Lilrb4b leukocyte immunoglobulin-like receptor, subfamily B, member 4B [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Lilrb4bprovided by MGI
Official Full Name: leukocyte immunoglobulin-like receptor, subfamily B, member 4Bprovided by MGI
Primary source: MGI:MGI:102702
See related: Ensembl:ENSMUSG00000112023 AllianceGenome:MGI:102702
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: gp49; Gp49a; Lilr4b
Summary: Predicted to enable several functions, including apolipoprotein binding activity; fibronectin binding activity; and transmembrane receptor protein tyrosine kinase inhibitor activity. Involved in mast cell activation. Located in cell surface. Orthologous to human LILRB4 (leukocyte immunoglobulin like receptor B4). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Broad expression in subcutaneous fat pad adult (RPKM 4.8), mammary gland adult (RPKM 4.7) and 21 other tissues See more
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Genomic context

Location:: 10 B3; 10 25.5 cM

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	10	NC_000076.7 (51356757..51362417)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	10	NC_000076.6 (51480612..51486329)

Chromosome 10 - NC_000076.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

LILRB4/gp49B Co-Localizes with Integrin via Fibronectin at Focal Adhesion Sites on Mast Cells.
Title: LILRB4/gp49B Co-Localizes with Integrin via Fibronectin at Focal Adhesion Sites on Mast Cells.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)

General gene information

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Markers

NoName (e-PCR)
- UniSTS:236349

U05265 (e-PCR)
- UniSTS:159979

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables apolipoprotein binding	ISO Inferred from Sequence Orthology more info
enables fibronectin binding	ISO Inferred from Sequence Orthology more info
enables inhibitory MHC class I receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein phosphatase binding	ISO Inferred from Sequence Orthology more info
enables signaling receptor inhibitor activity	ISO Inferred from Sequence Orthology more info
enables transmembrane receptor protein tyrosine kinase inhibitor activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in Fc receptor mediated inhibitory signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in cytokine-mediated signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in immune response-regulating signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in mast cell activation	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of IP-10 production	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of MAPK cascade	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of T cell costimulation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of T cell cytokine production	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of T cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of T cell receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of activated T cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of canonical NF-kappaB signal transduction	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of chemokine production	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cytokine production involved in inflammatory response	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cytotoxic T cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of interleukin-1 beta production	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of interleukin-10 production	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of interleukin-2 production	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of interleukin-5 production	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of interleukin-6 production	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of miRNA transcription	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of monocyte activation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of osteoclast differentiation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of protein localization to nucleus	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of protein tyrosine kinase activity	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of signaling receptor activity	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of tumor necrosis factor production	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of type II interferon production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of CD8-positive, alpha-beta T cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of T cell anergy	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of regulatory T cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in receptor internalization	ISO Inferred from Sequence Orthology more info
involved_in tolerance induction	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cell surface	IDA Inferred from Direct Assay more info	PubMed
located_in cell surface	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: leukocyte immunoglobulin-like receptor subfamily B member 4B

Names: glycoprotein 49 A; mast cell surface glycoprotein Gp49A

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001291892.2 → NP_001278821.1 leukocyte immunoglobulin-like receptor subfamily B member 4B isoform 2

Status: VALIDATED

Source sequence(s)

AC153530

Conserved Domains (1) summary

cl11960
Location:37 → 131

Ig; Immunoglobulin domain
NM_001291893.2 → NP_001278822.1 leukocyte immunoglobulin-like receptor subfamily B member 4B isoform 3 precursor

Status: VALIDATED

Source sequence(s)

AC153530

Consensus CDS

CCDS88004.1

UniProtKB/TrEMBL

A0A1W2P6F1, A0A1W2P7F3

Related

ENSMUSP00000151625.2, ENSMUST00000219661.2

Conserved Domains (1) summary

cl11960
Location:29 → 123

Ig; Immunoglobulin domain
NM_001419401.1 → NP_001406330.1 leukocyte immunoglobulin-like receptor subfamily B member 4B isoform 4

Status: VALIDATED

Source sequence(s)

AC153530
NM_008147.3 → NP_032173.1 leukocyte immunoglobulin-like receptor subfamily B member 4B isoform 1 precursor

Status: VALIDATED

Source sequence(s)

AC153530

Consensus CDS

CCDS23831.1

UniProtKB/Swiss-Prot

Q549E3, Q61450

UniProtKB/TrEMBL

A0A1W2P7X1

Related

ENSMUSP00000099958.4, ENSMUST00000102894.6

Conserved Domains (1) summary

cl11960
Location:124 → 218

Ig; Immunoglobulin domain