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    eef-1A.2 Elongation factor 1-alpha [ Caenorhabditis elegans ]

    Gene ID: 181044, updated on 12-Jun-2024

    Summary

    Gene symbol
    eef-1A.2
    Gene description
    Elongation factor 1-alpha
    Locus tag
    CELE_R03G5.1
    See related
    AllianceGenome:WB:WBGene00001169
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable GTP binding activity; GTPase activity; and translation elongation factor activity. Predicted to be involved in translational elongation. Human ortholog(s) of this gene implicated in autosomal dominant non-syndromic intellectual disability 38; developmental and epileptic encephalopathy 33; and ovarian cancer. Orthologous to several human genes including EEF1A1 (eukaryotic translation elongation factor 1 alpha 1) and EEF1A2 (eukaryotic translation elongation factor 1 alpha 2). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

    See eef-1A.2 in Genome Data Viewer
    Location:
    chromosome: X
    Exon count:
    3
    Sequence:
    Chromosome: X; NC_003284.9 (7823654..7825769)

    Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene Dual specificity mitogen-activated protein kinase kinase sek-1 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Sulfatase N-terminal domain-containing protein

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables GTP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables GTPase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables translation elongation factor activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in translational elongation IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    Elongation factor 1-alpha
    NP_509323.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003284.9 Reference assembly

      Range
      7823654..7825769
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_076922.5NP_509323.1  Elongation factor 1-alpha [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_509323.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P53013
      Conserved Domains (4) summary
      PTZ00141
      Location:1461
      PTZ00141; elongation factor 1- alpha; Provisional
      cd01883
      Location:9239
      EF1_alpha; Elongation Factor 1-alpha (EF1-alpha) protein family
      cd03693
      Location:242332
      EF1_alpha_II; Domain II of elongation factor 1-alpha
      cd03705
      Location:335438
      EF1_alpha_III; Domain III of Elongation Factor 1