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    Golm1 golgi membrane protein 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 680692, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Golm1provided by RGD
    Official Full Name
    golgi membrane protein 1provided by RGD
    Primary source
    RGD:1589384
    See related
    EnsemblRapid:ENSRNOG00000018400 AllianceGenome:RGD:1589384
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to act upstream of or within nucleus organization and regulation of lipid metabolic process. Predicted to be located in membrane. Predicted to be active in Golgi apparatus. Orthologous to human GOLM1 (golgi membrane protein 1). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Heart (RPKM 192.6), Kidney (RPKM 163.6) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Golm1 in Genome Data Viewer
    Location:
    17p14
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 17 NC_086035.1 (4996978..5049278)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 17 NC_051352.1 (4995925..5044329)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 17 NC_005116.4 (5373095..5411186)

    Chromosome 17 - NC_086035.1Genomic Context describing neighboring genes Neighboring gene SPATA31 subfamily D, member 3 Neighboring gene similar to human chromosome 9 open reading frame 153 Neighboring gene uncharacterized LOC134482661 Neighboring gene N(alpha)-acetyltransferase 35, NatC auxiliary subunit Neighboring gene serine/arginine repetitive matrix protein 3-like Neighboring gene ATP/GTP binding carboxypeptidase 1 Neighboring gene uncharacterized LOC134482764

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. External validation of genetically predicted protein biomarkers for pancreatic cancer risk using aptamer-based plasma levels: A prospective analysis in the Atherosclerosis Risk in Communities Study. Liu T, et al. Int J Cancer, 2023 Sep 15. PMID 37338014, Free PMC Article
    2. Plasma proteomics of SARS-CoV-2 infection and severity reveals impact on Alzheimer and coronary disease pathways. Wang L, et al. medRxiv, 2022 Jul 25. PMID 35923315, Free PMC Article
    3. Serological AFP/Golgi protein 73 could be a new diagnostic parameter of hepatic diseases. Tian L, et al. Int J Cancer, 2011 Oct 15. PMID 21140449
    4. Golgi Protein 73 Promotes LPS-Induced Cardiac Dysfunction via Mediating Myocardial Apoptosis and Autophagy. Xing Y, et al. J Cardiovasc Pharmacol, 2024 Jan 1. PMID 37755435
    5. GOLM1 Stimulation of Glutamine Metabolism Promotes Osteoporosis via Inhibiting Osteogenic Differentiation of BMSCs. Shen G, et al. Cell Physiol Biochem, 2018. PMID 30396165

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Golgi Protein 73 Promotes LPS-Induced Cardiac Dysfunction via Mediating Myocardial Apoptosis and Autophagy.
      Title: Golgi Protein 73 Promotes LPS-Induced Cardiac Dysfunction via Mediating Myocardial Apoptosis and Autophagy.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    acts_upstream_of_or_within nucleus organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within regulation of lipid metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in Golgi apparatus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Golgi membrane protein 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001427411.2 → NP_001414340.1  Golgi membrane protein 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000017
      UniProtKB/TrEMBL
      A0A8I5ZPY1
      Related
      ENSRNOP00000110202.1, ENSRNOT00000128517.1

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086035.1 Reference GRCr8

      Range
      4996978..5049278
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039096415.2 → XP_038952343.2  Golgi membrane protein 1 isoform X1

      Related
      ENSRNOP00000103374.1, ENSRNOT00000159656.1

    2. XM_039096416.2 → XP_038952344.1  Golgi membrane protein 1 isoform X3

      UniProtKB/TrEMBL
      A0A8I5ZPY1, D4AEL2
      Conserved Domains (1) summary
      COG1196
      Location:41 → 218
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

    3. XM_039096417.2 → XP_038952345.1  Golgi membrane protein 1 isoform X3

      UniProtKB/TrEMBL
      A0A8I5ZPY1, D4AEL2
      Conserved Domains (1) summary
      COG1196
      Location:41 → 218
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

    4. XM_063276736.1 → XP_063132806.1  Golgi membrane protein 1 isoform X2

      Related
      ENSRNOP00000080545.2, ENSRNOT00000115015.2

    RNA

    1. XR_005495817.2 RNA Sequence

    2. XR_005495818.2 RNA Sequence

    3. XR_010058935.1 RNA Sequence

    4. XR_010058934.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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