Fubp1 far upstream element (FUSE) binding protein 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Fubp1provided by MGI
Official Full Name: far upstream element (FUSE) binding protein 1provided by MGI
Primary source: MGI:MGI:1196294
See related: Ensembl:ENSMUSG00000028034 AllianceGenome:MGI:1196294
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: FBP; Fubp; Fubp4; D3Ertd330e; 9530027K12Rik
Summary: Enables RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Acts upstream of or within hematopoietic stem cell proliferation; regulation of transcription by RNA polymerase II; and somatic stem cell division. Is active in synapse. Is expressed in several structures, including central nervous system; gonad; jaw; limb; and sensory organ. Human ortholog(s) of this gene implicated in hepatocellular carcinoma. Orthologous to human FUBP1 (far upstream element binding protein 1). [provided by Alliance of Genome Resources, Oct 2024]
Expression: Broad expression in CNS E11.5 (RPKM 43.8), CNS E14 (RPKM 43.1) and 27 other tissues See more
Orthologs: human all
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Genomic context

Location:: 3 H3; 3 77.05 cM

Exon count:: 21

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	3	NC_000069.7 (151916059..151942467)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	3	NC_000069.6 (152210422..152236830)

Chromosome 3 - NC_000069.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

FUBP1 and FUBP2 enforce distinct epigenetic setpoints for MYC expression in primary single murine cells.
Title: FUBP1 and FUBP2 enforce distinct epigenetic setpoints for MYC expression in primary single murine cells.
Long non-coding RNA small nucleolar RNA host gene 6 aggravates pancreatic cancer through upregulation of far upstream element binding protein 1 by sponging microRNA-26a-5p.
Title: Long non-coding RNA small nucleolar RNA host gene 6 aggravates pancreatic cancer through upregulation of far upstream element binding protein 1 by sponging microRNA-26a-5p.
Fubp1 upregulates the mRNA levels of two hexokinase genes, Hk1 and Hk2. We suggest that Fubp1 contributes to cell survival through supporting lactate-Akt-mTOR axis.
Title: Fubp1 supports the lactate-Akt-mTOR axis through the upregulation of Hk1 and Hk2.
High FUBP1 expression is associated with myeloid leukemia.
Title: The transcriptional regulator FUBP1 influences disease outcome in murine and human myeloid leukemia.
collaborative action between SRRM4 and FUBP1 is necessary for mini-exon splicing of the neurospecific LSD1+8a isoform.
Title: Far Upstream Element-Binding Protein 1 Regulates LSD1 Alternative Splicing to Promote Terminal Differentiation of Neural Progenitors.
FBP helps to hold multiple physiologic processes to close tolerances, at least in part by constraining Myc expression.
Title: Far Upstream Element Binding Protein Plays a Crucial Role in Embryonic Development, Hematopoiesis, and Stabilizing Myc Expression Levels.
Our data establish FUBP1 and its recognition of single-stranded genomic DNA as an important element in the transcriptional regulation of hematopoietic stem cells self-renewal.
Title: Single-Stranded DNA-Binding Transcriptional Regulator FUBP1 Is Essential for Fetal and Adult Hematopoietic Stem Cell Self-Renewal.
Apoptosis-mediated cleavage of FBP1 and its decreased expression in epithelial cells induces cell cycle arrest, which may play an important role in colonic epithelial disruption in colitis.
Title: Role of far upstream element binding protein 1 in colonic epithelial disruption during dextran sulphate sodium-induced murine colitis.
FUBP1 is an authentic substrate of Parkin that might play an important role in development of Parkinson disease pathology along with aminoacyl-tRNA synthetase interacting multifunctional protein type 2
Title: Identification of far upstream element-binding protein-1 as an authentic Parkin substrate.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (4)
Gene trapped (2)
Targeted (1) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Fubp (e-PCR), detects polymorphism
- UniSTS:143147

Fubp (e-PCR), detects polymorphism
- UniSTS:143148

A62227834FB73 (e-PCR)
- UniSTS:229182

FUBP1 (e-PCR)
- UniSTS:503879

UniSTS:234848 (e-PCR)
- UniSTS:234848

RH125594 (e-PCR)
- UniSTS:162408

Fubp1 (e-PCR), detects polymorphism
- UniSTS:479110

RH126972 (e-PCR)
- UniSTS:167356

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables RNA binding	IEA Inferred from Electronic Annotation more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables mRNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within developmental cell growth	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within hematopoietic stem cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of Schwann cell migration	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of gene expression	ISO Inferred from Sequence Orthology more info
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within somatic stem cell division	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
is_active_in synapse	EXP Inferred from Experiment more info	PubMed
is_active_in synapse	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: far upstream element-binding protein 1

