PCNA proliferating cell nuclear antigen [Homo sapiens (human)] - Gene

Summary

Official Symbol: PCNAprovided by HGNC
Official Full Name: proliferating cell nuclear antigenprovided by HGNC
Primary source: HGNC:HGNC:8729
See related: Ensembl:ENSG00000132646 MIM:176740; AllianceGenome:HGNC:8729
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: ATLD2
Summary: The protein encoded by this gene is found in the nucleus and is a cofactor of DNA polymerase delta. The encoded protein acts as a homotrimer and helps increase the processivity of leading strand synthesis during DNA replication. In response to DNA damage, this protein is ubiquitinated and is involved in the RAD6-dependent DNA repair pathway. Two transcript variants encoding the same protein have been found for this gene. Pseudogenes of this gene have been described on chromosome 4 and on the X chromosome. [provided by RefSeq, Jul 2008]
Expression: Broad expression in bone marrow (RPKM 118.4), lymph node (RPKM 72.7) and 24 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 20p12.3

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	20	NC_000020.11 (5114953..5126622, complement)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	20	NC_060944.1 (5154376..5166040, complement)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	20	NC_000020.10 (5095599..5107268, complement)

Chromosome 20 - NC_000020.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Polyubiquitinated PCNA triggers SLX4-mediated break-induced replication in alternative lengthening of telomeres (ALT) cancer cells.
Title: Polyubiquitinated PCNA triggers SLX4-mediated break-induced replication in alternative lengthening of telomeres (ALT) cancer cells.
Loci on chromosome 20 interact with rs16969968 to influence cigarettes per day in European ancestry individuals.
Title: Loci on chromosome 20 interact with rs16969968 to influence cigarettes per day in European ancestry individuals.
DNAJC24 acts directly with PCNA and promotes malignant progression of LUAD by activating phosphorylation of AKT.
Title: DNAJC24 acts directly with PCNA and promotes malignant progression of LUAD by activating phosphorylation of AKT.
EIF3B stabilizes PCNA by counteracting SYVN1-mediated ubiquitination to serve as a promotor in cholangiocarcinoma.
Title: EIF3B stabilizes PCNA by counteracting SYVN1-mediated ubiquitination to serve as a promotor in cholangiocarcinoma.
Expression of CD44, PCNA and E-cadherin in pterygium tissues.
Title: Expression of CD44, PCNA and E-cadherin in pterygium tissues.
Cryo-EM reveals a nearly complete PCNA loading process and unique features of the human alternative clamp loader CTF18-RFC.
Title: Cryo-EM reveals a nearly complete PCNA loading process and unique features of the human alternative clamp loader CTF18-RFC.
Checkpoint activation by Spd1: a competition-based system relying on tandem disordered PCNA binding motifs.
Title: Checkpoint activation by Spd1: a competition-based system relying on tandem disordered PCNA binding motifs.
Squalene monooxygenase facilitates bladder cancer development in part by regulating PCNA.
Title: Squalene monooxygenase facilitates bladder cancer development in part by regulating PCNA.
G-CSF reshapes the cytosolic PCNA scaffold and modulates glycolysis in neutrophils.
Title: G-CSF reshapes the cytosolic PCNA scaffold and modulates glycolysis in neutrophils.
FANCD2-dependent mitotic DNA synthesis relies on PCNA K164 ubiquitination.
Title: FANCD2-dependent mitotic DNA synthesis relies on PCNA K164 ubiquitination.

Submit: New GeneRIF Correction See all GeneRIFs (406)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Associated conditions

Description	Tests
Ataxia-telangiectasia-like disorder 2 MedGen: C4014676 OMIM: 615919 GeneReviews: Not available	Compare labs

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Protein interactions

Protein	Gene	Interaction	Pubs
Tat	tat	HIV-1 Tat upregulates the expression of proliferating cell nuclear antigen (PCNA) in Jurkat cells	PubMed
	tat	When expressed in astrocytes, neurons, and non-glial 293T cells, HIV-1 Tat interacts with a number of cell cycle-related proteins including cyclin A, cyclin B, cyclin D3, Cdk2, Cdk4, Cdk1/Cdc2, cdc6, p27, p53, p63, hdlg, and PCNA	PubMed

