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    Mei4 meiotic double-stranded break formation protein 4 [ Mus musculus (house mouse) ]

    Gene ID: 75033, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Mei4provided by MGI
    Official Full Name
    meiotic double-stranded break formation protein 4provided by MGI
    Primary source
    MGI:MGI:1922283
    See related
    Ensembl:ENSMUSG00000043289 AllianceGenome:MGI:1922283
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    4930486G11Rik
    Summary
    Involved in meiotic DNA double-strand break formation. Acts upstream of or within homologous chromosome pairing at meiosis; oogenesis; and spermatogenesis. Located in lateral element. Is expressed in spermatocyte. Orthologous to human MEI4 (meiotic double-stranded break formation protein 4). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Low expression observed in reference dataset See more
    Orthologs
    human all
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    Genomic context

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    See Mei4 in Genome Data Viewer
    Location:
    9 E1; 9 44.72 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (81745723..82088060)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (81863670..82206007)

    Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA D430036J16 gene Neighboring gene STARR-seq mESC enhancer starr_24767 Neighboring gene STARR-seq mESC enhancer starr_24768 Neighboring gene 5-hydroxytryptamine (serotonin) receptor 1B Neighboring gene predicted gene, 53506 Neighboring gene SET nuclear oncogene pseudogene Neighboring gene STARR-seq mESC enhancer starr_24769 Neighboring gene STARR-seq mESC enhancer starr_24770 Neighboring gene STARR-seq mESC enhancer starr_24771 Neighboring gene STARR-seq mESC enhancer starr_24772 Neighboring gene STARR-seq mESC enhancer starr_24773 Neighboring gene STARR-seq mESC enhancer starr_24774 Neighboring gene STARR-seq mESC enhancer starr_24775 Neighboring gene tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide pseudogene Neighboring gene RIKEN cDNA 1700063H06 gene Neighboring gene predicted gene, 23748 Neighboring gene predicted gene, 35548

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Bi-allelic missense variants in MEI4 cause preimplantation embryonic arrest and female infertility. Pan Z, et al. Hum Genet, 2024 Oct. PMID 38252283
    2. Characterization of the REC114-MEI4-IHO1 complex regulating meiotic DNA double-strand break formation. Laroussi H, et al. EMBO J, 2023 Aug 15. PMID 37431931, Free PMC Article
    3. Mouse ANKRD31 Regulates Spatiotemporal Patterning of Meiotic Recombination Initiation and Ensures Recombination between X and Y Sex Chromosomes. Papanikos F, et al. Mol Cell, 2019 Jun 6. PMID 31000436
    4. Ensuring meiotic DNA break formation in the mouse pseudoautosomal region. Acquaviva L, et al. Nature, 2020 Jun. PMID 32461690, Free PMC Article
    5. Principles of chromosome organization for meiotic recombination. Biot M, et al. Mol Cell, 2024 May 16. PMID 38657614

    See all (24) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Bi-allelic missense variants in MEI4 cause preimplantation embryonic arrest and female infertility.
      Title: Bi-allelic missense variants in MEI4 cause preimplantation embryonic arrest and female infertility.
    2. Characterization of the REC114-MEI4-IHO1 complex regulating meiotic DNA double-strand break formation.
      Title: Characterization of the REC114-MEI4-IHO1 complex regulating meiotic DNA double-strand break formation.
    3. the association of MEI4 to chromosome axes is required for DNA double-strand break formation.
      Title: MEI4 – a central player in the regulation of meiotic DNA double-strand break formation in the mouse.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (1)  1 citation

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in DNA recombination IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in homologous chromosome pairing at meiosis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within homologous chromosome pairing at meiosis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in meiotic DNA double-strand break formation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in meiotic DNA double-strand break formation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in oogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within oogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in spermatogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within spermatogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in chromosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in lateral element IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in lateral element IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    meiosis-specific protein MEI4
    Names
    UPF0623 protein
    meiosis-specific, MEI4 homolog

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001357477.1 → NP_001344406.1  meiosis-specific protein MEI4 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 3' UTR and coding sequence compared to variant 1. The resulting isoform (2) has a shorter and distinct C-terminus compared to isoform 1.
      Source sequence(s)
      AC140070, AC163294, AK082395
      Consensus CDS
      CCDS90635.1
      Related
      ENSMUSP00000140647.2, ENSMUST00000189832.7
      Conserved Domains (1) summary
      pfam13971
      Location:2 → 300
      Mei4; Meiosis-specific protein Mei4

    2. NM_001357479.1 → NP_001344408.1  meiosis-specific protein MEI4 isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) lacks an alternate exon compared to variant 1. The resulting isoform (3) is shorter at the N-terminus compared to isoform 1.
      Source sequence(s)
      AC122931, AC132430, AC163294
      Consensus CDS
      CCDS90636.1
      UniProtKB/TrEMBL
      A0A087WP18, Q3TM14
      Related
      ENSMUSP00000139589.2, ENSMUST00000189391.2
      Conserved Domains (1) summary
      pfam13971
      Location:4 → 278
      Mei4; Meiosis-specific protein Mei4

    3. NM_175213.4 → NP_780422.1  meiosis-specific protein MEI4 isoform 1

      See identical proteins and their annotated locations for NP_780422.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AC122931, AC163294, AK043929
      Consensus CDS
      CCDS23371.1
      UniProtKB/Swiss-Prot
      Q4V9Z7, Q8BRM6, Q8C4E8
      UniProtKB/TrEMBL
      Q3TM14
      Related
      ENSMUSP00000061341.3, ENSMUST00000057067.10
      Conserved Domains (1) summary
      pfam13971
      Location:1 → 377
      Mei4; Meiosis-specific protein Mei4

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000075.7 Reference GRCm39 C57BL/6J

      Range
      81745723..82088060
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8BRM6.1 GenPept UniProtKB/Swiss-Prot:Q8BRM6

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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