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    St6galnac1 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1 [ Mus musculus (house mouse) ]

    Gene ID: 20445, updated on 2-Nov-2024

    Summary

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    Official Symbol
    St6galnac1provided by MGI
    Official Full Name
    ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1provided by MGI
    Primary source
    MGI:MGI:1341826
    See related
    Ensembl:ENSMUSG00000009588 AllianceGenome:MGI:1341826
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Siat7a
    Summary
    Enables alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase activity. Involved in host-mediated regulation of intestinal microbiota composition. Acts upstream of or within oligosaccharide biosynthetic process. Predicted to be located in membrane. Predicted to be active in Golgi membrane. Is expressed in colon; mammary gland; and salivary gland. Used to study inflammatory bowel disease. Orthologous to human ST6GALNAC1 (ST6 N-acetylgalactosaminide alpha-2,6-sialyltransferase 1). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in colon adult (RPKM 3.7), thymus adult (RPKM 2.2) and 8 other tissues See more
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    Genomic context

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    See St6galnac1 in Genome Data Viewer
    Location:
    11 E2; 11 81.49 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (116655851..116666333, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (116765025..116775507, complement)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene predicted gene 11735 Neighboring gene cDNA sequence BC018473 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:116644149-116644366 Neighboring gene matrix-remodelling associated 7 Neighboring gene STARR-seq mESC enhancer starr_31225 Neighboring gene STARR-positive B cell enhancer ABC_E7102 Neighboring gene jumonji domain containing 6 Neighboring gene methyltransferase like 23

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Enhancement of metastatic ability by ectopic expression of ST6GalNAcI on a gastric cancer cell line in a mouse model. Ozaki H, et al. Clin Exp Metastasis, 2012 Mar. PMID 22228572, Free PMC Article
    2. Molecular cloning and genomic analysis of mouse GalNAc alpha2, 6-sialyltransferase (ST6GalNAc I). Kurosawa N, et al. J Biochem, 2000 May. PMID 10788794
    3. Representational difference analysis in a lupus-prone mouse strain results in the identification of an unstable region of the genome on chromosome 11. Fu G, et al. Nucleic Acids Res, 2002 Mar 15. PMID 11884638, Free PMC Article
    4. Expression of sialyl-Tn epitopes on beta1 integrin alters epithelial cell phenotype, proliferation and haptotaxis. Clément M, et al. J Cell Sci, 2004 Oct 1. PMID 15383613
    5. Mucus sialylation determines intestinal host-commensal homeostasis. Yao Y, et al. Cell, 2022 Mar 31. PMID 35303419, Free PMC Article

    See all (21) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Results suggest a role of ST6GalNAc I in promoting the growth and invasion of hepatocarcinoma cells through regulating PI3K/AKT/NF-kappa B signaling, and ST6GalNAc I might be a marker for the prognosis and therapy of hepatocarcinoma.
      Title: Silencing of ST6GalNAc I suppresses the proliferation, migration and invasion of hepatocarcinoma cells through PI3K/AKT/NF-κB pathway.
    2. It was confirmed that MUC1 carries sialyl Tn also in human advanced gastric cancer tissues
      Title: Enhancement of metastatic ability by ectopic expression of ST6GalNAcI on a gastric cancer cell line in a mouse model.
    3. ST6GalNAc I has a role in O-glycosylation of the integrin beta1 chain and integrin beta 1-mediated signalling
      Title: Expression of sialyl-Tn epitopes on beta1 integrin alters epithelial cell phenotype, proliferation and haptotaxis.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within ganglioside biosynthetic process TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in host-mediated regulation of intestinal microbiota composition IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in modulation by host of symbiont process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in oligosaccharide biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within oligosaccharide biosynthetic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in protein glycosylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein glycosylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein glycosylation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    is_active_in Golgi membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in Golgi membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1
    Names
    SIAT7-A
    ST6GalNAc I
    ST6GalNAcI
    sialyltransferase 7 ((alpha-N-acetylneuraminyl 2,3-beta-galactosyl-1,3)-N-acetyl galactosaminde alpha-2,6-sialyltransferase) A
    sialyltransferase 7A
    NP_035501.2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_011371.2 → NP_035501.2  alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1

      See identical proteins and their annotated locations for NP_035501.2

      Status: VALIDATED

      Source sequence(s)
      AL645542, BE847090, Y11274
      Consensus CDS
      CCDS36380.1
      UniProtKB/Swiss-Prot
      A2AA23, Q9JJP5, Q9QZ39
      UniProtKB/TrEMBL
      B7ZNQ3
      Related
      ENSMUSP00000009732.8, ENSMUST00000009732.8
      Conserved Domains (2) summary
      pfam00777
      Location:231 → 517
      Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)
      pfam05466
      Location:45 → 169
      BASP1; Brain acid soluble protein 1 (BASP1 protein)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      116655851..116666333 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9QZ39.2 GenPept UniProtKB/Swiss-Prot:Q9QZ39

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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