ATP2A3 ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 3 [Homo sapiens (human)] - Gene

Summary

Official Symbol: ATP2A3provided by HGNC
Official Full Name: ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 3provided by HGNC
Primary source: HGNC:HGNC:813
See related: Ensembl:ENSG00000074370 MIM:601929; AllianceGenome:HGNC:813
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: SERCA3
Summary: This gene encodes one of the SERCA Ca(2+)-ATPases, which are intracellular pumps located in the sarcoplasmic or endoplasmic reticula of muscle cells. This enzyme catalyzes the hydrolysis of ATP coupled with the translocation of calcium from the cytosol to the sarcoplasmic reticulum lumen, and is involved in calcium sequestration associated with muscular excitation and contraction. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
Expression: Broad expression in lymph node (RPKM 38.6), stomach (RPKM 37.7) and 18 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 17p13.2

Exon count:: 25

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	17	NC_000017.11 (3923873..3964437, complement)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	17	NC_060941.1 (3813121..3853682, complement)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	17	NC_000017.10 (3827167..3867731, complement)

Chromosome 17 - NC_000017.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Sarco/endoplasmic reticulum calcium ATPase 3 (SERCA3) expression in gastrointestinal stromal tumours.
Title: Sarco/endoplasmic reticulum calcium ATPase 3 (SERCA3) expression in gastrointestinal stromal tumours.
Data show that the nucleotide sequence from -280 to -135 position is an ATP2A3 epigenetic regulatory CpG region. SERCA3 mRNA expression is decreased during gastric and colorectal carcinoma development and tumors with high SERCA3 expression are associated with increased overall survival. These results suggest an essential role for SERCA3 in the regulation of cellular identity and growth, through cellular Ca2+ management.
Title: Epigenetic regulation of the human ATP2A3 gene promoter in gastric and colon cancer cell lines.
This study demonstrates that ATP2A3 might be one of the potential targets for salinomycin, which can inhibit Ca(2+) release and trigger ER stress to exert anti-cancer effects.
Title: Salinomycin triggers endoplasmic reticulum stress through ATP2A3 upregulation in PC-3 cells.
Sp1, Sp3, and Klf-4 transcription factors bind to ATP2A3 proximal promoter elements and regulate basal gene expression. The study showed that these factors participated in the increase of ATP2A3 expression during cancer cell differentiation.
Title: Induction of cell differentiation activates transcription of the Sarco/Endoplasmic Reticulum calcium-ATPase 3 gene (ATP2A3) in gastric and colon cancer cells.
Together, these data provide evidence for the interaction of Bcl-2 with SERCA3b in vitro and in cell culture, and for Bcl-2-dependent conformational and functional changes of SERCA3b.
Title: Inhibition and conformational change of SERCA3b induced by Bcl-2.
ATP2A3 methylation was not altered between patients with type 2 diabetes and healthy men. Moreover, a glucose challenge did not alter ATP2A3 methylation.
Title: Insulin and Glucose Alter Death-Associated Protein Kinase 3 (DAPK3) DNA Methylation in Human Skeletal Muscle.
we make a comprehensive analysis of the current knowledge of the role of the SERCA pumps in the pathophysiology of insulin-dependent diabetes mellitus type 1 (TIDM) and type 2 (T2DM) in the heart and beta-cells in the pancreas
Title: Regulation of SERCA pumps expression in diabetes.
Normal choroid plexus epithelial cells express SERCA3 abundantly, SERCA3 expression is strongly decreased in papillomas, and is absent in choroid plexus carcinoma, while expression in hyperplastic epithelium is high, similarly to normal epithelium.
Title: Loss of endoplasmic reticulum calcium pump expression in choroid plexus tumours.
aberrant SERCA3 expression is closely linked to the adenoma-adenocarcinoma sequence and progression of colorectal carcinomas.
Title: Aberrant SERCA3 expression during the colorectal adenoma-adenocarcinoma sequence.
The Ca2+-ATPase activity in cloned Plasmodiuim falciparum strain D6 protein is higher than in cloned strain W2 protein. The Ca2+-ATPase activity in isolates from malaria patients varied widely.
Title: Assessment and characterization of Ca2+-ATPase expression in selected isolates and clones of Plasmodium falciparum.

