U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    Fam131b family with sequence similarity 131, member B [ Mus musculus (house mouse) ]

    Gene ID: 76156, updated on 2-Nov-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    Fam131bprovided by MGI
    Official Full Name
    family with sequence similarity 131, member Bprovided by MGI
    Primary source
    MGI:MGI:1923406
    See related
    Ensembl:ENSMUSG00000029861 AllianceGenome:MGI:1923406
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    6330503C03Rik; 6530406I18Rik
    Summary
    Predicted to be located in cytosol and nucleoplasm. Orthologous to human FAM131B (family with sequence similarity 131 member B). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in cerebellum adult (RPKM 27.0), frontal lobe adult (RPKM 21.6) and 6 other tissues See more
    Orthologs
    human all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See Fam131b in Genome Data Viewer
    Location:
    6 B2.1; 6 20.6 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (42292239..42301574, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (42315305..42324640, complement)

    Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene CapStarr-seq enhancer MGSCv37_chr6:42214909-42215092 Neighboring gene caspase 2 Neighboring gene chloride channel, voltage-sensitive 1 Neighboring gene predicted gene, 38797 Neighboring gene CapStarr-seq enhancer MGSCv37_chr6:42293816-42293969 Neighboring gene predicted gene, 24611 Neighboring gene zyxin Neighboring gene Eph receptor A1

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Expression

    Go to the top of the page Help
    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Proteomic analysis of in vivo phosphorylated synaptic proteins. Collins MO, et al. J Biol Chem, 2005 Feb 18. PMID 15572359
    2. Impaired OTUD7A-dependent Ankyrin regulation mediates neuronal dysfunction in mouse and human models of the 15q13.3 microdeletion syndrome. Unda BK, et al. Mol Psychiatry, 2023 Apr. PMID 36604605, Free PMC Article
    3. Comprehensive identification of phosphorylation sites in postsynaptic density preparations. Trinidad JC, et al. Mol Cell Proteomics, 2006 May. PMID 16452087
    4. Identification of new ciliary signaling pathways in the brain and insights into neurological disorders. Loukil A, et al. bioRxiv, 2023 Dec 21. PMID 38187761, Free PMC Article
    5. Neuron-specific protein network mapping of autism risk genes identifies shared biological mechanisms and disease-relevant pathologies. Murtaza N, et al. Cell Rep, 2022 Nov 22. PMID 36417873

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

    Go to the top of the page Help

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Component Evidence Code Pubs
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    protein FAM131B

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001113327.2 → NP_001106798.1  protein FAM131B isoform b

      See identical proteins and their annotated locations for NP_001106798.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (b) lacks an alternate in-frame exon in the 5' coding region, compared to variant a. It encodes isoform b, which lacks an internal segment and is shorter, compared to isoform a.
      Source sequence(s)
      AK163654, BB339978, BY260739
      Consensus CDS
      CCDS51758.1
      UniProtKB/TrEMBL
      A4FUR1
      Related
      ENSMUSP00000031891.9, ENSMUST00000031891.15
      Conserved Domains (1) summary
      pfam15010
      Location:55 → 341
      FAM131; Putative cell signalling

    2. NM_001286584.1 → NP_001273513.1  protein FAM131B isoform c

      See identical proteins and their annotated locations for NP_001273513.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (c) uses an alternate splice site in the 5' terminal exon and initiates translation at a downstream start codon, compared to variant a. It encodes isoform c, which is shorter at the N-terminus, compared to isoform a.
      Source sequence(s)
      AK158869, BB339978, BY260739
      Consensus CDS
      CCDS71759.1
      UniProtKB/Swiss-Prot
      Q3TQE4, Q3TY60, Q9D390
      UniProtKB/TrEMBL
      A4FUR1
      Related
      ENSMUSP00000093670.4, ENSMUST00000095974.4
      Conserved Domains (1) summary
      pfam15010
      Location:39 → 325
      FAM131; Putative cell signalling

    3. NM_029528.5 → NP_083804.3  protein FAM131B isoform a

      Status: VALIDATED

      Description
      Transcript Variant: This variant (a) represents the longest transcript and encodes the longest isoform (a).
      Source sequence(s)
      AK047763, AK163654, BB339978, BY260739
      Consensus CDS
      CCDS39472.2
      UniProtKB/TrEMBL
      A4FUR1, E9Q8P8
      Related
      ENSMUSP00000116779.2, ENSMUST00000143278.8
      Conserved Domains (1) summary
      pfam15010
      Location:67 → 353
      FAM131; Putative cell signalling

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000072.7 Reference GRCm39 C57BL/6J

      Range
      42292239..42301574 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006506730.5 → XP_006506793.1  protein FAM131B isoform X1

      UniProtKB/TrEMBL
      A4FUR1
      Conserved Domains (1) summary
      pfam15010
      Location:68 → 354
      FAM131; Putative cell signalling
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q3TY60.1 GenPept UniProtKB/Swiss-Prot:Q3TY60

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials
    Tools