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    Rnaseh2c ribonuclease H2, subunit C [ Mus musculus (house mouse) ]

    Gene ID: 68209, updated on 2-Nov-2024

    Summary

    Official Symbol
    Rnaseh2cprovided by MGI
    Official Full Name
    ribonuclease H2, subunit Cprovided by MGI
    Primary source
    MGI:MGI:1915459
    See related
    Ensembl:ENSMUSG00000024925 AllianceGenome:MGI:1915459
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    AYP1; 1500026D16Rik
    Summary
    Predicted to be involved in RNA catabolic process. Part of ribonuclease H2 complex. Is expressed in several structures, including hemolymphoid system gland; retina nuclear layer; skin; telencephalon; and testis. Human ortholog(s) of this gene implicated in Aicardi-Goutieres syndrome. Orthologous to human RNASEH2C (ribonuclease H2 subunit C). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 106.3), liver E14.5 (RPKM 80.8) and 28 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Rnaseh2c in Genome Data Viewer
    Location:
    19 A; 19 4.34 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (5651901..5652987)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (5601873..5602959)

    Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 31166 Neighboring gene ovo like zinc finger 1 Neighboring gene adaptor-related protein complex 5, beta 1 subunit Neighboring gene STARR-seq mESC enhancer starr_45393 Neighboring gene CapStarr-seq enhancer MGSCv37_chr19:5601776-5601959 Neighboring gene STARR-positive B cell enhancer ABC_E11011 Neighboring gene K(lysine) acetyltransferase 5 Neighboring gene v-rel reticuloendotheliosis viral oncogene homolog A (avian)

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Process Evidence Code Pubs
    involved_in RNA catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in RNA catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in RNA catabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in mismatch repair NAS
    Non-traceable Author Statement
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
     
    part_of ribonuclease H2 complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of ribonuclease H2 complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of ribonuclease H2 complex IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    part_of ribonuclease H2 complex ISO
    Inferred from Sequence Orthology
    more info
     
    part_of ribonuclease H2 complex ISS
    Inferred from Sequence or Structural Similarity
    more info
     

    General protein information

    Preferred Names
    ribonuclease H2 subunit C
    Names
    RNase H2 subunit C
    ribonuclease HI subunit C

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_026616.2NP_080892.1  ribonuclease H2 subunit C

      See identical proteins and their annotated locations for NP_080892.1

      Status: VALIDATED

      Source sequence(s)
      AC126029, AK018776, CD553809
      Consensus CDS
      CCDS29471.1
      UniProtKB/Swiss-Prot
      Q8R1N2, Q9CQ18
      UniProtKB/TrEMBL
      A0A494B9C7
      Related
      ENSMUSP00000025864.5, ENSMUST00000025864.11
      Conserved Domains (1) summary
      pfam08615
      Location:29159
      RNase_H2_suC; Ribonuclease H2 non-catalytic subunit (Ylr154p-like)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000085.7 Reference GRCm39 C57BL/6J

      Range
      5651901..5652987
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)