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    Neo1 neogenin [ Mus musculus (house mouse) ]

    Gene ID: 18007, updated on 2-Nov-2024

    Summary

    Official Symbol
    Neo1provided by MGI
    Official Full Name
    neogeninprovided by MGI
    Primary source
    MGI:MGI:1097159
    See related
    Ensembl:ENSMUSG00000032340 AllianceGenome:MGI:1097159
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Igdcc2; 2610028H22Rik; D930014N22Rik
    Summary
    Enables BMP receptor binding activity; cadherin binding activity; and signaling receptor activity. Involved in trans-synaptic signaling, modulating synaptic transmission. Acts upstream of or within several processes, including myoblast fusion; negative regulation of axon regeneration; and positive regulation of BMP signaling pathway. Located in several cellular components, including cell surface; growth cone; and intracellular vesicle. Is active in glutamatergic synapse and postsynaptic density membrane. Is expressed in several structures, including alimentary system; genitourinary system; limb; nervous system; and sensory organ. Orthologous to human NEO1 (neogenin 1). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in CNS E18 (RPKM 24.1), limb E14.5 (RPKM 22.5) and 24 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Neo1 in Genome Data Viewer
    Location:
    9 B; 9 31.81 cM
    Exon count:
    29
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (58781962..58943926, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (58874679..59036614, complement)

    Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene REC114 meiotic recombination protein Neighboring gene STARR-seq mESC enhancer starr_24285 Neighboring gene predicted gene, 21183 Neighboring gene VISTA enhancer mm1997 Neighboring gene STARR-seq mESC enhancer starr_24288 Neighboring gene hyperpolarization-activated, cyclic nucleotide-gated K+ 4 Neighboring gene STARR-seq mESC enhancer starr_24289 Neighboring gene STARR-seq mESC enhancer starr_24290 Neighboring gene STARR-seq mESC enhancer starr_24291 Neighboring gene ribosomal protein S10 pseudogene Neighboring gene predicted gene, 53529

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables BMP receptor binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables cadherin binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables co-receptor binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables co-receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables signaling receptor activity IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in axon guidance IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in cell adhesion IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cell-cell adhesion IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within intracellular iron ion homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within multicellular organismal-level iron ion homeostasis ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within myoblast fusion IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within negative regulation of axon regeneration IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within negative regulation of protein secretion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in neuron migration IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within positive regulation of BMP signaling pathway IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of protein secretion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within regulation of DNA-templated transcription IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within regulation of axon regeneration IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in trans-synaptic signaling, modulating synaptic transmission IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in trans-synaptic signaling, modulating synaptic transmission IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
     
    located_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in axonal growth cone IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    is_active_in cell surface IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cell surface IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in glutamatergic synapse IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in glutamatergic synapse IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    is_active_in glutamatergic synapse NAS
    Non-traceable Author Statement
    more info
    PubMed 
    located_in growth cone IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in intracellular vesicle IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in neuronal cell body ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
     
    part_of plasma membrane protein complex IEA
    Inferred from Electronic Annotation
    more info
     
    part_of plasma membrane protein complex ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in postsynaptic density membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in postsynaptic density membrane IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    is_active_in postsynaptic density membrane NAS
    Non-traceable Author Statement
    more info
    PubMed 

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001042752.2NP_001036217.1  neogenin isoform 2 precursor

      See identical proteins and their annotated locations for NP_001036217.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate splice site and lacks an exon in the coding region compared to variant 1. The resulting protein (isoform 2) is shorter but has the same N- and C-termini compared to isoform 1.
      Source sequence(s)
      AC110530, CT033754
      Consensus CDS
      CCDS90582.1
      UniProtKB/TrEMBL
      Q7TQG5
      Related
      ENSMUSP00000150600.2, ENSMUST00000214547.2
      Conserved Domains (7) summary
      cd05722
      Location:65159
      Ig1_Neogenin; First immunoglobulin (Ig)-like domain in neogenin and similar proteins
      smart00408
      Location:274337
      IGc2; Immunoglobulin C-2 Type
      cd05723
      Location:368438
      Ig4_Neogenin; Fourth immunoglobulin (Ig)-like domain in neogenin and similar proteins
      smart00060
      Location:770849
      FN3; Fibronectin type 3 domain
      cd00063
      Location:570659
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam07679
      Location:352438
      I-set; Immunoglobulin I-set domain
      pfam06583
      Location:11621465
      Neogenin_C; Neogenin C-terminus
    2. NM_001408269.1NP_001395198.1  neogenin isoform 3 precursor

