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    Dppa1 developmental pluripotency associated 1 [ Mus musculus (house mouse) ]

    Gene ID: 347708, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Dppa1provided by MGI
    Official Full Name
    developmental pluripotency associated 1provided by MGI
    Primary source
    MGI:MGI:2157522
    See related
    Ensembl:ENSMUSG00000064010 AllianceGenome:MGI:2157522
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Summary
    Predicted to enable phosphatidylserine binding activity and virus receptor activity. Predicted to be involved in phagocytosis, engulfment and positive regulation of mast cell activation. Predicted to be active in cell surface. Is expressed in several structures, including 2-cell stage embryo; adrenal gland; genitourinary system; gut; and nervous system. [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Low expression observed in reference dataset See more
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    Genomic context

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    See Dppa1 in Genome Data Viewer
    Location:
    11 B1.1; 11 28.02 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (46497837..46520249, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (46607010..46629274, complement)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_29332 Neighboring gene ribosomal protein L9, pseudogene 2 Neighboring gene T cell immunoglobulin and mucin domain containing 6 Neighboring gene T cell immunoglobulin and mucin domain containing 7, pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E3944 Neighboring gene T cell immunoglobulin and mucin domain containing 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Incomplete reactivation of Oct4-related genes in mouse embryos cloned from somatic nuclei. Bortvin A, et al. Development, 2003 Apr. PMID 12620990
    2. The ability of inner-cell-mass cells to self-renew as embryonic stem cells is acquired following epiblast specification. Boroviak T, et al. Nat Cell Biol, 2014 Jun. PMID 24859004, Free PMC Article
    3. Deterministic and stochastic allele specific gene expression in single mouse blastomeres. Tang F, et al. PLoS One, 2011. PMID 21731673, Free PMC Article
    4. Mouse screen reveals multiple new genes underlying mouse and human hearing loss. Ingham NJ, et al. PLoS Biol, 2019 Apr. PMID 30973865, Free PMC Article
    5. High-throughput discovery of novel developmental phenotypes. Dickinson ME, et al. Nature, 2016 Sep 22. PMID 27626380, Free PMC Article

    See all (21) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (2) 

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables phosphatidylserine binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables virus receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in phagocytosis, engulfment IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of mast cell activation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cell surface IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    developmental pluripotency associated 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001163358.1 → NP_001156830.1  developmental pluripotency associated 1 precursor

      See identical proteins and their annotated locations for NP_001156830.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate segment in the 5' UTR, compared to variant 1. Variants 1 and 2 encode the same protein.
      Source sequence(s)
      AL669948
      Consensus CDS
      CCDS24581.1
      UniProtKB/TrEMBL
      Q810Y7
      Related
      ENSMUSP00000104850.2, ENSMUST00000109227.2

    2. NM_178247.3 → NP_839978.1  developmental pluripotency associated 1 precursor

      See identical proteins and their annotated locations for NP_839978.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 encode the same protein.
      Source sequence(s)
      AL669948
      Consensus CDS
      CCDS24581.1
      UniProtKB/TrEMBL
      Q810Y7
      Related
      ENSMUSP00000076416.7, ENSMUST00000077173.13

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      46497837..46520249 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036156789.1 → XP_036012682.1  developmental pluripotency associated 1 isoform X1

      UniProtKB/TrEMBL
      Q3TL00

    2. XM_017314620.2 → XP_017170109.1  developmental pluripotency associated 1 isoform X1

      UniProtKB/TrEMBL
      Q3TL00
    Nucleotide Protein Strain
    Heading Accession and Version

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