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    Cnpy2 canopy FGF signaling regulator 2 [ Mus musculus (house mouse) ]

    Gene ID: 56530, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Cnpy2provided by MGI
    Official Full Name
    canopy FGF signaling regulator 2provided by MGI
    Primary source
    MGI:MGI:1928477
    See related
    Ensembl:ENSMUSG00000025381 AllianceGenome:MGI:1928477
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Tmem4; Zsig9; D10Bwg1546e; 5330432A10Rik
    Summary
    Predicted to be active in endoplasmic reticulum. Is expressed in embryo. Orthologous to human CNPY2 (canopy FGF signaling regulator 2). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in placenta adult (RPKM 39.1), limb E14.5 (RPKM 36.9) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Cnpy2 in Genome Data Viewer
    Location:
    10 D3; 10 76.52 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (128157972..128163056)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (128322158..128327187)

    Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E194 Neighboring gene interleukin 23, alpha subunit p19 Neighboring gene CapStarr-seq enhancer MGSCv37_chr10:127740631-127740818 Neighboring gene predicted gene, 23241 Neighboring gene PAN2 poly(A) specific ribonuclease subunit Neighboring gene STARR-positive B cell enhancer ABC_E9813 Neighboring gene STARR-positive B cell enhancer ABC_E1134 Neighboring gene STARR-positive B cell enhancer ABC_E11467 Neighboring gene citrate synthase Neighboring gene predicted gene, 23182 Neighboring gene CapStarr-seq enhancer MGSCv37_chr10:127806017-127806126 Neighboring gene coenzyme Q10A

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. The role of CNPY2 in endothelial injury and inflammation during the progress of atherosclerosis. Huang H, et al. J Mol Histol, 2023 Jun. PMID 37103758
    2. Canopy Homolog 2 contributes to liver oncogenesis by promoting unfolded protein response-dependent destabilization of tumor protein P53. Hong F, et al. Hepatology, 2022 Dec. PMID 34986508
    3. Expression of CNPY2 in mouse tissues: quantification and localization. Hatta K, et al. PLoS One, 2014. PMID 25393402, Free PMC Article
    4. A secreted protein (Canopy 2, CNPY2) enhances angiogenesis and promotes smooth muscle cell migration and proliferation. Guo J, et al. Cardiovasc Res, 2015 Mar 1. PMID 25589425
    5. Decreasing CNPY2 Expression Diminishes Colorectal Tumor Growth and Development through Activation of p53 Pathway. Yan P, et al. Am J Pathol, 2016 Apr. PMID 26835537

    See all (32) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The role of CNPY2 in endothelial injury and inflammation during the progress of atherosclerosis.
      Title: The role of CNPY2 in endothelial injury and inflammation during the progress of atherosclerosis.
    2. Canopy Homolog 2 contributes to liver oncogenesis by promoting unfolded protein response-dependent destabilization of tumor protein P53.
      Title: Canopy Homolog 2 contributes to liver oncogenesis by promoting unfolded protein response-dependent destabilization of tumor protein P53.
    3. Sustained PERK activation can amplify PERK signaling by further enhancing CNPY2 expression via direct transactivation through CHOP.
      Title: Fine-tuning PERK signaling to control cell fate under stress.
    4. Free CNPY2 then engages protein kinase R-like endoplasmic reticulum kinase (PERK) to induce expression of the transcription factor C/EBP homologous protein (CHOP), thereby initiating the unfolded protein response.
      Title: CNPY2 is a key initiator of the PERK-CHOP pathway of the unfolded protein response.
    5. CNPY2 may play a critical role in colorectal cancer development by enhancing cell proliferation, migration, and angiogenesis and by inhibiting apoptosis through negative regulation of the p53 pathway
      Title: Decreasing CNPY2 Expression Diminishes Colorectal Tumor Growth and Development through Activation of p53 Pathway.
    6. The data demonstrate CNPY2 is widely distributed in tissues and suggest the protein has biological functions that have yet to be identified.
      Title: Expression of CNPY2 in mouse tissues: quantification and localization.
    7. CNPY2 is a HIF-1alpha-regulated, secreted angiogenic growth factor that promotes smooth muscle cell migration, proliferation, and tissue revascularization.
      Title: A secreted protein (Canopy 2, CNPY2) enhances angiogenesis and promotes smooth muscle cell migration and proliferation.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Gene trapped (1) 
    • Targeted (2)  1 citation

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of negative regulation of gene expression IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of positive regulation of low-density lipoprotein receptor activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of regulation of low-density lipoprotein particle clearance IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    protein canopy homolog 2
    Names
    MIR-interacting saposin-like protein
    canopy 2 homolog
    putative secreted protein ZSIG9
    transmembrane protein 4

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001429229.1 → NP_001416158.1  protein canopy homolog 2 precursor

      Status: VALIDATED

      Source sequence(s)
      AC090489
      UniProtKB/Swiss-Prot
      Q3UBH8, Q9QXT0

    2. NM_001429230.1 → NP_001416159.1  protein canopy homolog 2 precursor

      Status: VALIDATED

      Source sequence(s)
      AC090489
      UniProtKB/Swiss-Prot
      Q3UBH8, Q9QXT0

    3. NM_001429231.1 → NP_001416160.1  protein canopy homolog 2 precursor

      Status: VALIDATED

      Source sequence(s)
      AC090489
      UniProtKB/Swiss-Prot
      Q3UBH8, Q9QXT0

    4. NM_001429232.1 → NP_001416161.1  protein canopy homolog 2 precursor

      Status: VALIDATED

      Source sequence(s)
      AC090489
      UniProtKB/Swiss-Prot
      Q3UBH8, Q9QXT0

    5. NM_019953.2 → NP_064337.1  protein canopy homolog 2 precursor

      See identical proteins and their annotated locations for NP_064337.1

      Status: VALIDATED

      Source sequence(s)
      AC090489
      Consensus CDS
      CCDS24272.1
      UniProtKB/Swiss-Prot
      Q3UBH8, Q9QXT0
      Related
      ENSMUSP00000151918.2, ENSMUST00000219037.2
      Conserved Domains (1) summary
      pfam11938
      Location:27 → 165
      DUF3456; TLR4 regulator and MIR-interacting MSAP

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000076.7 Reference GRCm39 C57BL/6J

      Range
      128157972..128163056
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006513902.5 → XP_006513965.1  protein canopy homolog 2 isoform X2

      Related
      ENSMUSP00000026446.3, ENSMUST00000026446.4
      Conserved Domains (1) summary
      pfam11938
      Location:27 → 165
      DUF3456; TLR4 regulator and MIR-interacting MSAP

    2. XM_030245184.2 → XP_030101044.1  protein canopy homolog 2 isoform X1

      Conserved Domains (1) summary
      pfam11938
      Location:46 → 184
      DUF3456; TLR4 regulator and MIR-interacting MSAP
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9QXT0.1 GenPept UniProtKB/Swiss-Prot:Q9QXT0

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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