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    Wscd2 WSC domain containing 2 [ Mus musculus (house mouse) ]

    Gene ID: 320916, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Wscd2provided by MGI
    Official Full Name
    WSC domain containing 2provided by MGI
    Primary source
    MGI:MGI:2445030
    See related
    Ensembl:ENSMUSG00000063430 AllianceGenome:MGI:2445030
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Gm450; 4933413A10Rik; C530024P05Rik
    Summary
    Enables sulfotransferase activity. Located in Golgi membrane. Is expressed in inner ear; skeleton; tarsus; and telencephalon mantle layer. Orthologous to human WSCD2 (WSC domain containing 2). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in cerebellum adult (RPKM 22.8), colon adult (RPKM 8.6) and 21 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Wscd2 in Genome Data Viewer
    Location:
    5 F; 5 55.55 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (113636976..113727786)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (113489110..113589725)

    Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_14038 Neighboring gene activator of yeast meiotic promoters 1 Neighboring gene STARR-seq mESC enhancer starr_14039 Neighboring gene STARR-seq mESC enhancer starr_14040 Neighboring gene predicted gene, 30812 Neighboring gene STARR-seq mESC enhancer starr_14042 Neighboring gene predicted gene, 52822 Neighboring gene STARR-seq mESC enhancer starr_14044 Neighboring gene STARR-seq mESC enhancer starr_14048 Neighboring gene STARR-seq mESC enhancer starr_14049 Neighboring gene chemerin chemokine-like receptor 1 Neighboring gene predicted gene 15736 Neighboring gene predicted gene, 52823

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Sulfation of sialic acid is ubiquitous and essential for vertebrate development. Ertunc N, et al. Sci Rep, 2022 Jul 21. PMID 35864127, Free PMC Article
    2. Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. Okazaki N, et al. DNA Res, 2004 Jun 30. PMID 15368895
    3. Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. Hansen GM, et al. Genome Res, 2008 Oct. PMID 18799693, Free PMC Article
    4. Genetic determinants of micronucleus formation in vivo. Adams DJ, et al. Nature, 2024 Mar. PMID 38355793, Free PMC Article
    5. Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Zambrowicz BP, et al. Proc Natl Acad Sci U S A, 2003 Nov 25. PMID 14610273, Free PMC Article

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (4) 

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    enables sulfotransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  

    General protein information

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    Preferred Names
    sialate:O-sulfotransferase 2
    Names
    WSC domain-containing protein 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_177292.3 → NP_796266.2  sialate:O-sulfotransferase 2

      See identical proteins and their annotated locations for NP_796266.2

      Status: VALIDATED

      Source sequence(s)
      BC096526
      Consensus CDS
      CCDS19550.2
      UniProtKB/Swiss-Prot
      D4PHA7, Q69ZZ2, Q8C7Q3
      Related
      ENSMUSP00000092021.4, ENSMUST00000094452.4
      Conserved Domains (2) summary
      smart00321
      Location:134 → 225
      WSC; present in yeast cell wall integrity and stress response component proteins
      cl21551
      Location:421 → 513
      Sulfotransfer_3; Sulfotransferase family

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000071.7 Reference GRCm39 C57BL/6J

      Range
      113636976..113727786
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017320928.2 → XP_017176417.1  sialate:O-sulfotransferase 2 isoform X1

      UniProtKB/Swiss-Prot
      D4PHA7, Q69ZZ2, Q8C7Q3
      Conserved Domains (2) summary
      smart00321
      Location:134 → 225
      WSC; present in yeast cell wall integrity and stress response component proteins
      cl21551
      Location:421 → 513
      Sulfotransfer_3; Sulfotransferase family

    2. XM_036165221.1 → XP_036021114.1  sialate:O-sulfotransferase 2 isoform X3

      Conserved Domains (2) summary
      smart00321
      Location:1 → 72
      WSC; present in yeast cell wall integrity and stress response component proteins
      cl21551
      Location:163 → 255
      Sulfotransfer_3; Sulfotransferase family

    3. XM_030254582.2 → XP_030110442.1  sialate:O-sulfotransferase 2 isoform X2

      Conserved Domains (3) summary
      smart00321
      Location:34 → 128
      WSC; present in yeast cell wall integrity and stress response component proteins
      cl02568
      Location:1 → 23
      WSC; WSC domain
      cl21551
      Location:219 → 311
      Sulfotransfer_3; Sulfotransferase family
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    D4PHA7.1 GenPept UniProtKB/Swiss-Prot:D4PHA7

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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