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    Cdc6 cell division cycle 6 [ Mus musculus (house mouse) ]

    Gene ID: 23834, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Cdc6provided by MGI
    Official Full Name
    cell division cycle 6provided by MGI
    Primary source
    MGI:MGI:1345150
    See related
    Ensembl:ENSMUSG00000017499 AllianceGenome:MGI:1345150
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    CDC18L; p62(cdc6)
    Summary
    Enables chromatin binding activity. Predicted to be involved in DNA replication initiation; positive regulation of fibroblast proliferation; and regulation of cell cycle process. Located in cytoplasm and spindle. Is expressed in central nervous system; heart; and retina. Human ortholog(s) of this gene implicated in Meier-Gorlin syndrome 5. Orthologous to human CDC6 (cell division cycle 6). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in liver E14 (RPKM 13.4), liver E14.5 (RPKM 11.7) and 10 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Cdc6 in Genome Data Viewer
    Location:
    11 62.74 cM; 11 D
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (98798627..98814768)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (98907709..98923942)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene Rap guanine nucleotide exchange factor (GEF)-like 1 Neighboring gene STARR-positive B cell enhancer ABC_E9145 Neighboring gene WAS/WASL interacting protein family, member 2 Neighboring gene VISTA enhancer mm1323 Neighboring gene STARR-positive B cell enhancer ABC_E203 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:98803426-98803613 Neighboring gene retinoic acid receptor, alpha Neighboring gene STARR-positive B cell enhancer ABC_E9373 Neighboring gene predicted gene, 46294 Neighboring gene predicted gene, 22061

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Identification and characterization of a mouse homolog to yeast Cdc6p. Berger C, et al. Cytogenet Cell Genet, 1999. PMID 10575231
    2. CDC6 requirement for spindle formation during maturation of mouse oocytes. Anger M, et al. Biol Reprod, 2005 Jan. PMID 15385409
    3. CDC6 regulates both G2/M transition and metaphase-to-anaphase transition during the first meiosis of mouse oocytes. Yi ZY, et al. J Cell Physiol, 2020 Jul. PMID 31984513
    4. Cdc6 protein obstructs apoptosome assembly and consequent cell death by forming stable complexes with activated Apaf-1 molecules. Niimi S, et al. J Biol Chem, 2012 May 25. PMID 22493447, Free PMC Article
    5. Cell cycle-regulated expression of mammalian CDC6 is dependent on E2F. Hateboer G, et al. Mol Cell Biol, 1998 Nov. PMID 9774682, Free PMC Article

    See all (50) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Novel Role of Prereplication Complex Component Cell Division Cycle 6 in Retinal Neovascularization.
      Title: Novel Role of Prereplication Complex Component Cell Division Cycle 6 in Retinal Neovascularization.
    2. CDC6 regulates both G2/M transition and metaphase-to-anaphase transition during the first meiosis of mouse oocytes.
      Title: CDC6 regulates both G2/M transition and metaphase-to-anaphase transition during the first meiosis of mouse oocytes.
    3. Dele and Cdc6 G-quadruplex formation is significant in the transcriptional regulation. Dele and Cdc6 G-quadruplex DNA alone possess enhancer and promotor function.
      Title: Identification of G-quadruplex structures that possess transcriptional regulating functions in the Dele and Cdc6 CpG islands.
    4. CDK1 activation proceeds with concomitant inhibition by CDC6, which tunes the timing of the M-phase entry during the embryonic cell cycle
      Title: CDC6 controls dynamics of the first embryonic M-phase entry and progression via CDK1 inhibition.
    5. Cdc6 continued to block apoptosome assembly induced by a non-cytochrome c or some other mechanism, suppressing seemingly unintended apoptosis when promoting cell proliferation
      Title: Cdc6 protein obstructs apoptosome assembly and consequent cell death by forming stable complexes with activated Apaf-1 molecules.
    6. show that MyoD can occupy an E-box within the promoter of Cdc6 and that this association, along with E2F3a, is required for its activity.
      Title: Activation of Cdc6 by MyoD is associated with the expansion of quiescent myogenic satellite cells.
    7. hCdt1 and hCdc6 expression promote malignant behavior
      Title: Deregulated overexpression of hCdt1 and hCdc6 promotes malignant behavior.
    8. CDC6 is essential for spindle formation in mouse oocytes
      Title: CDC6 requirement for spindle formation during maturation of mouse oocytes.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (1) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA replication origin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables chromatin binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables kinase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA replication initiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in DNA replication initiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cell division IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mitotic DNA replication checkpoint signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of chromosome segregation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of cytokinesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of fibroblast proliferation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of mitotic metaphase/anaphase transition ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in intercellular bridge ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitotic spindle ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in spindle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in spindle midzone ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in spindle pole ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    cell division control protein 6 homolog
    Names
    CDC6-related protein
    cell division cycle 6 homolog

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001025779.2 → NP_001020950.1  cell division control protein 6 homolog isoform b

      See identical proteins and their annotated locations for NP_001020950.1

      Status: VALIDATED

      Source sequence(s)
      AL591067, BC052434
      Consensus CDS
      CCDS25368.1
      UniProtKB/Swiss-Prot
      O89033, Q3TMD0, Q8C3S5, Q9CZT0
      Related
      ENSMUSP00000090382.7, ENSMUST00000092706.13
      Conserved Domains (3) summary
      smart01074
      Location:467 → 547
      Cdc6_C; CDC6, C terminal
      COG1474
      Location:170 → 547
      CDC6; Cdc6-related protein, AAA superfamily ATPase [Replication, recombination and repair]
      pfam13191
      Location:173 → 314
      AAA_16; AAA ATPase domain

    2. NM_001362735.1 → NP_001349664.1  cell division control protein 6 homolog isoform c

      Status: VALIDATED

      Source sequence(s)
      AL591067
      Conserved Domains (1) summary
      COG1474
      Location:170 → 546
      CDC6; Cdc6-related protein, AAA superfamily ATPase [Replication, recombination and repair]

    3. NM_011799.2 → NP_035929.1  cell division control protein 6 homolog isoform a

      See identical proteins and their annotated locations for NP_035929.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (a).
      Source sequence(s)
      AJ223087, AL591067
      Consensus CDS
      CCDS25367.1
      UniProtKB/TrEMBL
      A0A0R4J145
      Related
      ENSMUSP00000091469.3, ENSMUST00000093937.3
      Conserved Domains (3) summary
      smart01074
      Location:494 → 574
      Cdc6_C; CDC6, C terminal
      COG1474
      Location:197 → 574
      CDC6; Cdc6-related protein, AAA superfamily ATPase [Replication, recombination and repair]
      pfam13191
      Location:200 → 341
      AAA_16; AAA ATPase domain

    RNA

    1. NR_156128.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AK162669, AL591067, CO041455
      Related
      ENSMUST00000133779.9

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      98798627..98814768
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O89033.2 GenPept UniProtKB/Swiss-Prot:O89033

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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