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    Rpl35a ribosomal protein L35A [ Mus musculus (house mouse) ]

    Gene ID: 57808, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Rpl35aprovided by MGI
    Official Full Name
    ribosomal protein L35Aprovided by MGI
    Primary source
    MGI:MGI:1928894
    See related
    Ensembl:ENSMUSG00000060636 AllianceGenome:MGI:1928894
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Rpl35; 2810431L15Rik
    Summary
    A structural constituent of ribosome. Predicted to be involved in cytoplasmic translation; rRNA processing; and ribosomal large subunit biogenesis. Located in cytoplasm. Part of cytosolic large ribosomal subunit. Is active in synapse. Is expressed in central nervous system; cranium; gut; inner ear; and submandibular gland primordium. Human ortholog(s) of this gene implicated in Diamond-Blackfan anemia 5. Orthologous to human RPL35A (ribosomal protein L35a). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in liver E14 (RPKM 309.5), bladder adult (RPKM 301.0) and 24 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Rpl35a in Genome Data Viewer
    Location:
    16 B3; 16 23.59 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (32876823..32880559)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (33056453..33060189)

    Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene leucine-rich repeats and calponin homology (CH) domain containing 3 Neighboring gene nuclear encoded rRNA 5S 33 Neighboring gene STARR-seq mESC enhancer starr_40679 Neighboring gene STARR-positive B cell enhancer ABC_E8628 Neighboring gene IQ motif containing G Neighboring gene STARR-positive B cell enhancer ABC_E2460 Neighboring gene leishmanolysin-like (metallopeptidase M8 family) Neighboring gene microRNA 1947 Neighboring gene predicted gene, 38540

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Cloning, sequencing and expression of a cDNA encoding the mouse L35a ribosomal protein during differentiation of murine erythroleukemia (MEL) cells. Pappas IS, et al. Cell Biol Int, 2001. PMID 11448102
    2. cDNA subtraction cloning reveals novel genes whose temporal and spatial expression indicates association with trophoblast invasion. Hemberger M, et al. Dev Biol, 2000 Jun 1. PMID 10885754
    3. A male germ-cell-specific ribosome controls male fertility. Li H, et al. Nature, 2022 Dec. PMID 36517592
    4. In-depth protein profiling of the postsynaptic density from mouse hippocampus using data-independent acquisition proteomics. Distler U, et al. Proteomics, 2014 Nov. PMID 25211037
    5. Ribosome-mediated specificity in Hox mRNA translation and vertebrate tissue patterning. Kondrashov N, et al. Cell, 2011 Apr 29. PMID 21529712, Free PMC Article

    See all (29) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables structural constituent of ribosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables structural constituent of ribosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables structural constituent of ribosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in cytoplasmic translation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cytoplasmic translation NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in rRNA processing ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in ribosomal large subunit biogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in ribosomal large subunit biogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in translation at postsynapse NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in translation at presynapse NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytosol TAS
    Traceable Author Statement
    more info
    		  
    part_of cytosolic large ribosomal subunit IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of cytosolic large ribosomal subunit IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of cytosolic large ribosomal subunit IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    part_of cytosolic large ribosomal subunit ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosolic ribosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrion HDA PubMed 
    is_active_in postsynapse NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    is_active_in presynapse NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    is_active_in ribosome NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    is_active_in synapse EXP
    Inferred from Experiment
    more info
    		 PubMed 
    is_active_in synapse IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    large ribosomal subunit protein eL33
    Names
    60S ribosomal protein L35a

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001130484.1 → NP_001123956.1  large ribosomal subunit protein eL33

      See identical proteins and their annotated locations for NP_001123956.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1.
      Source sequence(s)
      BB611247, CJ043213
      Consensus CDS
      CCDS28126.1
      UniProtKB/Swiss-Prot
      O55142
      UniProtKB/TrEMBL
      Q6ZWX1, Q8BQV7, Q9DC85
      Related
      ENSMUSP00000110731.2, ENSMUST00000115079.8
      Conserved Domains (1) summary
      pfam01247
      Location:5 → 103
      Ribosomal_L35Ae; Ribosomal protein L35Ae

    2. NM_001130485.1 → NP_001123957.1  large ribosomal subunit protein eL33

      See identical proteins and their annotated locations for NP_001123957.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR, compared to variant 1.
      Source sequence(s)
      AK010692, BB611247, BU530423
      Consensus CDS
      CCDS28126.1
      UniProtKB/Swiss-Prot
      O55142
      UniProtKB/TrEMBL
      Q6ZWX1, Q8BQV7, Q9DC85
      Related
      ENSMUSP00000077857.6, ENSMUST00000078804.12
      Conserved Domains (1) summary
      pfam01247
      Location:5 → 103
      Ribosomal_L35Ae; Ribosomal protein L35Ae

    3. NM_021338.3 → NP_067313.2  large ribosomal subunit protein eL33

      See identical proteins and their annotated locations for NP_067313.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript.
      Source sequence(s)
      AK028214, AV486753, BB611247
      Consensus CDS
      CCDS28126.1
      UniProtKB/Swiss-Prot
      O55142
      UniProtKB/TrEMBL
      Q6ZWX1, Q8BQV7, Q9DC85
      Related
      ENSMUSP00000110730.2, ENSMUST00000115078.8
      Conserved Domains (1) summary
      pfam01247
      Location:5 → 103
      Ribosomal_L35Ae; Ribosomal protein L35Ae

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000082.7 Reference GRCm39 C57BL/6J

      Range
      32876823..32880559
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O55142.2 GenPept UniProtKB/Swiss-Prot:O55142

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