Submit: New GeneRIF Correction See all GeneRIFs (32)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Protein interactions

Protein	Gene	Interaction	Pubs
Envelope surface glycoprotein gp160, precursor	env	HIV-1 Env is identified to have a physical interaction with ATPase, Ca++ transporting, ubiquitous (ATP2A3) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses	PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D17S1575 (e-PCR)
- UniSTS:151868

G42991 (e-PCR)
- UniSTS:94862

G54311 (e-PCR)
- UniSTS:116114

G54314 (e-PCR)
- UniSTS:116117

G54315 (e-PCR)
- UniSTS:116118

RH12619 (e-PCR)
- UniSTS:16887

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables ATP hydrolysis activity	IEA Inferred from Electronic Annotation more info
enables P-type calcium transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables P-type calcium transporter activity	IDA Inferred from Direct Assay more info	PubMed
enables P-type calcium transporter activity	TAS Traceable Author Statement more info
enables calcium ion transmembrane transporter activity	IDA Inferred from Direct Assay more info	PubMed
enables calcium-dependent ATPase activity	IDA Inferred from Direct Assay more info	PubMed
enables cysteine-type endopeptidase activator activity involved in apoptotic process	IDA Inferred from Direct Assay more info	PubMed
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables transmembrane transporter binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in calcium ion transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in calcium ion transmembrane transport	IDA Inferred from Direct Assay more info	PubMed
involved_in calcium ion transport	TAS Traceable Author Statement more info	PubMed
involved_in calcium ion transport from cytosol to endoplasmic reticulum	IDA Inferred from Direct Assay more info	PubMed
involved_in intracellular calcium ion homeostasis	IBA Inferred from Biological aspect of Ancestor more info
involved_in intracellular calcium ion homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress	IDA Inferred from Direct Assay more info	PubMed
involved_in monoatomic ion transmembrane transport	TAS Traceable Author Statement more info
involved_in negative regulation of receptor binding	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of cardiac conduction	TAS Traceable Author Statement more info
involved_in transport across blood-brain barrier	NAS Non-traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
located_in endoplasmic reticulum	IDA Inferred from Direct Assay more info	PubMed
located_in endoplasmic reticulum membrane	TAS Traceable Author Statement more info
is_active_in membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in nuclear membrane	IEA Inferred from Electronic Annotation more info
located_in organelle membrane	IDA Inferred from Direct Assay more info	PubMed
located_in platelet dense tubular network membrane	TAS Traceable Author Statement more info
located_in sarcoplasmic reticulum	IDA Inferred from Direct Assay more info	PubMed
located_in sarcoplasmic reticulum membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: sarcoplasmic/endoplasmic reticulum calcium ATPase 3

Names: ATPase, Ca(2+)-transporting, ubiquitous; ATPase, Ca++ transporting, ubiquitous; SR Ca(2+)-ATPase 3; adenosine triphosphatase, calcium; calcium pump 3; calcium-translocating P-type ATPase; sarco/endoplasmic reticulum Ca2+ -ATPase

NP_005164.2

EC 7.2.2.10

NP_777613.1

EC 7.2.2.10

NP_777614.1

EC 7.2.2.10

NP_777615.1

EC 7.2.2.10

NP_777616.1

EC 7.2.2.10

NP_777617.1

EC 7.2.2.10

NP_777618.1

EC 7.2.2.10

XP_011522183.1

EC 7.2.2.10

XP_011522184.1

EC 7.2.2.10

XP_011522186.1

EC 7.2.2.10

XP_011522187.1

EC 7.2.2.10

XP_011522190.1

EC 7.2.2.10

XP_011522191.1

EC 7.2.2.10

XP_011522194.1

EC 7.2.2.10

XP_047292106.1

EC 7.2.2.10

XP_047292107.1

EC 7.2.2.10

XP_047292108.1

EC 7.2.2.10

XP_047292109.1

EC 7.2.2.10

XP_054172247.1

EC 7.2.2.10

XP_054172248.1

EC 7.2.2.10

XP_054172249.1

EC 7.2.2.10

XP_054172250.1

EC 7.2.2.10

XP_054172251.1

EC 7.2.2.10

XP_054172252.1

EC 7.2.2.10

XP_054172253.1

EC 7.2.2.10

XP_054172254.1

EC 7.2.2.10

XP_054172255.1

EC 7.2.2.10

XP_054172256.1

EC 7.2.2.10

XP_054172257.1

EC 7.2.2.10

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_029041.1 RefSeqGene

Range

5006..45570

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_005173.4 → NP_005164.2 sarcoplasmic/endoplasmic reticulum calcium ATPase 3 isoform a

See identical proteins and their annotated locations for NP_005164.2

Status: REVIEWED

Description

Transcript Variant: This variant (1) encodes isoform a.

