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    Prorp protein only RNase P catalytic subunit [ Mus musculus (house mouse) ]

    Gene ID: 66132, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Prorpprovided by MGI
    Official Full Name
    protein only RNase P catalytic subunitprovided by MGI
    Primary source
    MGI:MGI:1913382
    See related
    Ensembl:ENSMUSG00000021023 AllianceGenome:MGI:1913382
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Mrpp3; mKIAA0391; 1110008L16Rik
    Summary
    Predicted to enable ribonuclease P activity. Predicted to be involved in mitochondrial tRNA 5'-end processing and tRNA 5'-leader removal. Located in mitochondrial nucleoid. Human ortholog(s) of this gene implicated in combined oxidative phosphorylation deficiency 54. Orthologous to human PRORP (protein only RNase P catalytic subunit). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 2.8), bladder adult (RPKM 2.7) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Prorp in Genome Data Viewer
    Location:
    12 C1; 12 23.91 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (55349422..55429276)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (55302637..55382492)

    Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene family with sequence similarity 177 member A2 Neighboring gene STARR-positive B cell enhancer mm9_chr12:56329932-56330232 Neighboring gene predicted gene 2446 Neighboring gene signal recognition particle 54C Neighboring gene protein phosphatase 2, regulatory subunit B'', gamma Neighboring gene STARR-positive B cell enhancer ABC_E3052 Neighboring gene STARR-positive B cell enhancer ABC_E3053 Neighboring gene CapStarr-seq enhancer MGSCv37_chr12:56490469-56490652 Neighboring gene STARR-positive B cell enhancer ABC_E8483 Neighboring gene ribosomal protein L18A, pseudogene 1 Neighboring gene proteasome subunit alpha 6 Neighboring gene mitochondrial import inner membrane translocase subunit Tim8 B pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Simultaneous processing and degradation of mitochondrial RNAs revealed by circularized RNA sequencing. Kuznetsova I, et al. Nucleic Acids Res, 2017 May 19. PMID 28201688, Free PMC Article
    2. Hierarchical RNA Processing Is Required for Mitochondrial Ribosome Assembly. Rackham O, et al. Cell Rep, 2016 Aug 16. PMID 27498866
    3. Initial steps in RNA processing and ribosome assembly occur at mitochondrial DNA nucleoids. Bogenhagen DF, et al. Cell Metab, 2014 Apr 1. PMID 24703694
    4. The interactome of intact mitochondria by cross-linking mass spectrometry provides evidence for coexisting respiratory supercomplexes. Liu F, et al. Mol Cell Proteomics, 2018 Feb. PMID 29222160, Free PMC Article
    5. Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. Okazaki N, et al. DNA Res, 2004 Jun 30. PMID 15368895

    See all (23) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (2)  1 citation

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • KIAA0391

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ribonuclease P activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ribonuclease P activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables ribonuclease P activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in mitochondrial tRNA 5'-end processing IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitochondrial tRNA 5'-end processing ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in mitochondrial tRNA 5'-end processing ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in tRNA 5'-leader removal IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in mitochondrial nucleoid IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of mitochondrial ribonuclease P complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of mitochondrial ribonuclease P complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of mitochondrial ribonuclease P complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    mitochondrial ribonuclease P catalytic subunit
    Names
    mitochondrial RNase P protein 3
    mitochondrial ribonuclease P protein 3
    NP_079649.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_025373.1 → NP_079649.1  mitochondrial ribonuclease P catalytic subunit precursor

      See identical proteins and their annotated locations for NP_079649.1

      Status: VALIDATED

      Source sequence(s)
      AK031144, AK151976, AV233350
      Consensus CDS
      CCDS49068.1
      UniProtKB/Swiss-Prot
      Q6A076, Q8BSN8, Q8JZY4, Q9CTH1, Q9D7W9
      UniProtKB/TrEMBL
      V9GXP4
      Related
      ENSMUSP00000021411.8, ENSMUST00000021411.15
      Conserved Domains (2) summary
      sd00004
      Location:171 → 201
      PPR; PPR repeat [structural motif]
      pfam16953
      Location:339 → 575
      PRORP; Protein-only RNase P

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000078.7 Reference GRCm39 C57BL/6J

      Range
      55349422..55429276
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8JZY4.1 GenPept UniProtKB/Swiss-Prot:Q8JZY4

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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