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    Taf12 TATA-box binding protein associated factor 12 [ Mus musculus (house mouse) ]

    Gene ID: 66464, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Taf12provided by MGI
    Official Full Name
    TATA-box binding protein associated factor 12provided by MGI
    Primary source
    MGI:MGI:1913714
    See related
    Ensembl:ENSMUSG00000028899 AllianceGenome:MGI:1913714
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    20kDa; Taf2J; 2810422D08Rik
    Summary
    Enables DNA binding activity. Predicted to be involved in RNA polymerase II preinitiation complex assembly; mRNA transcription by RNA polymerase II; and positive regulation of transcription initiation by RNA polymerase II. Located in nucleus. Part of SAGA complex. Is expressed in early conceptus; limb; oocyte; and tail. Orthologous to human TAF12 (TATA-box binding protein associated factor 12). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in liver E14 (RPKM 16.3), liver E14.5 (RPKM 13.3) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Taf12 in Genome Data Viewer
    Location:
    4 D2.3; 4 65.09 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (132001667..132020640)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (132274355..132293329)

    Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene glucocorticoid modulatory element binding protein 1 Neighboring gene predicted gene 28874 Neighboring gene STARR-positive B cell enhancer ABC_E3519 Neighboring gene U11 small nuclear RNA Neighboring gene STARR-positive B cell enhancer ABC_E6228 Neighboring gene RAB42, member RAS oncogene family Neighboring gene small nucleolar RNA, H/ACA box 16A Neighboring gene small nucleolar RNA host gene 12

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Crystal structure of a subcomplex of human transcription factor TFIID formed by TATA binding protein-associated factors hTAF4 (hTAF(II)135) and hTAF12 (hTAF(II)20). Werten S, et al. J Biol Chem, 2002 Nov 22. PMID 12237304
    2. The Pol II preinitiation complex (PIC) influences Mediator binding but not promoter-enhancer looping. Sun F, et al. Genes Dev, 2021 Aug 1. PMID 34301767, Free PMC Article
    3. Lamin A/C and emerin are critical for skeletal muscle satellite cell differentiation. Frock RL, et al. Genes Dev, 2006 Feb 15. PMID 16481476, Free PMC Article
    4. Role of ATF7-TAF12 interactions in the vitamin D response hypersensitivity of osteoclast precursors in Paget's disease. Teramachi J, et al. J Bone Miner Res, 2013 Jun. PMID 23426901, Free PMC Article
    5. TATA-binding associated factors have distinct roles during early mammalian development. He XD, et al. Dev Biol, 2024 Jul. PMID 38593904,

    See all (42) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The Pol II preinitiation complex (PIC) influences Mediator binding but not promoter-enhancer looping.
      Title: The Pol II preinitiation complex (PIC) influences Mediator binding but not promoter-enhancer looping.
    2. ATF7 interacts with TAF12 and contributes to the hypersensitivity of OCL precursors to 1,25-(OH)D in PD.
      Title: Role of ATF7-TAF12 interactions in the vitamin D response hypersensitivity of osteoclast precursors in Paget's disease.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables DNA-binding transcription factor binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    contributes_to RNA polymerase II general transcription initiation factor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables TBP-class protein binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein heterodimerization activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transcription coactivator activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA-templated transcription initiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in RNA polymerase II preinitiation complex assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in RNA polymerase II preinitiation complex assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in RNA polymerase II preinitiation complex assembly ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in mRNA transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in mRNA transcription by RNA polymerase II ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in positive regulation of DNA-templated transcription NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of transcription initiation by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of transcription initiation by RNA polymerase II ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in regulation of DNA repair NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in regulation of DNA-templated transcription NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in regulation of RNA splicing NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in transcription initiation at RNA polymerase II promoter ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    part_of SAGA complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of SAGA complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of SAGA complex NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in nucleus IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    part_of transcription factor TFIID complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of transcription factor TFIID complex ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    part_of transcription factor TFIID complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    part_of transcription factor TFTC complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of transcription factor TFTC complex NAS
    Non-traceable Author Statement
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    transcription initiation factor TFIID subunit 12
    Names
    TAF12 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 20 kDa
    TAFII-20
    TAFII20
    transcription initiation factor TFIID 20 kDa subunits

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_025579.3 → NP_079855.2  transcription initiation factor TFIID subunit 12

      See identical proteins and their annotated locations for NP_079855.2

      Status: VALIDATED

      Source sequence(s)
      AK132927, AK139748, BE630738, BY069348
      Consensus CDS
      CCDS18721.1
      UniProtKB/Swiss-Prot
      Q3V0S7, Q8VE65, Q9CZ11, Q9D8Q0
      UniProtKB/TrEMBL
      Q3UT56
      Related
      ENSMUSP00000030731.5, ENSMUST00000030731.11
      Conserved Domains (1) summary
      cd07981
      Location:58 → 126
      TAF12; TATA Binding Protein (TBP) Associated Factor 12

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000070.7 Reference GRCm39 C57BL/6J

      Range
      132001667..132020640
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006539110.3 → XP_006539173.1  transcription initiation factor TFIID subunit 12 isoform X3

      See identical proteins and their annotated locations for XP_006539173.1

      UniProtKB/Swiss-Prot
      Q3V0S7, Q8VE65, Q9CZ11, Q9D8Q0
      UniProtKB/TrEMBL
      Q3UT56
      Conserved Domains (1) summary
      cd07981
      Location:58 → 126
      TAF12; TATA Binding Protein (TBP) Associated Factor 12

    2. XM_006539109.2 → XP_006539172.1  transcription initiation factor TFIID subunit 12 isoform X3

      See identical proteins and their annotated locations for XP_006539172.1

      UniProtKB/Swiss-Prot
      Q3V0S7, Q8VE65, Q9CZ11, Q9D8Q0
      UniProtKB/TrEMBL
      Q3UT56
      Conserved Domains (1) summary
      cd07981
      Location:58 → 126
      TAF12; TATA Binding Protein (TBP) Associated Factor 12

    3. XM_036164314.1 → XP_036020207.1  transcription initiation factor TFIID subunit 12 isoform X2

      UniProtKB/TrEMBL
      E9QNT5
      Related
      ENSMUSP00000101583.2, ENSMUST00000105963.2
      Conserved Domains (1) summary
      cd07981
      Location:110 → 178
      TAF12; TATA Binding Protein (TBP) Associated Factor 12

    4. XM_017320350.2 → XP_017175839.2  transcription initiation factor TFIID subunit 12 isoform X1

      UniProtKB/TrEMBL
      Q3UT56
      Conserved Domains (1) summary
      cd07981
      Location:92 → 160
      TAF12; TATA Binding Protein (TBP) Associated Factor 12
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8VE65.1 GenPept UniProtKB/Swiss-Prot:Q8VE65

    Gene LinkOut

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