Source sequence(s)

AA643105, AC005940, AK292716, BC035729, Z69881

Consensus CDS

CCDS45579.1

UniProtKB/Swiss-Prot

A8MZG0, D3DTJ8, O60900, O60901, O75501, O75502, Q16115, Q6JHX1, Q8TEX5, Q8TEX6, Q93084

UniProtKB/TrEMBL

A8K9K1

Related

ENSP00000380234.3, ENST00000397041.8

Conserved Domains (1) summary

cd02083
Location:5 → 989

P-type_ATPase_SERCA; sarco/endoplasmic reticulum Ca(2+)-ATPase (SERCA), similar to mammalian ATP2A1-3/SERCA1-3
NM_174953.3 → NP_777613.1 sarcoplasmic/endoplasmic reticulum calcium ATPase 3 isoform e

See identical proteins and their annotated locations for NP_777613.1

Status: REVIEWED

Description

Transcript Variant: This variant (5) includes two additional exons in the 3' coding region but maintains the reading frame, compared to variant 1. Variant 5 encodes isoform e, which is longer than isoform a.

Source sequence(s)

AA643105, AC005940, AF458229, AK292716, BC035729, Z69881

Consensus CDS

CCDS11042.1

UniProtKB/TrEMBL

A8K9K1

Related

ENSP00000353072.3, ENST00000359983.7

Conserved Domains (6) summary

TIGR01116
Location:53 → 989

ATPase-IIA1_Ca; sarco/endoplasmic reticulum calcium-translocating P-type ATPase

pfam00122
Location:92 → 340

E1-E2_ATPase; E1-E2 ATPase

pfam00689
Location:784 → 987

Cation_ATPase_C; Cation transporting ATPase, C-terminus

pfam00690
Location:4 → 72

Cation_ATPase_N; Cation transporter/ATPase, N-terminus

pfam12710
Location:604 → 712

HAD; haloacid dehalogenase-like hydrolase

pfam13246
Location:419 → 528

Cation_ATPase; Cation transport ATPase (P-type)
NM_174954.3 → NP_777614.1 sarcoplasmic/endoplasmic reticulum calcium ATPase 3 isoform d

See identical proteins and their annotated locations for NP_777614.1

Status: REVIEWED

Description

Transcript Variant: This variant (4) includes two additional exons in the 3' coding region resulting in a frameshift, compared to variant 1. Variant 4 encodes isoform d, which is longer and has a distinct C-terminus compared to isoform a.

Source sequence(s)

AA643105, AC005940, AF458228, AK292716, BC035729, Z69881

UniProtKB/TrEMBL

A8K9K1

Conserved Domains (6) summary

TIGR01116
Location:53 → 989

ATPase-IIA1_Ca; sarco/endoplasmic reticulum calcium-translocating P-type ATPase

pfam00122
Location:92 → 340

E1-E2_ATPase; E1-E2 ATPase

pfam00689
Location:784 → 987

Cation_ATPase_C; Cation transporting ATPase, C-terminus

pfam00690
Location:4 → 72

Cation_ATPase_N; Cation transporter/ATPase, N-terminus

pfam12710
Location:604 → 712

HAD; haloacid dehalogenase-like hydrolase

pfam13246
Location:419 → 528

Cation_ATPase; Cation transport ATPase (P-type)
NM_174955.3 → NP_777615.1 sarcoplasmic/endoplasmic reticulum calcium ATPase 3 isoform b

See identical proteins and their annotated locations for NP_777615.1

Status: REVIEWED

Description

Transcript Variant: This variant (2) includes an additional exon in the 3' coding region resulting in a frameshift, compared to variant 1. Variant 2 encodes isoform b, which is longer and has a distinct C-terminus compared to isoform a.