      Status: VALIDATED

      Source sequence(s)
      AC110530, CT033754
    3. NM_001408270.1NP_001395199.1  neogenin isoform 4 precursor

      Status: VALIDATED

      Source sequence(s)
      AC110530, CT033754
    4. NM_001408271.1NP_001395200.1  neogenin isoform 5 precursor

      Status: VALIDATED

      Source sequence(s)
      AC110530, CT033754
    5. NM_001408272.1NP_001395201.1  neogenin isoform 6 precursor

      Status: VALIDATED

      Source sequence(s)
      AC110530, CT033754
    6. NM_001408273.1NP_001395202.1  neogenin isoform 7 precursor

      Status: VALIDATED

      Source sequence(s)
      AC110530, CT033754
    7. NM_001408274.1NP_001395203.1  neogenin isoform 8 precursor

      Status: VALIDATED

      Source sequence(s)
      AC110530, CT033754
    8. NM_001408275.1NP_001395204.1  neogenin isoform 9 precursor

      Status: VALIDATED

      Source sequence(s)
      AC110530, CT033754
    9. NM_001408276.1NP_001395205.1  neogenin isoform 10 precursor

      Status: VALIDATED

      Source sequence(s)
      AC110530, CT033754
    10. NM_001408277.1NP_001395206.1  neogenin isoform 11 precursor

      Status: VALIDATED

      Source sequence(s)
      AC110530, CT033754
    11. NM_008684.3NP_032710.2  neogenin isoform 1 precursor

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest protein (isoform 1).
      Source sequence(s)
      AC110530, CT033754
      Consensus CDS
      CCDS23246.1
      UniProtKB/Swiss-Prot
      P97798
      UniProtKB/TrEMBL
      E9QK04
      Related
      ENSMUSP00000063656.6, ENSMUST00000068664.7
      Conserved Domains (7) summary
      cd05722
      Location:65159
      Ig1_Neogenin; First immunoglobulin (Ig)-like domain in neogenin and similar proteins
      smart00408
      Location:274337
      IGc2; Immunoglobulin C-2 Type
      cd05723
      Location:368438
      Ig4_Neogenin; Fourth immunoglobulin (Ig)-like domain in neogenin and similar proteins
      smart00060
      Location:770849
      FN3; Fibronectin type 3 domain
      cd00063
      Location:570659
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam07679
      Location:352438
      I-set; Immunoglobulin I-set domain
      pfam06583
      Location:11891492
      Neogenin_C; Neogenin C-terminus

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000075.7 Reference GRCm39 C57BL/6J

      Range
      58781962..58943926 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036154679.1XP_036010572.1  neogenin isoform X14

      Conserved Domains (9) summary
      smart00060
      Location:750829
      FN3; Fibronectin type 3 domain
      cd00063
      Location:550639
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam00041
      Location:647732
      fn3; Fibronectin type III domain
      pfam06583
      Location:11421392
      Neogenin_C; Neogenin C-terminus
      pfam07679
      Location:261348
      I-set; Immunoglobulin I-set domain
      cd00096
      Location:268272
      Ig; Ig strand A' [structural motif]
      cd05722
      Location:63159
      IgI_1_Neogenin_like; First immunoglobulin (Ig)-like domain in neogenin, and similar domains; member of the I-set of Ig superfamily (IgSF) domains
      cd05723
      Location:355438
      IgI_4_Neogenin_like; Fourth immunoglobulin (Ig)-like domain in neogenin, and similar domains; member of the I-set of Ig superfamily (IgSF) domains
      cl11960
      Location:163250
      Ig; Immunoglobulin domain
    2. XM_036154678.1XP_036010571.1  neogenin isoform X13