Names: FUSE-binding protein 1; far upstream element (FUSE) binding protein 4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001355366.2 → NP_001342295.1 far upstream element-binding protein 1 isoform 1

Status: VALIDATED

Source sequence(s)

AC123075

UniProtKB/TrEMBL

Q3TIS5

Conserved Domains (2) summary

cd00105
Location:295 → 356

KH-I; K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that ...

pfam00013
Location:119 → 183

KH_1; KH domain
NM_001355367.2 → NP_001342296.1 far upstream element-binding protein 1 isoform 2

Status: VALIDATED

Source sequence(s)

AC123075

UniProtKB/TrEMBL

Q3TIS5

Conserved Domains (2) summary

cd00105
Location:294 → 355

KH-I; K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that ...

pfam00013
Location:118 → 182

KH_1; KH domain
NM_001355368.2 → NP_001342297.1 far upstream element-binding protein 1 isoform 3

Status: VALIDATED

Source sequence(s)

AC123075

UniProtKB/TrEMBL

Q3TIS5

Conserved Domains (2) summary

cd00105
Location:295 → 356

KH-I; K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that ...

pfam00013
Location:119 → 183

KH_1; KH domain
NM_001355369.2 → NP_001342298.1 far upstream element-binding protein 1 isoform 4

Status: VALIDATED

Source sequence(s)

AC123075

Consensus CDS

CCDS89708.1

UniProtKB/TrEMBL

A0A0G2JFY5, Q3TIS5

Related

ENSMUSP00000143354.2, ENSMUST00000200524.5

Conserved Domains (2) summary

cd00105
Location:274 → 335

KH-I; K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that ...

pfam00013
Location:98 → 162

KH_1; KH domain
NM_001355370.2 → NP_001342299.1 far upstream element-binding protein 1 isoform 5

Status: VALIDATED

Source sequence(s)

AC123075

UniProtKB/TrEMBL

Q3TIS5

Conserved Domains (2) summary

cd00105
Location:273 → 334

KH-I; K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that ...

pfam00013
Location:97 → 161

KH_1; KH domain
NM_001355371.2 → NP_001342300.1 far upstream element-binding protein 1 isoform 6

Status: VALIDATED

Source sequence(s)

AC123075

Consensus CDS

CCDS89707.1

UniProtKB/Swiss-Prot

Q8C0Y8, Q91WJ8

UniProtKB/TrEMBL

Q3TIS5

Related

ENSMUSP00000143101.2, ENSMUST00000196739.5

Conserved Domains (2) summary

cd00105
Location:274 → 335

KH-I; K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that ...

pfam00013
Location:98 → 162

KH_1; KH domain
NM_001355372.2 → NP_001342301.1 far upstream element-binding protein 1 isoform 7

Status: VALIDATED

Source sequence(s)

AC123075

Consensus CDS

CCDS89709.1

UniProtKB/TrEMBL

A0A0G2JGW9, Q3TIS5

Related

ENSMUSP00000143729.2, ENSMUST00000196695.5

Conserved Domains (2) summary

cd00105
Location:274 → 335

KH-I; K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that ...

pfam00013
Location:98 → 162

KH_1; KH domain
NM_001355373.2 → NP_001342302.1 far upstream element-binding protein 1 isoform 9

Status: VALIDATED

Source sequence(s)

AC123075

UniProtKB/TrEMBL

Q0P6B2, Q3TIS5

Conserved Domains (5) summary

pfam09005
Location:604 → 618

DUF1897; Domain of unknown function (DUF1897)

cd22478
Location:94 → 168

KH-I_FUBP1_rpt1; first type I K homology (KH) RNA-binding domain found in far upstream element-binding protein 1 (FUBP1) and similar proteins

cd22481
Location:182 → 251

KH-I_FUBP1_rpt2; second type I K homology (KH) RNA-binding domain found in far upstream element-binding protein 1 (FUBP1) and similar proteins

cd22484
Location:272 → 339

KH-I_FUBP1_rpt3; third type I K homology (KH) RNA-binding domain found in far upstream element-binding protein 1 (FUBP1) and similar proteins

cd22487
Location:372 → 443

KH-I_FUBP1_rpt4; fourth type I K homology (KH) RNA-binding domain found in far upstream element-binding protein 1 (FUBP1) and similar proteins
NM_001355374.2 → NP_001342303.1 far upstream element-binding protein 1 isoform 10

Status: VALIDATED

Source sequence(s)

AC123075

UniProtKB/TrEMBL

Q3TIS5

Related

ENSMUSP00000143370.2, ENSMUST00000198227.5

Conserved Domains (2) summary

cd00105
Location:273 → 334

KH-I; K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that ...

pfam00013
Location:97 → 161

KH_1; KH domain
NM_001428764.1 → NP_001415693.1 far upstream element-binding protein 1 isoform 11

