NP_001273146.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate splice site in the 3'-terminal exon, compared to variant 1. The encoded isoform (2) has a longer and distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      AC109205
      UniProtKB/TrEMBL
      F6SJM7
      Related
      ENSMUSP00000115799.2, ENSMUST00000142105.8
      Conserved Domains (1) summary
      cl00809
      Location:4 → 133
      RbsD_FucU; RbsD / FucU transport protein family

    2. NM_001286218.2 → NP_001273147.2  fucose mutarotase isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) lacks an exon in the central coding region, which results in a frameshift and initiation from an alternate start codon, compared to variant 1. The encoded isoform (3) is shorter and has a distinct N-terminus, compared to isoform 1.
      Source sequence(s)
      AC109205
      Conserved Domains (1) summary
      pfam05025
      Location:46 → 99
      RbsD_FucU; RbsD / FucU transport protein family

    3. NM_026928.4 → NP_081204.2  fucose mutarotase isoform 1

      See identical proteins and their annotated locations for NP_081204.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes isoform 1.
      Source sequence(s)
      AC109205
      Consensus CDS
      CCDS40173.1
      UniProtKB/Swiss-Prot
      Q3TQB6, Q76K68, Q8C566, Q8C8P5, Q8R2K1
      UniProtKB/TrEMBL
      D3YWS7
      Related
      ENSMUSP00000026539.8, ENSMUST00000026539.14
      Conserved Domains (1) summary
      cl00809
      Location:4 → 146
      RbsD_FucU; RbsD / FucU transport protein family

    RNA

    1. NR_104415.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) uses an alternate splice site at an internal exon, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AC109205, AK044731

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      139677724..139684745 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030242965.1 → XP_030098825.1  fucose mutarotase isoform X1

      UniProtKB/TrEMBL
      F6SJM7
      Conserved Domains (1) summary
      pfam05025
      Location:5 → 149
      RbsD_FucU; RbsD / FucU transport protein family

    2. XM_011249855.3 → XP_011248157.1  fucose mutarotase isoform X2

      UniProtKB/TrEMBL
      D3YWS7
      Conserved Domains (1) summary
      pfam05025
      Location:5 → 159
      RbsD_FucU; RbsD / FucU transport protein family

    RNA

    1. XR_004934184.1 RNA Sequence

    2. XR_003946558.1 RNA Sequence

    3. XR_004934183.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8R2K1.1 GenPept UniProtKB/Swiss-Prot:Q8R2K1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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