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    Helq helicase, POLQ-like [ Rattus norvegicus (Norway rat) ]

    Gene ID: 360912, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Helqprovided by RGD
    Official Full Name
    helicase, POLQ-likeprovided by RGD
    Primary source
    RGD:1560216
    See related
    EnsemblRapid:ENSRNOG00000002181 AllianceGenome:RGD:1560216
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Hel308
    Summary
    Predicted to enable single-stranded 3'-5' DNA helicase activity. Predicted to be involved in double-strand break repair and positive regulation of double-strand break repair via homologous recombination. Predicted to be active in nucleus and site of DNA damage. Orthologous to human HELQ (helicase, POLQ like). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Thymus (RPKM 48.2), Spleen (RPKM 41.6) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Helq in Genome Data Viewer
    Location:
    14p22
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 14 NC_086032.1 (9122978..9167310)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 14 NC_051349.1 (8818582..8862926)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 14 NC_005113.4 (10446981..10491042)

    Chromosome 14 - NC_086032.1Genomic Context describing neighboring genes Neighboring gene abraxas 1, BRCA1 A complex subunit Neighboring gene mitochondrial ribosomal protein S18C Neighboring gene uncharacterized LOC134481712 Neighboring gene uncharacterized LOC108352710 Neighboring gene heparanase Neighboring gene peptidylprolyl isomerase D, pseudogene 10

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. DNA polymerase POLN participates in cross-link repair and homologous recombination. Moldovan GL, et al. Mol Cell Biol, 2010 Feb. PMID 19995904, Free PMC Article
    2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables single-stranded 3'-5' DNA helicase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA double-strand break processing involved in repair via single-strand annealing ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in DNA duplex unwinding IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in double-strand break repair via alternative nonhomologous end joining ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in double-strand break repair via homologous recombination ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in double-strand break repair via synthesis-dependent strand annealing ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of double-strand break repair via homologous recombination ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in site of DNA damage ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    helicase POLQ-like
    Names
    DNA helicase HEL308
    NP_001014156.2
    XP_008768262.1
    XP_008768263.1
    XP_038948085.1
    XP_063129394.1
    XP_063129396.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001014134.2 → NP_001014156.2  helicase POLQ-like

      See identical proteins and their annotated locations for NP_001014156.2

      Status: VALIDATED

      Source sequence(s)
      CH474022
      UniProtKB/TrEMBL
      A6K5Y2, E9PT19
      Related
      ENSRNOP00000002974.5, ENSRNOT00000002974.8
      Conserved Domains (4) summary
      smart00490
      Location:589 → 667
      HELICc; helicase superfamily c-terminal domain
      PRK02362
      Location:273 → 1020
      PRK02362; ski2-like helicase; Provisional
      pfam00270
      Location:300 → 461
      DEAD; DEAD/DEAH box helicase
      pfam14520
      Location:967 → 1020
      HHH_5; Helix-hairpin-helix domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086032.1 Reference GRCr8

      Range
      9122978..9167310
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063273324.1 → XP_063129394.1  helicase POLQ-like isoform X1

      Related
      ENSRNOP00000083721.2, ENSRNOT00000113418.2

    2. XM_039092157.2 → XP_038948085.1  helicase POLQ-like isoform X2

      Related
      ENSRNOP00000104289.1, ENSRNOT00000122711.1
      Conserved Domains (2) summary
      PRK02362
      Location:273 → 962
      PRK02362; ATP-dependent DNA helicase
      cd18026
      Location:274 → 476
      DEXHc_POLQ-like; DEXH-box helicase domain of DNA polymerase theta

    3. XM_063273326.1 → XP_063129396.1  helicase POLQ-like isoform X4

    4. XM_008770040.3 → XP_008768262.1  helicase POLQ-like isoform X3

      See identical proteins and their annotated locations for XP_008768262.1

      UniProtKB/TrEMBL
      A6K5Y5
      Conserved Domains (4) summary
      smart00490
      Location:238 → 316
      HELICc; helicase superfamily c-terminal domain
      PRK02362
      Location:39 → 669
      PRK02362; ski2-like helicase; Provisional
      pfam14520
      Location:616 → 669
      HHH_5; Helix-hairpin-helix domain
      cl21455
      Location:1 → 110
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

    5. XM_008770041.3 → XP_008768263.1  helicase POLQ-like isoform X5

      Conserved Domains (3) summary
      smart00490
      Location:90 → 168
      HELICc; helicase superfamily c-terminal domain
      PRK02362
      Location:15 → 521
      PRK02362; ski2-like helicase; Provisional
      pfam14520
      Location:468 → 521
      HHH_5; Helix-hairpin-helix domain
    Nucleotide Protein Strain
    Heading Accession and Version

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