      Conserved Domains (9) summary
      smart00060
      Location:750829
      FN3; Fibronectin type 3 domain
      cd00063
      Location:550639
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam00041
      Location:647732
      fn3; Fibronectin type III domain
      pfam06583
      Location:11531403
      Neogenin_C; Neogenin C-terminus
      pfam07679
      Location:261348
      I-set; Immunoglobulin I-set domain
      cd00096
      Location:268272
      Ig; Ig strand A' [structural motif]
      cd05722
      Location:63159
      IgI_1_Neogenin_like; First immunoglobulin (Ig)-like domain in neogenin, and similar domains; member of the I-set of Ig superfamily (IgSF) domains
      cd05723
      Location:355438
      IgI_4_Neogenin_like; Fourth immunoglobulin (Ig)-like domain in neogenin, and similar domains; member of the I-set of Ig superfamily (IgSF) domains
      cl11960
      Location:163250
      Ig; Immunoglobulin domain
    3. XM_030244107.2XP_030099967.1  neogenin isoform X5

      Conserved Domains (8) summary
      cd05722
      Location:65159
      Ig1_Neogenin; First immunoglobulin (Ig)-like domain in neogenin and similar proteins
      cd05723
      Location:368438
      Ig4_Neogenin; Fourth immunoglobulin (Ig)-like domain in neogenin and similar proteins
      smart00060
      Location:750829
      FN3; Fibronectin type 3 domain
      cd00063
      Location:550639
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam00041
      Location:647730
      fn3; Fibronectin type III domain
      pfam06583
      Location:11531456
      Neogenin_C; Neogenin C-terminus
      pfam07679
      Location:261348
      I-set; Immunoglobulin I-set domain
      cl11960
      Location:163250
      Ig; Immunoglobulin domain
    4. XM_036154677.1XP_036010570.1  neogenin isoform X12

      Conserved Domains (9) summary
      smart00060
      Location:750829
      FN3; Fibronectin type 3 domain
      cd00063
      Location:550639
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam00041
      Location:647732
      fn3; Fibronectin type III domain
      pfam06583
      Location:11581408
      Neogenin_C; Neogenin C-terminus
      pfam07679
      Location:261348
      I-set; Immunoglobulin I-set domain
      cd00096
      Location:268272
      Ig; Ig strand A' [structural motif]
      cd05722
      Location:63159
      IgI_1_Neogenin_like; First immunoglobulin (Ig)-like domain in neogenin, and similar domains; member of the I-set of Ig superfamily (IgSF) domains
      cd05723
      Location:355438
      IgI_4_Neogenin_like; Fourth immunoglobulin (Ig)-like domain in neogenin, and similar domains; member of the I-set of Ig superfamily (IgSF) domains
      cl11960
      Location:163250
      Ig; Immunoglobulin domain
    5. XM_036154675.1XP_036010568.1  neogenin isoform X9

      Conserved Domains (9) summary
      smart00060
      Location:770849
      FN3; Fibronectin type 3 domain
      cd00063
      Location:570659
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam00041
      Location:667752
      fn3; Fibronectin type III domain
      pfam06583
      Location:11731423
      Neogenin_C; Neogenin C-terminus
      pfam07679
      Location:261348
      I-set; Immunoglobulin I-set domain
      cd00096
      Location:268272
      Ig; Ig strand A' [structural motif]
      cd05722
      Location:63159
      IgI_1_Neogenin_like; First immunoglobulin (Ig)-like domain in neogenin, and similar domains; member of the I-set of Ig superfamily (IgSF) domains
      cd05723
      Location:355438
      IgI_4_Neogenin_like; Fourth immunoglobulin (Ig)-like domain in neogenin, and similar domains; member of the I-set of Ig superfamily (IgSF) domains
      cl11960
      Location:163250
      Ig; Immunoglobulin domain