Source sequence(s)

AA643105, AC005940, AF458228, AK292716, BC035729, Z69881

Consensus CDS

CCDS11041.1

UniProtKB/TrEMBL

A8K9K1

Related

ENSP00000301387.6, ENST00000352011.7

Conserved Domains (6) summary

TIGR01116
Location:53 → 989

ATPase-IIA1_Ca; sarco/endoplasmic reticulum calcium-translocating P-type ATPase

pfam00122
Location:92 → 340

E1-E2_ATPase; E1-E2 ATPase

pfam00689
Location:784 → 987

Cation_ATPase_C; Cation transporting ATPase, C-terminus

pfam00690
Location:4 → 72

Cation_ATPase_N; Cation transporter/ATPase, N-terminus

pfam12710
Location:604 → 712

HAD; haloacid dehalogenase-like hydrolase

pfam13246
Location:419 → 528

Cation_ATPase; Cation transport ATPase (P-type)
NM_174956.3 → NP_777616.1 sarcoplasmic/endoplasmic reticulum calcium ATPase 3 isoform c

See identical proteins and their annotated locations for NP_777616.1

Status: REVIEWED

Description

Transcript Variant: This variant (3) includes an additional exon in the 3' coding region resulting in a frameshift, compared to variant 1. Variant 3 encodes isoform c, which is longer and has a distinct C-terminus compared to isoform a.

Source sequence(s)

AA643105, AC005940, AF458229, AK292716, BC035729, Z69881

Consensus CDS

CCDS42234.1

UniProtKB/TrEMBL

A8K9K1

Related

ENSP00000312577.7, ENST00000309890.11

Conserved Domains (6) summary

TIGR01116
Location:53 → 989

ATPase-IIA1_Ca; sarco/endoplasmic reticulum calcium-translocating P-type ATPase

pfam00122
Location:92 → 340

E1-E2_ATPase; E1-E2 ATPase

pfam00689
Location:784 → 987

Cation_ATPase_C; Cation transporting ATPase, C-terminus

pfam00690
Location:4 → 72

Cation_ATPase_N; Cation transporter/ATPase, N-terminus

pfam12710
Location:604 → 712

HAD; haloacid dehalogenase-like hydrolase

pfam13246
Location:419 → 528

Cation_ATPase; Cation transport ATPase (P-type)
NM_174957.3 → NP_777617.1 sarcoplasmic/endoplasmic reticulum calcium ATPase 3 isoform f

See identical proteins and their annotated locations for NP_777617.1

Status: REVIEWED

Description

Transcript Variant: This variant (6) uses an alternate in frame splice site in the 3' coding region, compared to variant 1. Variant 6 encodes isoform f, which is one aa shorter than isoform a.

Source sequence(s)

AA643105, AC005940, AF068220, AK292716, BC035729, Z69881

Consensus CDS

CCDS45580.1

UniProtKB/TrEMBL

A8K9K1

Related

ENSP00000380236.3, ENST00000397043.7

Conserved Domains (6) summary

TIGR01116
Location:53 → 989

ATPase-IIA1_Ca; sarco/endoplasmic reticulum calcium-translocating P-type ATPase

pfam00122
Location:92 → 340

E1-E2_ATPase; E1-E2 ATPase

pfam00689
Location:784 → 987

Cation_ATPase_C; Cation transporting ATPase, C-terminus

pfam00690
Location:4 → 72

Cation_ATPase_N; Cation transporter/ATPase, N-terminus

pfam12710
Location:604 → 712

HAD; haloacid dehalogenase-like hydrolase

pfam13246
Location:419 → 528

Cation_ATPase; Cation transport ATPase (P-type)
NM_174958.3 → NP_777618.1 sarcoplasmic/endoplasmic reticulum calcium ATPase 3 isoform c

See identical proteins and their annotated locations for NP_777618.1

Status: REVIEWED

Description

Transcript Variant: This variant (7) includes an additional exon and uses alternate splices in the 3' coding region resulting in a frameshift, compared to variant 1. Variant 7 encodes isoform c, which is longer and has a distinct C-terminus compared to isoform a.

