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    Defb47 defensin beta 47 [ Mus musculus (house mouse) ]

    Gene ID: 654465, updated on 30-Apr-2024

    Summary

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    Official Symbol
    Defb47provided by MGI
    Official Full Name
    defensin beta 47provided by MGI
    Primary source
    MGI:MGI:3644478
    See related
    Ensembl:ENSMUSG00000075573 AllianceGenome:MGI:3644478
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Defb41; EG654465
    Summary
    Predicted to enable CCR6 chemokine receptor binding activity and chemoattractant activity. Predicted to be involved in cell chemotaxis and defense response to bacterium. Predicted to be located in cytosol. Predicted to be active in extracellular space. Is expressed in ductus deferens; prostate gland; and testis. Orthologous to human DEFB130A (defensin beta 130A) and DEFB130B (defensin beta 130B). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Restricted expression toward genital fat pad adult (RPKM 298.3) See more
    Orthologs
    human all
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    Genomic context

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    See Defb47 in Genome Data Viewer
    Location:
    14 D1; 14 33.23 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (63229824..63238629)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (62992375..63001180)

    Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene deubiquitinating enzyme 1 pseudogene Neighboring gene defensin beta 48 Neighboring gene defensin beta 43 Neighboring gene nuclear undecaprenyl pyrophosphate synthase 1 homolog pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Cross-species analysis of the mammalian beta-defensin gene family: presence of syntenic gene clusters and preferential expression in the male reproductive tract. Patil AA, et al. Physiol Genomics, 2005 Sep 21. PMID 16033865
    2. Manual annotation and analysis of the defensin gene cluster in the C57BL/6J mouse reference genome. Amid C, et al. BMC Genomics, 2009 Dec 15. PMID 20003482, Free PMC Article
    3. The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data. Koscielny G, et al. Nucleic Acids Res, 2014 Jan. PMID 24194600, Free PMC Article
    4. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article
    5. Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Zambrowicz BP, et al. Proc Natl Acad Sci U S A, 2003 Nov 25. PMID 14610273, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (2) 

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables CCR6 chemokine receptor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables chemoattractant activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in cell chemotaxis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in defense response to bacterium IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    beta-defensin 130B
    Names
    defensin beta 41

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001039125.2 → NP_001034214.1  beta-defensin 130B precursor

      See identical proteins and their annotated locations for NP_001034214.1

      Status: VALIDATED

      Source sequence(s)
      BC132604
      Consensus CDS
      CCDS36945.1
      UniProtKB/TrEMBL
      Q30KN1
      Related
      ENSMUSP00000098061.4, ENSMUST00000100492.5

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000080.7 Reference GRCm39 C57BL/6J

      Range
      63229824..63238629
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030247915.1 → XP_030103775.1  beta-defensin 130B isoform X1

      UniProtKB/TrEMBL
      Q30KN1

    2. XM_030247916.1 → XP_030103776.1  beta-defensin 130B isoform X1

      UniProtKB/TrEMBL
      Q30KN1

    3. XM_017316118.2 → XP_017171607.1  beta-defensin 130B isoform X1

      UniProtKB/TrEMBL
      Q30KN1
    Nucleotide Protein Strain
    Heading Accession and Version

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