Status: VALIDATED

Source sequence(s)

AC123075
NM_057172.5 → NP_476513.2 far upstream element-binding protein 1 isoform 8

See identical proteins and their annotated locations for NP_476513.2

Status: VALIDATED

Source sequence(s)

AC123075

Consensus CDS

CCDS38672.1

UniProtKB/TrEMBL

Q3TIS5, Q3TUE1

Related

ENSMUSP00000130145.2, ENSMUST00000166984.8

Conserved Domains (2) summary

cd00105
Location:97 → 159

KH-I; K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that ...

pfam09005
Location:606 → 620

DUF1897; Domain of unknown function (DUF1897)

RNA

NR_149713.2 RNA Sequence

Status: VALIDATED

Source sequence(s)

AC123075

Related

ENSMUST00000199876.5

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000069.7 Reference GRCm39 C57BL/6J

Range

151916059..151942467

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006501672.2 → XP_006501735.1 far upstream element-binding protein 1 isoform X8

UniProtKB/TrEMBL

Q3TIS5

Conserved Domains (3) summary

cd00105
Location:97 → 159

KH-I; K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that ...

pfam00013
Location:376 → 440

KH_1; KH domain

pfam09005
Location:603 → 617

DUF1897; Domain of unknown function (DUF1897)
XM_036163154.1 → XP_036019047.1 far upstream element-binding protein 1 isoform X6

UniProtKB/TrEMBL

Q3TIS5

Conserved Domains (5) summary

pfam09005
Location:603 → 617

DUF1897; Domain of unknown function (DUF1897)

cd22478
Location:93 → 167

KH-I_FUBP1_rpt1; first type I K homology (KH) RNA-binding domain found in far upstream element-binding protein 1 (FUBP1) and similar proteins

cd22481
Location:181 → 250

KH-I_FUBP1_rpt2; second type I K homology (KH) RNA-binding domain found in far upstream element-binding protein 1 (FUBP1) and similar proteins

cd22484
Location:271 → 338

KH-I_FUBP1_rpt3; third type I K homology (KH) RNA-binding domain found in far upstream element-binding protein 1 (FUBP1) and similar proteins

cd22487
Location:371 → 442

KH-I_FUBP1_rpt4; fourth type I K homology (KH) RNA-binding domain found in far upstream element-binding protein 1 (FUBP1) and similar proteins
XM_006501663.2 → XP_006501726.1 far upstream element-binding protein 1 isoform X3

UniProtKB/TrEMBL

Q3TIS5

Conserved Domains (3) summary

cd00105
Location:119 → 181

KH-I; K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that ...

pfam00013
Location:398 → 462

KH_1; KH domain

pfam09005
Location:628 → 642

DUF1897; Domain of unknown function (DUF1897)
XM_006501664.2 → XP_006501727.1 far upstream element-binding protein 1 isoform X4

UniProtKB/TrEMBL

Q3TIS5

Conserved Domains (3) summary

cd00105
Location:119 → 181

KH-I; K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that ...

pfam00013
Location:398 → 462

KH_1; KH domain

pfam09005
Location:628 → 642

DUF1897; Domain of unknown function (DUF1897)
XM_006501660.2 → XP_006501723.1 far upstream element-binding protein 1 isoform X1

UniProtKB/TrEMBL

Q3TIS5

Conserved Domains (3) summary

cd00105
Location:119 → 181

KH-I; K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that ...

pfam00013
Location:398 → 462

KH_1; KH domain

pfam09005
Location:628 → 642

DUF1897; Domain of unknown function (DUF1897)
XM_030252673.1 → XP_030108533.1 far upstream element-binding protein 1 isoform X5

UniProtKB/TrEMBL

Q3TIS5

Conserved Domains (3) summary

cd00105
Location:119 → 181

KH-I; K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that ...

pfam00013
Location:398 → 462

KH_1; KH domain

pfam09005
Location:625 → 639

DUF1897; Domain of unknown function (DUF1897)
XM_006501662.2 → XP_006501725.1 far upstream element-binding protein 1 isoform X2

UniProtKB/TrEMBL

Q3TIS5

Conserved Domains (3) summary

cd00105
Location:119 → 181

KH-I; K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that ...

pfam00013
Location:398 → 462

KH_1; KH domain

pfam09005
Location:625 → 639

DUF1897; Domain of unknown function (DUF1897)
XM_030252674.2 → XP_030108534.1 far upstream element-binding protein 1 isoform X7

Conserved Domains (3) summary

cd00105
Location:118 → 180

KH-I; K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that ...

pfam00013
Location:397 → 461

KH_1; KH domain

pfam09005
Location:624 → 638

DUF1897; Domain of unknown function (DUF1897)