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    Dglucy D-glutamate cyclase [ Mus musculus (house mouse) ]

    Gene ID: 217830, updated on 28-Oct-2024

    Summary

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    Official Symbol
    Dglucyprovided by MGI
    Official Full Name
    D-glutamate cyclaseprovided by MGI
    Primary source
    MGI:MGI:2444813
    See related
    Ensembl:ENSMUSG00000021185 AllianceGenome:MGI:2444813
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    9030617O03Rik
    Summary
    Enables D-glutamate cyclase activity. Involved in glutamate metabolic process. Located in mitochondrial matrix. Is expressed in several structures, including adipose tissue; heart; liver; lung; and spleen. Orthologous to human DGLUCY (D-glutamate cyclase). [provided by Alliance of Genome Resources, Oct 2024]
    Expression
    Broad expression in kidney adult (RPKM 29.1), heart adult (RPKM 15.1) and 18 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Dglucy in Genome Data Viewer
    Location:
    12 E; 12 51.1 cM
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (100745316..100838869)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (100779057..100872610)

    Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_33061 Neighboring gene predicted gene 2614 Neighboring gene STARR-seq mESC enhancer starr_33064 Neighboring gene predicted gene, 40558 Neighboring gene predicted gene, 25801 Neighboring gene STARR-seq mESC enhancer starr_33068 Neighboring gene STARR-positive B cell enhancer ABC_E8500 Neighboring gene 60S ribosomal protein L29 pseudogene Neighboring gene G protein-coupled receptor 68 Neighboring gene predicted gene, 36572 Neighboring gene coiled-coil domain containing 88C Neighboring gene RIKEN cDNA A630072L19 gene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. (D)-Glutamate is metabolized in the heart mitochondria. Ariyoshi M, et al. Sci Rep, 2017 Mar 7. PMID 28266638, Free PMC Article
    2. In vivo and in vitro investigations of heterozygous nebulin knock-out mice disclose a mild skeletal muscle phenotype. Gineste C, et al. Neuromuscul Disord, 2013 Apr. PMID 23375831
    3. Construction of a multi-functional cDNA library specific for mouse pancreatic islets and its application to microarray. Nishimura M, et al. DNA Res, 2004 Oct 31. PMID 15747579
    4. USP7 represses lineage differentiation genes in mouse embryonic stem cells by both catalytic and noncatalytic activities. Liu C, et al. Sci Adv, 2023 May 19. PMID 37196079, Free PMC Article
    5. Irisin Mediates Effects on Bone and Fat via αV Integrin Receptors. Kim H, et al. Cell, 2018 Dec 13. PMID 30550785, Free PMC Article

    See all (21) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (2)  1 citation

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Clone Names

    • 9030617O03Rik

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables D-glutamate cyclase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables D-glutamate cyclase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in glutamate metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in glutamate metabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in mitochondrial matrix IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrion HDA PubMed 

    General protein information

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    Preferred Names
    D-glutamate cyclase, mitochondrial
    Names
    UPF0317 protein C14orf159 homolog, mitochondrial
    NP_001347946.1
    NP_001347949.1
    NP_001347952.1
    NP_663423.2
    XP_006515799.1
    XP_006515801.1
    XP_030102529.1
    XP_036013235.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001361017.1 → NP_001347946.1  D-glutamate cyclase, mitochondrial isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AC126262, AC159818, BP765469
      Consensus CDS
      CCDS88389.1
      UniProtKB/TrEMBL
      E9QMK9, Q3U7K4
      Related
      ENSMUSP00000105700.2, ENSMUST00000110073.8
      Conserved Domains (2) summary
      pfam07286
      Location:145 → 285
      DUF1445; Protein of unknown function (DUF1445)
      pfam14336
      Location:329 → 639
      DUF4392; Domain of unknown function (DUF4392)

