PRSS37 serine protease 37 [Homo sapiens (human)] - Gene

Summary

Official Symbol: PRSS37provided by HGNC
Official Full Name: serine protease 37provided by HGNC
Primary source: HGNC:HGNC:29211
See related: Ensembl:ENSG00000165076 AllianceGenome:HGNC:29211
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: TRYX2
Summary: Predicted to enable serine-type endopeptidase activity. Involved in positive regulation of acrosome reaction and regulation of protein processing. Located in acrosomal vesicle. [provided by Alliance of Genome Resources, Nov 2024]
Expression: Restricted expression toward testis (RPKM 1.6) See more
Orthologs: mouse all
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Genomic context

Location:: 7q34

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	7	NC_000007.14 (141836278..141841485, complement)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	7	NC_060931.1 (143152100..143157307, complement)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	7	NC_000007.13 (141536078..141541285, complement)

Chromosome 7 - NC_000007.14 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Sperm with low PRSS37 contents exhibit abnormal activation of the proacrosin/acrosin system and premature proteolysis of ADAM2, which may impair the functional competence of human sperm in vivo
Title: Low levels of PRSS37 protein in sperm are associated with many cases of unexplained male infertility.

Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
NOT enables serine-type endopeptidase activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in binding of sperm to zona pellucida	ISS Inferred from Sequence or Structural Similarity more info
involved_in cell migration	ISS Inferred from Sequence or Structural Similarity more info
involved_in germ cell migration	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of acrosome reaction	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of acrosome reaction	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of fertilization	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein maturation	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein maturation	ISS Inferred from Sequence or Structural Similarity more info
involved_in proteolysis	IEA Inferred from Electronic Annotation more info
involved_in regulation of protein processing	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in acrosomal vesicle	IBA Inferred from Biological aspect of Ancestor more info
located_in acrosomal vesicle	IDA Inferred from Direct Assay more info	PubMed
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	HDA more info	PubMed

General protein information

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Preferred Names: probable inactive serine protease 37

Names: Peptidase S1 domain-containing protein LOC136242; probable inactive trypsin-X2; protease, serine 37

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001008270.3 → NP_001008271.2 probable inactive serine protease 37 isoform 1 precursor

See identical proteins and their annotated locations for NP_001008271.2

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (1).

Source sequence(s)

AA628371, AC093638, AK172866, BC137353

Consensus CDS

CCDS34764.1

UniProtKB/Swiss-Prot

A4D1T9, B2RPB5

Related

ENSP00000297767.3, ENST00000350549.8

Conserved Domains (1) summary

cl21584
Location:28 → 231

Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
NM_001171951.2 → NP_001165422.1 probable inactive serine protease 37 isoform 2 precursor

See identical proteins and their annotated locations for NP_001165422.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 5' coding region, compared to variant 1. This results in a shorter protein (isoform 2), compared to isoform 1.

Source sequence(s)

AA628371, AC093638, AK172866, BC144605

UniProtKB/TrEMBL

B7ZMK3

Conserved Domains (2) summary

smart00020
Location:28 → 227

Tryp_SPc; Trypsin-like serine protease

cl21584
Location:28 → 230

Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
NM_001370403.1 → NP_001357332.1 probable inactive serine protease 37 isoform 1 precursor

Status: VALIDATED

Source sequence(s)

AC093638

Consensus CDS

CCDS34764.1

UniProtKB/Swiss-Prot

A4D1T9, B2RPB5

Related

ENSP00000414461.1, ENST00000438520.1

Conserved Domains (1) summary

cl21584
Location:28 → 231

Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000007.14 Reference GRCh38.p14 Primary Assembly

Range

141836278..141841485 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_005249947.4 → XP_005250004.1 probable inactive serine protease 37 isoform X1

See identical proteins and their annotated locations for XP_005250004.1

Conserved Domains (2) summary

smart00020
Location:28 → 258

Tryp_SPc; Trypsin-like serine protease

cl21584
Location:28 → 261

Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
XM_047419883.1 → XP_047275839.1 probable inactive serine protease 37 isoform X2
XM_047419884.1 → XP_047275840.1 probable inactive serine protease 37 isoform X2