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    Cpn2 carboxypeptidase N, polypeptide 2 [ Mus musculus (house mouse) ]

    Gene ID: 71756, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Cpn2provided by MGI
    Official Full Name
    carboxypeptidase N, polypeptide 2provided by MGI
    Primary source
    MGI:MGI:1919006
    See related
    Ensembl:ENSMUSG00000023176 AllianceGenome:MGI:1919006
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    1300018K11Rik
    Summary
    Predicted to be involved in inorganic cation transmembrane transport; metal ion transport; and monoatomic cation transmembrane transport. Located in collagen-containing extracellular matrix. Orthologous to human CPN2 (carboxypeptidase N subunit 2). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in liver adult (RPKM 111.2) and liver E18 (RPKM 15.0) See more
    Orthologs
    human all
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    Genomic context

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    See Cpn2 in Genome Data Viewer
    Location:
    16 B2; 16 21.22 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (30075196..30086350, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (30256378..30267532, complement)

    Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 26562 Neighboring gene RIKEN cDNA 1700025H01 gene Neighboring gene STARR-seq mESC enhancer starr_40571 Neighboring gene STARR-seq mESC enhancer starr_40572 Neighboring gene STARR-positive B cell enhancer ABC_E5535 Neighboring gene predicted gene, 33330 Neighboring gene STARR-seq mESC enhancer starr_40574 Neighboring gene leucine rich repeat containing 15 Neighboring gene glycoprotein 5 platelet

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Enhanced analysis of the mouse plasma proteome using cysteine-containing tryptic glycopeptides. Bernhard OK, et al. J Proteome Res, 2007 Mar. PMID 17330941
    2. Proteome-wide characterization of N-glycosylation events by diagonal chromatography. Ghesquière B, et al. J Proteome Res, 2006 Sep. PMID 16944957
    3. The matrisome: in silico definition and in vivo characterization by proteomics of normal and tumor extracellular matrices. Naba A, et al. Mol Cell Proteomics, 2012 Apr. PMID 22159717, Free PMC Article
    4. BraInMap Elucidates the Macromolecular Connectivity Landscape of Mammalian Brain. Pourhaghighi R, et al. Cell Syst, 2020 Apr 22. PMID 32325033, Free PMC Article
    5. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (1) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in inorganic cation transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in metal ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in monoatomic cation transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in collagen-containing extracellular matrix HDA PubMed 
    is_active_in extracellular matrix IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    carboxypeptidase N subunit 2
    Names
    carboxypeptidase N 83 kDa chain
    carboxypeptidase N large subunit
    carboxypeptidase N regulatory subunit
    carboxypeptidase N, polypeptide 2 homolog
    NP_082180.2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_027904.3 → NP_082180.2  carboxypeptidase N subunit 2 precursor

      See identical proteins and their annotated locations for NP_082180.2

      Status: VALIDATED

      Source sequence(s)
      AC163355, AK005049
      Consensus CDS
      CCDS49819.1
      UniProtKB/Swiss-Prot
      B2RR89, Q8R113, Q9DBB9
      Related
      ENSMUSP00000069318.8, ENSMUST00000064856.9
      Conserved Domains (5) summary
      smart00013
      Location:21 → 52
      LRRNT; Leucine rich repeat N-terminal domain
      smart00082
      Location:395 → 436
      LRRCT; Leucine rich repeat C-terminal domain
      cd00116
      Location:149 → 374
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      sd00033
      Location:123 → 146
      LRR_RI; leucine-rich repeat [structural motif]
      pfam13855
      Location:313 → 373
      LRR_8; Leucine rich repeat

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000082.7 Reference GRCm39 C57BL/6J

      Range
      30075196..30086350 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9DBB9.2 GenPept UniProtKB/Swiss-Prot:Q9DBB9

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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