Source sequence(s)

AA643105, AC005940, AF068221, AK292716, BC035729

Consensus CDS

CCDS42234.1

UniProtKB/TrEMBL

A8K9K1

Related

ENSP00000380229.3, ENST00000397035.8

Conserved Domains (6) summary

TIGR01116
Location:53 → 989

ATPase-IIA1_Ca; sarco/endoplasmic reticulum calcium-translocating P-type ATPase

pfam00122
Location:92 → 340

E1-E2_ATPase; E1-E2 ATPase

pfam00689
Location:784 → 987

Cation_ATPase_C; Cation transporting ATPase, C-terminus

pfam00690
Location:4 → 72

Cation_ATPase_N; Cation transporter/ATPase, N-terminus

pfam12710
Location:604 → 712

HAD; haloacid dehalogenase-like hydrolase

pfam13246
Location:419 → 528

Cation_ATPase; Cation transport ATPase (P-type)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000017.11 Reference GRCh38.p14 Primary Assembly

Range

3923873..3964437 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_047436153.1 → XP_047292109.1 sarcoplasmic/endoplasmic reticulum calcium ATPase 3 isoform X9
XM_047436151.1 → XP_047292107.1 sarcoplasmic/endoplasmic reticulum calcium ATPase 3 isoform X6
XM_011523885.2 → XP_011522187.1 sarcoplasmic/endoplasmic reticulum calcium ATPase 3 isoform X4

UniProtKB/TrEMBL

A8K9K1

Conserved Domains (6) summary

TIGR01116
Location:53 → 989

ATPase-IIA1_Ca; sarco/endoplasmic reticulum calcium-translocating P-type ATPase

pfam00122
Location:92 → 340

E1-E2_ATPase; E1-E2 ATPase

pfam00689
Location:784 → 987

Cation_ATPase_C; Cation transporting ATPase, C-terminus

pfam00690
Location:4 → 72

Cation_ATPase_N; Cation transporter/ATPase, N-terminus

pfam12710
Location:604 → 712

HAD; haloacid dehalogenase-like hydrolase

pfam13246
Location:419 → 528

Cation_ATPase; Cation transport ATPase (P-type)
XM_047436150.1 → XP_047292106.1 sarcoplasmic/endoplasmic reticulum calcium ATPase 3 isoform X5
XM_047436152.1 → XP_047292108.1 sarcoplasmic/endoplasmic reticulum calcium ATPase 3 isoform X7
XM_011523888.3 → XP_011522190.1 sarcoplasmic/endoplasmic reticulum calcium ATPase 3 isoform X7

UniProtKB/TrEMBL

A8K9K1

Conserved Domains (6) summary

TIGR01116
Location:53 → 989

ATPase-IIA1_Ca; sarco/endoplasmic reticulum calcium-translocating P-type ATPase

pfam00122
Location:92 → 340

E1-E2_ATPase; E1-E2 ATPase

pfam00689
Location:784 → 987

Cation_ATPase_C; Cation transporting ATPase, C-terminus

pfam00690
Location:4 → 72

Cation_ATPase_N; Cation transporter/ATPase, N-terminus

pfam12710
Location:604 → 712

HAD; haloacid dehalogenase-like hydrolase

pfam13246
Location:419 → 528

Cation_ATPase; Cation transport ATPase (P-type)
XM_011523881.3 → XP_011522183.1 sarcoplasmic/endoplasmic reticulum calcium ATPase 3 isoform X1

UniProtKB/TrEMBL

A8K9K1

Conserved Domains (6) summary

TIGR01116
Location:53 → 989

ATPase-IIA1_Ca; sarco/endoplasmic reticulum calcium-translocating P-type ATPase

pfam00122
Location:92 → 340

E1-E2_ATPase; E1-E2 ATPase

pfam00689
Location:784 → 987

Cation_ATPase_C; Cation transporting ATPase, C-terminus

pfam00690
Location:4 → 72

Cation_ATPase_N; Cation transporter/ATPase, N-terminus

pfam12710
Location:604 → 712

HAD; haloacid dehalogenase-like hydrolase

pfam13246
Location:419 → 528

Cation_ATPase; Cation transport ATPase (P-type)
XM_011523882.3 → XP_011522184.1 sarcoplasmic/endoplasmic reticulum calcium ATPase 3 isoform X2