    2. NM_001361020.1 → NP_001347949.1  D-glutamate cyclase, mitochondrial isoform 2 precursor

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (2) has a shorter N-terminus than isoform 1. Both variants 2 and 3 encode the same isoform (2).
      Source sequence(s)
      AC126262, AC159818
      Consensus CDS
      CCDS26108.1
      UniProtKB/Swiss-Prot
      Q8BH86, Q8BNN0, Q8VC99
      UniProtKB/TrEMBL
      Q3U7K4
      Related
      ENSMUSP00000105696.2, ENSMUST00000110069.8
      Conserved Domains (2) summary
      pfam07286
      Location:115 → 255
      DUF1445; Protein of unknown function (DUF1445)
      pfam14336
      Location:299 → 610
      DUF4392; Domain of unknown function (DUF4392)

    3. NM_001361023.1 → NP_001347952.1  D-glutamate cyclase, mitochondrial isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) has multiple differences, compared to variant 1. These differences result in a distinct 5' UTR and cause translation initiation at a downstream start codon, compared to variant 1. The encoded isoform (3) has a shorter N-terminus than isoform 1.
      Source sequence(s)
      AC126262, AC159818
      Conserved Domains (2) summary
      pfam07286
      Location:2 → 142
      DUF1445; Protein of unknown function (DUF1445)
      pfam14336
      Location:186 → 496
      DUF4392; Domain of unknown function (DUF4392)

    4. NM_145448.5 → NP_663423.2  D-glutamate cyclase, mitochondrial isoform 2 precursor

      See identical proteins and their annotated locations for NP_663423.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (2) has a shorter N-terminus than isoform 1. Both variants 2 and 3 encode the same isoform (2).
      Source sequence(s)
      AC126262, AC159818, AK033551, AK038436
      Consensus CDS
      CCDS26108.1
      UniProtKB/Swiss-Prot
      Q8BH86, Q8BNN0, Q8VC99
      UniProtKB/TrEMBL
      Q3U7K4
      Related
      ENSMUSP00000067830.5, ENSMUST00000069782.11
      Conserved Domains (2) summary
      pfam07286
      Location:115 → 255
      DUF1445; Protein of unknown function (DUF1445)
      pfam14336
      Location:299 → 610
      DUF4392; Domain of unknown function (DUF4392)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000078.7 Reference GRCm39 C57BL/6J

      Range
      100745316..100838869
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006515736.4 → XP_006515799.1  D-glutamate cyclase, mitochondrial isoform X1

      UniProtKB/TrEMBL
      Q3U7K4
      Conserved Domains (2) summary
      pfam07286
      Location:126 → 266
      DUF1445; Protein of unknown function (DUF1445)
      pfam14336
      Location:310 → 621
      DUF4392; Domain of unknown function (DUF4392)

    2. XM_006515738.3 → XP_006515801.1  D-glutamate cyclase, mitochondrial isoform X2

      See identical proteins and their annotated locations for XP_006515801.1

      UniProtKB/Swiss-Prot
      Q8BH86, Q8BNN0, Q8VC99
      UniProtKB/TrEMBL
      Q3U7K4
      Related
      ENSMUSP00000129876.2, ENSMUST00000167322.2
      Conserved Domains (2) summary
      pfam07286
      Location:115 → 255
      DUF1445; Protein of unknown function (DUF1445)
      pfam14336
      Location:299 → 610
      DUF4392; Domain of unknown function (DUF4392)

    3. XM_036157342.1 → XP_036013235.1  D-glutamate cyclase, mitochondrial isoform X3

      Conserved Domains (2) summary
      pfam07286
      Location:2 → 142
      DUF1445; Protein of unknown function (DUF1445)
      pfam14336
      Location:186 → 496
      DUF4392; Domain of unknown function (DUF4392)

    4. XM_030246669.2 → XP_030102529.1  D-glutamate cyclase, mitochondrial isoform X2

      UniProtKB/Swiss-Prot
      Q8BH86, Q8BNN0, Q8VC99
      UniProtKB/TrEMBL
      Q3U7K4
      Conserved Domains (2) summary
      pfam07286
      Location:115 → 255
      DUF1445; Protein of unknown function (DUF1445)
      pfam14336
      Location:299 → 610
      DUF4392; Domain of unknown function (DUF4392)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8BH86.1 GenPept UniProtKB/Swiss-Prot:Q8BH86

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