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    OR52K1 olfactory receptor family 52 subfamily K member 1 [ Homo sapiens (human) ]

    Gene ID: 390036, updated on 27-Aug-2024

    Summary

    Official Symbol
    OR52K1provided by HGNC
    Official Full Name
    olfactory receptor family 52 subfamily K member 1provided by HGNC
    Primary source
    HGNC:HGNC:15222
    See related
    Ensembl:ENSG00000196778 AllianceGenome:HGNC:15222
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    OR11-8
    Summary
    Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
    Orthologs
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    Genomic context

    Location:
    11p15.4
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (4482646..4493497)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (4547765..4558606)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (4503876..4514727)

    Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene olfactory receptor family 52 subfamily K member 2 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr11:4485052-4486251 Neighboring gene olfactory receptor family 52 subfamily K member 3 pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4324 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr11:4516376-4517575 Neighboring gene olfactory receptor family 52 subfamily M member 2 pseudogene Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr11:4544619-4545119 Neighboring gene olfactory receptor family 52 subfamily M member 1

    Genomic regions, transcripts, and products

    Phenotypes

    EBI GWAS Catalog

    Description
    A high-density genome-wide association screen of sporadic ALS in US veterans.
    EBI GWAS Catalog
    Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
    EBI GWAS Catalog

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables G protein-coupled receptor activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables olfactory receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    olfactory receptor 52K1
    Names
    olfactory receptor OR11-8

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001005171.3NP_001005171.2  olfactory receptor 52K1 isoform 1

      See identical proteins and their annotated locations for NP_001005171.2

      Status: VALIDATED

      Source sequence(s)
      AC010930
      Consensus CDS
      CCDS31352.1
      UniProtKB/Swiss-Prot
      B9EH54, Q6IFK5, Q8NGK4
      UniProtKB/TrEMBL
      A0A126GVF2, A0A126GWP0
      Related
      ENSP00000493011.1, ENST00000641528.1
      Conserved Domains (2) summary
      pfam00001
      Location:43294
      7tm_1; 7 transmembrane receptor (rhodopsin family)
      cl21561
      Location:33312
      7tm_4; Olfactory receptor
    2. NM_001385736.1NP_001372665.1  olfactory receptor 52K1 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC010930
      Consensus CDS
      CCDS91422.1
      UniProtKB/TrEMBL
      A0A126GWP0, A0A2R8Y546
      Related
      ENSP00000494197.1, ENST00000642020.1
      Conserved Domains (1) summary
      cd15948
      Location:13289
      7tmA_OR52K-like; olfactory receptor subfamily 52K and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

      Range
      4482646..4493497
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060935.1 Alternate T2T-CHM13v2.0

      Range
      4547765..4558606
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)