UniProtKB/TrEMBL

A8K9K1

Conserved Domains (6) summary

TIGR01116
Location:53 → 989

ATPase-IIA1_Ca; sarco/endoplasmic reticulum calcium-translocating P-type ATPase

pfam00122
Location:92 → 340

E1-E2_ATPase; E1-E2 ATPase

pfam00689
Location:784 → 987

Cation_ATPase_C; Cation transporting ATPase, C-terminus

pfam00690
Location:4 → 72

Cation_ATPase_N; Cation transporter/ATPase, N-terminus

pfam12710
Location:604 → 712

HAD; haloacid dehalogenase-like hydrolase

pfam13246
Location:419 → 528

Cation_ATPase; Cation transport ATPase (P-type)
XM_011523884.4 → XP_011522186.1 sarcoplasmic/endoplasmic reticulum calcium ATPase 3 isoform X3

UniProtKB/TrEMBL

A8K9K1

Conserved Domains (6) summary

TIGR01116
Location:53 → 989

ATPase-IIA1_Ca; sarco/endoplasmic reticulum calcium-translocating P-type ATPase

pfam00122
Location:92 → 340

E1-E2_ATPase; E1-E2 ATPase

pfam00689
Location:784 → 987

Cation_ATPase_C; Cation transporting ATPase, C-terminus

pfam00690
Location:4 → 72

Cation_ATPase_N; Cation transporter/ATPase, N-terminus

pfam12710
Location:604 → 712

HAD; haloacid dehalogenase-like hydrolase

pfam13246
Location:419 → 528

Cation_ATPase; Cation transport ATPase (P-type)
XM_011523889.2 → XP_011522191.1 sarcoplasmic/endoplasmic reticulum calcium ATPase 3 isoform X8

UniProtKB/TrEMBL

A8K9K1

Conserved Domains (6) summary

TIGR01116
Location:53 → 989

ATPase-IIA1_Ca; sarco/endoplasmic reticulum calcium-translocating P-type ATPase

pfam00122
Location:92 → 340

E1-E2_ATPase; E1-E2 ATPase

pfam00689
Location:784 → 987

Cation_ATPase_C; Cation transporting ATPase, C-terminus

pfam00690
Location:4 → 72

Cation_ATPase_N; Cation transporter/ATPase, N-terminus

pfam12710
Location:604 → 712

HAD; haloacid dehalogenase-like hydrolase

pfam13246
Location:419 → 528

Cation_ATPase; Cation transport ATPase (P-type)
XM_011523892.3 → XP_011522194.1 sarcoplasmic/endoplasmic reticulum calcium ATPase 3 isoform X10

Conserved Domains (3) summary

pfam00122
Location:92 → 340

E1-E2_ATPase; E1-E2 ATPase

pfam00690
Location:4 → 72

Cation_ATPase_N; Cation transporter/ATPase, N-terminus

pfam13246
Location:419 → 518

Cation_ATPase; Cation transport ATPase (P-type)

Alternate T2T-CHM13v2.0

Genomic

NC_060941.1 Alternate T2T-CHM13v2.0

Range

3813121..3853682 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_054316281.1 → XP_054172256.1 sarcoplasmic/endoplasmic reticulum calcium ATPase 3 isoform X9
XM_054316277.1 → XP_054172252.1 sarcoplasmic/endoplasmic reticulum calcium ATPase 3 isoform X6
XM_054316275.1 → XP_054172250.1 sarcoplasmic/endoplasmic reticulum calcium ATPase 3 isoform X4
XM_054316276.1 → XP_054172251.1 sarcoplasmic/endoplasmic reticulum calcium ATPase 3 isoform X5
XM_054316279.1 → XP_054172254.1 sarcoplasmic/endoplasmic reticulum calcium ATPase 3 isoform X7
XM_054316278.1 → XP_054172253.1 sarcoplasmic/endoplasmic reticulum calcium ATPase 3 isoform X7
XM_054316272.1 → XP_054172247.1 sarcoplasmic/endoplasmic reticulum calcium ATPase 3 isoform X1
XM_054316273.1 → XP_054172248.1 sarcoplasmic/endoplasmic reticulum calcium ATPase 3 isoform X2
XM_054316274.1 → XP_054172249.1 sarcoplasmic/endoplasmic reticulum calcium ATPase 3 isoform X3
XM_054316280.1 → XP_054172255.1 sarcoplasmic/endoplasmic reticulum calcium ATPase 3 isoform X8
XM_054316282.1 → XP_054172257.1 sarcoplasmic/endoplasmic reticulum calcium ATPase 3 isoform X10