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    Pigl phosphatidylinositol glycan anchor biosynthesis, class L [ Mus musculus (house mouse) ]

    Gene ID: 327942, updated on 28-Oct-2024

    Summary

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    Official Symbol
    Piglprovided by MGI
    Official Full Name
    phosphatidylinositol glycan anchor biosynthesis, class Lprovided by MGI
    Primary source
    MGI:MGI:2681271
    See related
    Ensembl:ENSMUSG00000014245 AllianceGenome:MGI:2681271
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Gm737
    Summary
    Predicted to enable N-acetylglucosaminylphosphatidylinositol deacetylase activity. Predicted to be involved in GPI anchor biosynthetic process. Predicted to be located in endoplasmic reticulum membrane. Predicted to be active in endoplasmic reticulum. Human ortholog(s) of this gene implicated in CHIME syndrome. Orthologous to human PIGL (phosphatidylinositol glycan anchor biosynthesis class L). [provided by Alliance of Genome Resources, Oct 2024]
    Expression
    Ubiquitous expression in large intestine adult (RPKM 6.3), subcutaneous fat pad adult (RPKM 5.9) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Pigl in Genome Data Viewer
    Location:
    11 B2; 11 38.34 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (62349267..62406863)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (62458441..62516037)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene tetratricopeptide repeat domain 19 Neighboring gene anaphase-promoting complex subunit 15 pseudogene Neighboring gene nuclear receptor co-repressor 1 Neighboring gene STARR-seq mESC enhancer starr_29697 Neighboring gene STARR-seq mESC enhancer starr_29699 Neighboring gene STARR-seq mESC enhancer starr_29702 Neighboring gene STARR-seq mESC enhancer starr_29703 Neighboring gene STARR-seq mESC enhancer starr_29704 Neighboring gene STARR-seq mESC enhancer starr_29710 Neighboring gene STARR-seq mESC enhancer starr_29712 Neighboring gene STARR-seq mESC enhancer starr_29713 Neighboring gene centromere protein V Neighboring gene predicted gene 12279

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Placentation defects are highly prevalent in embryonic lethal mouse mutants. Perez-Garcia V, et al. Nature, 2018 Mar 22. PMID 29539633, Free PMC Article
    2. USP7 represses lineage differentiation genes in mouse embryonic stem cells by both catalytic and noncatalytic activities. Liu C, et al. Sci Adv, 2023 May 19. PMID 37196079, Free PMC Article
    3. Mouse screen reveals multiple new genes underlying mouse and human hearing loss. Ingham NJ, et al. PLoS Biol, 2019 Apr. PMID 30973865, Free PMC Article
    4. High-throughput discovery of novel developmental phenotypes. Dickinson ME, et al. Nature, 2016 Sep 22. PMID 27626380, Free PMC Article
    5. EUCOMM--the European conditional mouse mutagenesis program. Friedel RH, et al. Brief Funct Genomic Proteomic, 2007 Sep. PMID 17967808

    See all (22) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Gene trapped (1) 
    • Targeted (2) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC106811

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables N-acetylglucosaminylphosphatidylinositol deacetylase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables N-acetylglucosaminylphosphatidylinositol deacetylase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables N-acetylglucosaminylphosphatidylinositol deacetylase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in GPI anchor biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in GPI anchor biosynthetic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    is_active_in endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in endoplasmic reticulum membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    N-acetylglucosaminyl-phosphatidylinositol de-N-acetylase
    Names
    ortholog of human and rat phosphatidylinositol glycan class L PIGL
    phosphatidylinositol-glycan biosynthesis class L protein
    NP_001034625.1
    NP_001351700.1
    XP_036012661.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001039536.4 → NP_001034625.1  N-acetylglucosaminyl-phosphatidylinositol de-N-acetylase isoform 1

      See identical proteins and their annotated locations for NP_001034625.1

      Status: VALIDATED

      Source sequence(s)
      AL596181, BX248411, BX470084
      Consensus CDS
      CCDS24824.1
      UniProtKB/Swiss-Prot
      Q5SX19
      Related
      ENSMUSP00000014389.6, ENSMUST00000014389.6
      Conserved Domains (1) summary
      COG2120
      Location:37 → 252
      LmbE; N-acetylglucosaminyl deacetylase, LmbE family [Carbohydrate transport and metabolism]

    2. NM_001364771.2 → NP_001351700.1  N-acetylglucosaminyl-phosphatidylinositol de-N-acetylase isoform 2

      Status: VALIDATED

      Source sequence(s)
      BX248411, CR392047
      UniProtKB/TrEMBL
      Q4V9U8
      Conserved Domains (1) summary
      cl00929
      Location:45 → 79
      PIG-L; GlcNAc-PI de-N-acetylase

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      62349267..62406863
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036156768.1 → XP_036012661.1  N-acetylglucosaminyl-phosphatidylinositol de-N-acetylase isoform X1

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_199026.1: Suppressed sequence

      Description
      NM_199026.1: This RefSeq was permanently suppressed because it is a nonsense-mediated decay (NMD) candidate.
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5SX19.1 GenPept UniProtKB/Swiss-Prot:Q5SX19

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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