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    Cenpq centromere protein Q [ Mus musculus (house mouse) ]

    Gene ID: 83815, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Cenpqprovided by MGI
    Official Full Name
    centromere protein Qprovided by MGI
    Primary source
    MGI:MGI:1933744
    See related
    Ensembl:ENSMUSG00000023919 AllianceGenome:MGI:1933744
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    2610528M18Rik
    Summary
    Predicted to be involved in metaphase chromosome alignment and positive regulation of protein localization to kinetochore. Predicted to be located in actin cytoskeleton and nucleoplasm. Predicted to be part of inner kinetochore. Predicted to be active in nucleus. Is expressed in cerebral cortex ventricular layer; embryo; and otocyst. Orthologous to human CENPQ (centromere protein Q). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in liver E14 (RPKM 14.0), CNS E11.5 (RPKM 11.3) and 13 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Cenpq in Genome Data Viewer
    Location:
    17 B2; 17 19.55 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (41231700..41247637, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (40920809..40934574, complement)

    Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 9130008F23 gene Neighboring gene glycine-N-acyltransferase-like 3 Neighboring gene CapStarr-seq enhancer MGSCv37_chr17:41071423-41071532 Neighboring gene methylmalonyl-Coenzyme A mutase Neighboring gene predicted gene, 54006 Neighboring gene STARR-seq mESC enhancer starr_42552 Neighboring gene lactate dehydrogenase A, pseudogene 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Genomic structure of murine methylmalonyl-CoA mutase: evidence for genetic and epigenetic mechanisms determining enzyme activity. Wilkemeyer MF, et al. Biochem J, 1993 Dec 15. PMID 7904153, Free PMC Article
    2. Structural insights into human CCAN complex assembled onto DNA. Tian T, et al. Cell Discov, 2022 Sep 9. PMID 36085283, Free PMC Article
    3. Identification and analysis of genes from the mouse otic vesicle and their association with developmental subprocesses through in situ hybridization. Powles N, et al. Dev Biol, 2004 Apr 1. PMID 15031102
    4. Transcription factor Foxp3 and its protein partners form a complex regulatory network. Rudra D, et al. Nat Immunol, 2012 Oct. PMID 22922362, Free PMC Article
    5. Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development. Bedogni F, et al. Front Mol Neurosci, 2021. PMID 34321999, Free PMC Article

    See all (20) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Process Evidence Code Pubs
    involved_in chromosome segregation NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in metaphase chromosome alignment ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in metaphase chromosome alignment ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in positive regulation of protein localization to kinetochore ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of protein localization to kinetochore ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in actin cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in actin cytoskeleton ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of inner kinetochore ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus NAS
    Non-traceable Author Statement
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    centromere protein Q
    Names
    CENP-Q

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_031863.4 → NP_114069.2  centromere protein Q

      Status: VALIDATED

      Source sequence(s)
      AC121932, AK076094, BY078791
      Consensus CDS
      CCDS28789.1
      UniProtKB/Swiss-Prot
      Q8C2G4, Q8VEF8, Q9CPQ5, Q9CX70
      UniProtKB/TrEMBL
      A0A1I7Q4A6
      Related
      ENSMUSP00000084353.5, ENSMUST00000087114.5
      Conserved Domains (1) summary
      pfam13094
      Location:116 → 266
      CENP-Q; a CENPA-CAD centromere complex subunit

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000083.7 Reference GRCm39 C57BL/6J

      Range
      41231700..41247637 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036160859.1 → XP_036016752.1  centromere protein Q isoform X1

      Conserved Domains (1) summary
      pfam13094
      Location:119 → 161
      CENP-Q; a CENPA-CAD centromere complex subunit
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9CPQ5.2 GenPept UniProtKB/Swiss-Prot:Q9CPQ5

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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