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

G43531 (e-PCR)
- UniSTS:94988

RH78927 (e-PCR)
- UniSTS:42006

RH80338 (e-PCR)
- UniSTS:87854

RH68739 (e-PCR)
- UniSTS:86321

GDB:450240 (e-PCR)
- UniSTS:157304

PMC134733P7 (e-PCR)
- UniSTS:270755

STS-M15796 (e-PCR)
- UniSTS:55287

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables DNA polymerase binding	IPI Inferred from Physical Interaction more info	PubMed
enables DNA polymerase processivity factor activity	IBA Inferred from Biological aspect of Ancestor more info
enables MutLalpha complex binding	IDA Inferred from Direct Assay more info	PubMed
enables chromatin binding	IDA Inferred from Direct Assay more info	PubMed
enables damaged DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables dinucleotide insertion or deletion binding	IDA Inferred from Direct Assay more info	PubMed
enables enzyme binding	IPI Inferred from Physical Interaction more info	PubMed
enables histone acetyltransferase binding	IPI Inferred from Physical Interaction more info	PubMed
enables identical protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables nuclear estrogen receptor binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein-containing complex binding	IDA Inferred from Direct Assay more info	PubMed
enables purine-specific mismatch base pair DNA N-glycosylase activity	IDA Inferred from Direct Assay more info	PubMed
enables receptor tyrosine kinase binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in base-excision repair, gap-filling	IEA Inferred from Electronic Annotation more info
involved_in cellular response to UV	IDA Inferred from Direct Assay more info	PubMed
involved_in cellular response to hydrogen peroxide	IEA Inferred from Electronic Annotation more info
involved_in cellular response to xenobiotic stimulus	IEA Inferred from Electronic Annotation more info
involved_in epithelial cell differentiation	IEP Inferred from Expression Pattern more info	PubMed
involved_in estrous cycle	IEA Inferred from Electronic Annotation more info
involved_in heart development	IEA Inferred from Electronic Annotation more info
involved_in leading strand elongation	IBA Inferred from Biological aspect of Ancestor more info
involved_in liver regeneration	IEA Inferred from Electronic Annotation more info
involved_in mismatch repair	IBA Inferred from Biological aspect of Ancestor more info
involved_in mismatch repair	IDA Inferred from Direct Assay more info	PubMed
involved_in mitotic telomere maintenance via semi-conservative replication	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in negative regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of DNA repair	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of DNA replication	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of DNA-directed DNA polymerase activity	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of deoxyribonuclease activity	IDA Inferred from Direct Assay more info	PubMed
involved_in replication fork processing	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in response to L-glutamate	IEA Inferred from Electronic Annotation more info
involved_in response to cadmium ion	IEA Inferred from Electronic Annotation more info
involved_in response to dexamethasone	IEA Inferred from Electronic Annotation more info
involved_in response to estradiol	IEA Inferred from Electronic Annotation more info
involved_in translesion synthesis	IBA Inferred from Biological aspect of Ancestor more info
involved_in translesion synthesis	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
part_of PCNA complex	IBA Inferred from Biological aspect of Ancestor more info
part_of PCNA complex	IDA Inferred from Direct Assay more info	PubMed
part_of PCNA complex	IPI Inferred from Physical Interaction more info	PubMed
part_of PCNA-p21 complex	IDA Inferred from Direct Assay more info	PubMed
located_in centrosome	IDA Inferred from Direct Assay more info	PubMed
located_in chromatin	IDA Inferred from Direct Assay more info	PubMed
located_in chromosome, telomeric region	HDA more info	PubMed
part_of cyclin-dependent protein kinase holoenzyme complex	IEA Inferred from Electronic Annotation more info
located_in extracellular exosome	HDA more info	PubMed
located_in male germ cell nucleus	IEA Inferred from Electronic Annotation more info
located_in nuclear body	IDA Inferred from Direct Assay more info
located_in nuclear lamina	IEA Inferred from Electronic Annotation more info
located_in nuclear replication fork	IDA Inferred from Direct Assay more info	PubMed
located_in nucleoplasm	IDA Inferred from Direct Assay more info
located_in nucleoplasm	TAS Traceable Author Statement more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in replication fork	IDA Inferred from Direct Assay more info	PubMed
part_of replisome	TAS Traceable Author Statement more info	PubMed

General protein information

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Preferred Names: proliferating cell nuclear antigen

Names: DNA polymerase delta auxiliary protein; cyclin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_047066.1 RefSeqGene

Range

11665..16670

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_002592.2 → NP_002583.1 proliferating cell nuclear antigen

See identical proteins and their annotated locations for NP_002583.1

Status: REVIEWED

Description

Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 encode the same protein.

Source sequence(s)

BC000491, BU626265, CB990423

Consensus CDS

CCDS13087.1

UniProtKB/Swiss-Prot

B2R897, D3DW02, P12004

UniProtKB/TrEMBL

Q6FI35

Related

ENSP00000368458.3, ENST00000379160.3

Conserved Domains (1) summary

TIGR00590
Location:1 → 259

pcna; proliferating cell nuclear antigen (pcna)
NM_182649.2 → NP_872590.1 proliferating cell nuclear antigen

See identical proteins and their annotated locations for NP_872590.1

Status: REVIEWED

Description

Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 encode the same protein.

Source sequence(s)

AK313286, BC000491, BU626265

Consensus CDS

CCDS13087.1

UniProtKB/Swiss-Prot

B2R897, D3DW02, P12004

UniProtKB/TrEMBL

Q6FI35

Related

ENSP00000368438.5, ENST00000379143.10

Conserved Domains (1) summary

TIGR00590
Location:1 → 259

pcna; proliferating cell nuclear antigen (pcna)